Perforated mixed carcinoid-adenocarcinoma in transverse colon and at gastroenterostomy site: case report

Goblet cell carcinoid of the large intestine is a rare neoplasm, usually located in ascending colon and rectum. A 60-year-old male patient underwent surgery after the diagnosis of acute abdomen. Exploratory laparotomy revealed perforation with a diameter of 1 cm at the site of the previously performed gastroenterostomy and dilatation of the right colic flexure, secondary to a solid obstructive mass located in the mid-portion of transverse colon. Histopathological investigation of the biopsies, taken from the gastroenterostomy site and the tumor, revealed mixed carcinoid-adenocarcinoma with carcinoid component, predominantly composed of goblet cells. Three cycles of FOLFOX-4 protocol was administered. Following respiratory distress secondary to pulmonary metastasis, the patient's condition deteriorated and subsequently died in the fourth postoperative month. Our aim with this paper is to point out that more cases should be reported for more effective diagnosis, histopathological study, clinical investigation, treatment and prognosis of this specific neoplasm

Investigation of P53 Gene Codon72 Polymorphism in Colon Cancer

22nd Biennial Congress of the European-Association-for-Cancer-Research -- JUL 07-10, 2012 -- Barcelona, SPAINWOS: 000313036501038…European Assoc Canc Re

The Relationship Between Colon Cancer and Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism

22nd Biennial Congress of the European-Association-for-Cancer-Research -- JUL 07-10, 2012 -- Barcelona, SPAINWOS: 000313036501039…European Assoc Canc Re

Plasminogen Activator Inhibitor Type-1 (PAI-1) Gene 4G/5G Polymorphism and Genetic Tendency to Colon Cancer

22nd Biennial Congress of the European-Association-for-Cancer-Research -- JUL 07-10, 2012 -- Barcelona, SPAINWOS: 000313036501043…European Assoc Canc Re

Effect of leptin on renal ischemia-reperfusion damage in rats

Tumor necrosis factor-alfa (TNF-a) has been established as an important mediator in of renal ischemia-reperfusion (I/R) injury. Leptin, a product of the ob gene, has been known to exhibit cytoprotective effects on renal tissue, but its effect on renal tissue TNF-a level after renal I/R injury in rats remains unknown. The purpose of the study was to evaluate the effects of leptin on renal tissue TNF-a, malondialdehyde (MDA), protein carbonyls (PCs) and total sulfydryl group (SH) levels, and plasma nitrite levels after renal I/R injury in rats. The animals were divided into three groups: control, I/R and I/R+leptin. Rats were subjected to renal ischemia by clamping the left pedicle for 45 min, and then reperfused for 1 h. The I/R+leptin group was pretreated intraperitoneally with leptin (10 mg/kg) 30 min before the induction of ischemia. Our results indicate that MDA, TNF-a levels, and PCs were significantly higher in the I/R group than those in the control group (p<0.05). The administration of leptin decreased these parameters (p<0.05) significantly. The SH level was observed to significantly decrease after I/R injury when compared to the control group (p<0.05). Leptin treatment significantly increased tissue SH and plasma nitrite levels when compared to the I/R group (p<0.05). Plasma nitrite levels did not change significantly in I/R when compared to the control. These results suggest that leptin could exert a protective effect on I/R induced renal damage by through decreasing TNF-a levels and increasing nitrite levelEl factor de necrosis tumoral alfa (TNF-a) es un mediador importante en la lesión renal tras isquemia y reperfusión (I/R). Dado que se ha observado que la leptina presenta un efecto citoprotector sobre el tejido renal, se estudia en este trabajo el efecto de la hormona sobre el contenido en el tejido renal de TNF-a, malondialdehido (MDA), niveles de grupos carbonilo protéicos (PC) y de los grupos de sulfhidrilo total (SH), y el nivel plasmático de nitrito tras lesión renal por isquemia/reperfusión en rata. Los animales se repartían en tres grupos de 8 ejemplares: control, I/R, e I/R+leptina. Las ratas se sometían a una isquemia renal durante 45 minutos con ulterior reperfusión de una hora. A los del grupo I/R+leptina se les había administrado por vía intraperitoneal leptina (10 mg/kg) 30 minutos antes de la inducción de la isquemia. Los resultados indican que el contenido en MDA, TNF-a y PC está significativamente elevado en el grupo I/R respecto del grupo de control (p<0,05), mientras que el de SH se reduce tras la lesión I/R y el nivel de nitrito en el plasma no varía. El tratamiento con leptina anula los incrementos de los niveles renales de TNF-a, MDA y PC y de la disminución de grupos SH en tejido renal y de nitritos plasmáticos por isquemia/reperfusión renal. Estos resultados sugieren que la leptina ejerce un efecto protector sobre la lesión renal inducida por isquemia y reperfusión por la disminución de TNF-a y el aumento plasmático de nitrit

Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line

OBJECTIVE: The aim of this study was to investigate the effects of a novel anti-cancer drug, ceranib-2, which targets the acid ceramidase, in human colon cancer cell line

The effect of leptin and resveratrol on JAK/STAT pathways and Sirt-1 gene expression in the renal tissue of ischemia//reperfusion induced rats

OBJECTIVE: Our study aimed to investigate the possible modifying effects of leptin and combined use of resveratrol on rat renal I/R injury and their relationship on signal pathways and apoptosis-related mechanisms