３．１１と知識の伝承

技術者の倫理として、人工物を媒介とした倫理を取り上げる。この枠組みの下で他の伝統的専門家と技術者を対比し、ものづくりをする人のリスクコミュニケーションを考える。そして、技術導入の一種である完成晶納入契約(ターンキー契約)のあり方や、9.11をきっかけとしたアメリカの対策義務(B.5.b)の日本での受け入れについて取り上げる。特集／福島原発事故で工学倫理を考え

Epoxidation of diastereomeric 4-(α-hydroxyethyl)-3-carenes

Epoxldation of diastereomeric 4-(hydroxyethyl)- and 4-(acetoxyethyl)-3-carenes stereospecifically gives trans isomers of the corresponding epoxides. © 1979 Plenum Publishing Corporation

FEATURES OF IMMUNOCOMPETENT CELLS IN THE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AT PRIMARY DIAGNOSIS

Some basic parameters of immune profile have been investigated in 140 patients with chronic lymphocytic leukemia (CLL). There was shown that the cohort of CLL patients is heterogeneous for their immune profile as early as at primary diagnosis stage, showing sufficient differences in the numbers of immunocompetent cells in peripheral blood. In most cases, the interpretation of appropriate quantitative characteristics is quite difficult, if based on the conventional criteria. The numbers of activated T-lymphocytes and NK-cells were proven to be the most informative parameters of cellular immunity in this cohort. Progression of leukemic events shows a close association with only a single parameter under study, i.e., CD4+/CD8+ cell ratio

THE RESULTS OF THE STUDY OF VARIETIES OF ALFALFA IN THE CENTRAL-CHERNOZEM ZONE

Three-year study of one hundred world collection of alfalfa was conducted in Central Black-Earth zone of Russia. The varieties of Medicago × varia ‘Zheltogibridnaya 99’, ‘Flora 2’, ‘Karlygash’ and ‘№ 152’ (hybrid ‘Severnaya hybridnaya’ בAugune II’) were recommended for breeding programs. The most variable were character of seed production, productivity of green mass and hay yield productivity; character of foliage and the intensity of regrowth of plants on the 20-th day after spring regrowth had medium variability. The height before the first mowing and height in the phase of full flowering had low variability. There was a significant correlation between the yield of green mass and hay, the yield of green mass and intensity of regrowth and a weak negative correlation between the yield of green mass and seed yield

Gastric Microbiota and Morphological Changes of the Gastroduodenal Tract Associated with Helicobacter Pylori Infection

© 2016, Springer Science+Business Media New York.Investigation of the microbiota at morphological changes of a gastrointestinal tract. One hundred four patients were examined by cytologic, bacteriological methods, and mass-spectrometry techniques. Studying of the microbial association of stomach has demonstrated the mixed microflora presented by Helicobacter pylori, cocci, fungi Candida, rods, and protozoa. Bacteria of the following species were found: Actinomyces, Arthrobacter, Bacillus, Corynebacterium, Lactobacillus, Neisseria, Pseudomonas, Rothia, Staphylococcus, Streptococcus, and Streptomyces. The microbial flora of esophageal samples was less various (opportunistic bacteria Neisseria, Gemella, and Rothia mucilaginosa were revealed). In group of Helicobacter-positive patients, bacteria were found in fungi Candida, Colletotrichum, and bacterias Thauera and Mycoplasma, while in H.pylori-negative patients, samples have more different species. Intensity of morphological changes (the atrophy, the intestinal metaplasia, and the dysplasia) correlated with a frequency of detection of H. pylori and eukaryotic microbiota (fungi Candida and protozoa)

4.各部門の活動内容 理学療法科

© 2016, Springer Science+Business Media New York.Investigation of the microbiota at morphological changes of a gastrointestinal tract. One hundred four patients were examined by cytologic, bacteriological methods, and mass-spectrometry techniques. Studying of the microbial association of stomach has demonstrated the mixed microflora presented by Helicobacter pylori, cocci, fungi Candida, rods, and protozoa. Bacteria of the following species were found: Actinomyces, Arthrobacter, Bacillus, Corynebacterium, Lactobacillus, Neisseria, Pseudomonas, Rothia, Staphylococcus, Streptococcus, and Streptomyces. The microbial flora of esophageal samples was less various (opportunistic bacteria Neisseria, Gemella, and Rothia mucilaginosa were revealed). In group of Helicobacter-positive patients, bacteria were found in fungi Candida, Colletotrichum, and bacterias Thauera and Mycoplasma, while in H.pylori-negative patients, samples have more different species. Intensity of morphological changes (the atrophy, the intestinal metaplasia, and the dysplasia) correlated with a frequency of detection of H. pylori and eukaryotic microbiota (fungi Candida and protozoa)

