10 research outputs found
Plasmid-linked nif and "nod" genes in fast-growing rhizobia that nodulate Glycine max, Psophocarpus tetragonolobus, and Vigna unguiculata
No full textSynthesis of an opine-like compound, a rhizopine, in alfalfa nodules is symbiotically regulated.
No full textGenes for the catabolism and synthesis of an opine-like compound in Rhizobium meliloti are closely linked and on the Sym plasmid
No full textPractical suggestions for credible empirical legal research
No full textA guide with specific steps law researchers, journals, and schools can take to improve empirical legal researc
Erratum: Corrigendum: An environmental bacterial taxon with a large and distinct metabolic repertoire
No full textWilson MC, Mori T, Rückert C, et al. Erratum: Corrigendum: An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature. 2014;507(7491):262-262
Heterotrimeric G Protein Subunit G\u3b1q Is a Master Switch for G\u3b2\u3b3-Mediated Calcium Mobilization by Gi-Coupled GPCRs
No full textCalcium mobilization by Gi-coupled GPCRs has been perceived as a stand-alone signaling mechanism for almost 30 years. Here, Pfeil et al. report the unexpected discovery that this quintessential biological process does not occur without, and totally depends on, the heterotrimeric G protein subunit G\u3b1q in the living cell context
An environmental bacterial taxon with a large and distinct metabolic repertoire
Get PDFWilson MC, Mori T, Rückert C, et al. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature. 2014;506(7486):58-62.: Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such 'talented' producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic diversity. The uncultured majority is generally perceived as a large, untapped resource of new drug candidates, but so far it is unknown whether taxa containing talented bacteria indeed exist. Here we report the single-cell- and metagenomics-based discovery of such producers. Two phylotypes of the candidate genus 'Entotheonella' with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clusters co-inhabit the chemically and microbially rich marine sponge Theonella swinhoei. Almost all bioactive polyketides and peptides known from this animal were attributed to a single phylotype. 'Entotheonella' spp. are widely distributed in sponges and belong to an environmental taxon proposed here as candidate phylum 'Tectomicrobia'. The pronounced bioactivities and chemical uniqueness of 'Entotheonella' compounds provide significant opportunities for ecological studies and drug discovery
