Experience with a vectorized general circulation weather model on Star-100

A version of an atmospheric general circulation model was vectorized to run on a CDC STAR 100. The numerical model was coded and run in two different vector languages, CDC and LRLTRAN. A factor of 10 speed improvement over an IBM 360/95 was realized. Efficient use of the STAR machine required some redesigning of algorithms and logic. This precludes the application of vectorizing compilers on the original scalar code to achieve the same results. Vector languages permit a more natural and efficient formulation for such numerical codes

Blending process assessment and employees competencies assessment in very small entities

The ISO/IEC 29110 series aims to provide Very Small Entities (VSEs) with a set of standards based on subsets of existing standards. Process capability determination does not seem suitable for a VSE in terms of return on investment. Our approach proposes to move the viewpoint away from process and to the human resources. We propose a blended assessment model using the ISO/IEC 15504 for the level 1, but based on competency assessment for higher capability levels

Using CLIPS to Detect Network Intrusions

We describe how to build a network intrusion detection sensor by slightly modifying NASA's CLIPS source code introducing some new features. An overview of the system is presented emphasizing the strategies used to inter-operate between the packet capture engine written in C and CLIPS. Some extensions were developed in order to manipulate timestamps, multiple string pattern matching and certainty factors. Several Snort functions and plugins were adapted and used for packet decoding and preprocessing. A rule translator was also built to reuse most of the Snort's attack signatures. Despite some performance drawbacks, results prove that CLIPS can be used for real-time network intrusion detection under certain conditions. Several attack signatures using CLIPS rules are showed in the appendix. By mixing CLIPS with Snort features, it was possible to introduce flexibility and expressiveness to network intrusion detection

gViz, a novel tool for the visualization of co-expression networks

<p>Abstract</p> <p>Background</p> <p>The quantity of microarray data available on the Internet has grown dramatically over the past years and now represents millions of Euros worth of underused information. One way to use this data is through co-expression analysis. To avoid a certain amount of bias, such data must often be analyzed at the genome scale, for example by network representation. The identification of co-expression networks is an important means to unravel gene to gene interactions and the underlying functional relationship between them. However, it is very difficult to explore and analyze a network of such dimensions. Several programs (Cytoscape, yEd) have already been developed for network analysis; however, to our knowledge, there are no available GraphML compatible programs.</p> <p>Findings</p> <p>We designed and developed gViz, a GraphML network visualization and exploration tool. gViz is built on clustering coefficient-based algorithms and is a novel tool to visualize and manipulate networks of co-expression interactions among a selection of probesets (each representing a single gene or transcript), based on a set of microarray co-expression data stored as an adjacency matrix.</p> <p>Conclusions</p> <p>We present here gViz, a software tool designed to visualize and explore large GraphML networks, combining network theory, biological annotation data, microarray data analysis and advanced graphical features.</p

Social context and sex moderate the association between type D personality and cardiovascular reactivity

peer-reviewedType D personality has been consistently associated with adverse cardiovascular health with atypical cardiovascular reactions to psychological stress one plausible underlying mechanism. However, whether this varies by sex and social context has received little attention. This study examined the interaction between Type D personality, sex and social context on cardiovascular reactivity to acute stress. A sample of 76 healthy undergraduate students (47 female) completed the DS14 Type D measure, before undergoing a traditional cardiovascular reactivity protocol. The social context of the laboratory environment was manipulated to create a social and non-social context using a between-subjects design. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were monitored throughout. No associations were evident for blood pressure. However, a significant personality × sex × social context interaction on HR reactivity was found; here Type D was associated with a higher HR response to the social task amongst males but not females, while Type D females typically exhibited blunted reactions. While these atypical reactions indicate a possible psychophysiological pathway leading to adverse cardiovascular events amongst Type Ds, it appears that Type D males are particularly vulnerable to socially based stressors, exhibiting exaggerated cardiovascular reactions.peer-reviewe

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers

SOFTWARE PROCESS IMPROVEMENT: AWARENESS, USE, AND BENEFITS IN CANADIAN SOFTWARE DEVELOPMENT FIRMS

Since 1982, the software development community has been concerned with the delivery of quality systems. Software process improvement (SPI) is an initiative to avoid the delivery of low quality systems. However, the awareness and adoption of SPI is low. Thus, this study examines the rate of awareness, use, and benefits of SPI initiatives in Canadian software development firms. Using SPSS as the analytical tool, this study found that 59% of Canadian software development firms are aware of SPI programs and 43% of employees use a form of SPI programs to develop software products. Although the sample size is small and the results cannot be generalized, the sample firms that use SPI programs reported an improvement in software product quality as the greatest benefit. These findings confirm the importance of SPI programs as a means of producing higher-quality software products, which can increase the likelihood of software companies winning global contracts