Monitoring of respiratory viral infections in Moscow during 2011–2022

Introduction. Respiratory viruses (RV) circulate throughout the world and in all seasons of the year. Long-term monitoring of the distribution of respiratory pathogens is necessary to analyze the relevance of diagnostic systems to current viral isolates, to assess the risks of infection and the need for vaccine development and use, as well as to investigate the interdependence of RV reproduction in mixed infections. Objective — to study the causative agents of acute respiratory viral infections (ARVI) in Moscow during 2011–2022 by reverse transcription with subsequent polymerase chain reaction with fluorescent hydrolysis probes detection in real-time (RT2-PCR). Materials and Methods. Nasopharyngeal swabs from 3908 patients with acute respiratory infections were examined by the RT2-PCR. Results. Monitoring of RV spread in Moscow showed cyclical changes in frequencies with three dominant species: influenza A virus (up to 31.3%), respiratory syncytial virus (up to 24.8%) and human rhinoviruses (up to 21.3%) in 2011–2020. The increase in the portion of unidentified clinical specimens from 1.2 to 28.5% in 2022 indicated incomplete accordance of diagnostic systems to modern RV isolates or the emergence of new species or strains of pathogens. Unidirectional changes in dynamics were registered for 5 out of 9 studied RVs with correlation coefficients of 0.43–0.79. High frequencies of mixed acute respiratory viral infections (up to 33.4%) along with unidentified samples do not allow us to accurately assess the risks of infection with various RV in Moscow, but prove the necessity of preventing infectious diseases with the most common RV. Conclusion. Analysis of the dynamics of RV frequencies in Moscow showed the preservation of the dominant species: influenza A virus, respiratory syncytial virus and human rhinoviruses. During the period of vaccination against COVID-19, the proportion of seasonal coronaviruses increased

Oxidation of carene by thallium(III) acetate

2-p-Tolylpropanol-2, p-menth-1,8-dien-3-ol, p-menth-1-en-3α, 8-diol, p-menth-1-en-3β, 8-diol, p-menth-1-en-3-on-8-ol, p-menth-1,8-dien-5,6-diol, and 2,3-dihydroxy-1,8-cineole are formed during the oxidation of 2-carene by thallium (III) acetate. © 1984 Plenum Publishing Corporation

Frequency of Interferon-Resistance Conferring Substitutions in Amino Acid Positions 70 and 91 of Core Protein of the Russian HCV 1b Isolates Analyzed in the T-Cell Epitopic Context

Funding Information: This study was supported by the grant of the Russian Science Foundation (Project ID 15-15-30039). Mobility and training of the researchers was supported by the grants of the Swedish Institute (TP 09272/2013 and PI 19806/2016). Publisher Copyright: © 2018 V. S. Kichatova et al.Amino acid substitutions R70Q/H and L91M in HCV subtype 1b core protein can affect the response to interferon and are associated with the development of hepatocellular carcinoma. We found that the rate of R70Q/H in HCV 1b from Russia was 31.2%, similar to that in HCV strains from Asia (34.0%), higher than that in the European (18.0%, p=0.0010), but lower than that in the US HCV 1b strains (62.8%, p<0.0001). Substitution L91M was found in 80.4% of the Russian HCV 1b isolates, higher than in Asian isolates (43.8%, p<0.0001). Thus, a significant proportion of Russian HCV 1b isolates carry the unfavorable R70Q/H and/or L91M substitution. In silico analysis of the epitopic structure of the regions of substitutions revealed that both harbor clusters of T-cell epitopes. Peptides encompassing these regions were predicted to bind to a panel of HLA class I molecules, with substitutions impairing peptide recognition by HLA I molecules of the alleles prevalent in Russia. This indicates that HCV 1b with R70Q/H and L91M substitutions may have evolved as the immune escape variants. Impairment of T-cell recognition may play a part in the negative effect of these substitutions on the response to IFN treatment.Peer reviewe

The role of active herpesvirus infection in the formation of atopic dermatitis and psoriasis

The results of previous studies suggest the involvement of herpes viruses in the development of atopic dermatitis and psoriasis, but there is no convincing evidence. Aim of the study was to evaluate the role of active herpesvirus infection in exacerbation of atopic dermatitis and psoriasis. Material and methods. The analysis of the incidence of infectious mononucleosis, genital herpes, cytomegalovirus infection, skin and subcutaneous tissue diseases, atopic dermatitis, psoriasis in Russia in 2000–2020 was carried out. 92 blood donors and 97 patients with skin and subcutaneous tissue diseases (44 with atopic dermatitis and 53 with psoriasis) were examined for the presence of immunoglobulins M and G to herpes simplex viruses (HSV1,2), Epstein-Barr (EBV), cytomegalovirus (CMV), human herpes type 6 (HНV6). Results and discussion. A significant strong direct correlation was revealed between the incidence of genital herpes and diseases of the skin and subcutaneous tissue (p = 0.85), atopic dermatitis (p = 0.85); infectious mononucleosis and psoriasis (p = 0.85). The frequency of detection of IgM to HSV1,2, in total, IgG EA and IgM VCA EBV in the group of patients is significantly higher than in donors (p &lt; 0.05). In patients with atopic dermatitis, IgM to HSV1 were detected significantly more often than in individuals with psoriasis, and markers of active EBV infection were significantly less common. The presence of IgM HSV-1 statistically significantly increases the incidence of atopic dermatitis (relative risk (RR) = 2.3, 95 % confidence interval (95 % CI) 1.6–3.3)), IgM VCA and IgG EA EBV – the incidence of psoriasis (RR = 2.3, 95 % CI 1.5–3.3). Conclusions. It has been shown for the first time that active HSV1,2 infection is a trigger factor for the development of atopic dermatitis, EBV infection is psoriasis