Fistule carotido-caverneuse post-traumatique

Introduction : La fistule carotido-caverneuse (FCC) est une complication rare, mais grave des traumatismes craniofaciaux pouvant engager le pronostic fonctionnel oculaire et le pronostic vital. elle réalise une communication anormale entre le système artériel carotidien et le sinus caverneux.Buts : Rapporter un cas de FCC directe post-traumatique et étudier les aspects cliniques, diagnostiques et thérapeutiques de cette pathologie.Observation : Nous rapportons un cas de FCC apparue dans les suites d’un traumatisme craniofacial et survenue chez un homme de 25 ans ayant été victime d’un accident de la voie publique. Le diagnostic a été suspecté devant l’apparition, au 19ème jour d’hospitalisation, d’une exophtalmie unilatérale gauche pulsatile associée à un important chémosis et à une pupille aréflectique. Une artériographie cérébrale pratiquée 9 jours après la constatation de l’exophtalmie a objectivé une large FCC gauche. Une embolisation au moyen de deux ballonnets intravasculaires largables et de l’injection de colle biologique a été réalisée au même temps sans incidents permettant d’obtenir l’occlusion complète de la fistule. L’évolution a été marquée par la régression de l’exophtalmie et du chémosis et par l’amélioration partielle de l’acuité visuelle.Conclusion : Le traitement des FCC est urgent et est principalement basé sur la neuroradiologie interventionnelle. en effet, l’angiographie cérébrale constitue l’examen clé et possède un double intérêt diagnostique et thérapeutique.Mots clés : fistule carotido-caverneuse, traumatisme craniofacial, artériographie cérébrale, embolisation

Equilibria-based Probabilistic Model Checking for Concurrent Stochastic Games

Probabilistic model checking for stochastic games enables formal verification of systems that comprise competing or collaborating entities operating in a stochastic environment. Despite good progress in the area, existing approaches focus on zero-sum goals and cannot reason about scenarios where entities are endowed with different objectives. In this paper, we propose probabilistic model checking techniques for concurrent stochastic games based on Nash equilibria. We extend the temporal logic rPATL (probabilistic alternating-time temporal logic with rewards) to allow reasoning about players with distinct quantitative goals, which capture either the probability of an event occurring or a reward measure. We present algorithms to synthesise strategies that are subgame perfect social welfare optimal Nash equilibria, i.e., where there is no incentive for any players to unilaterally change their strategy in any state of the game, whilst the combined probabilities or rewards are maximised. We implement our techniques in the PRISM-games tool and apply them to several case studies, including network protocols and robot navigation, showing the benefits compared to existing approaches

Evaluating the Effectiveness of Coagulation–Flocculation Treatment Using Aluminum Sulfate on a Polluted Surface Water Source: A Year-Long Study

\ua9 2024 by the authors.Safeguarding drinking water is a major public health and environmental concern because it is essential to human life but may contain pollutants that can cause illness or harm the environment. Therefore, continuous research is necessary to improve water treatment methods and guarantee its quality. As part of this study, the effectiveness of coagulation–flocculation treatment using aluminum sulfate (Al2(SO4)3) was evaluated on a very polluted site. Samplings were taken almost every day for a month from the polluted site, and the samples were characterized by several physicochemical properties, such as hydrogen potential (pH), electrical conductivity, turbidity, organic matter, ammonium (NH+4), phosphate (PO43−), nitrate (NO3−), nitrite (NO2−), calcium (Ca2+), magnesium (Mg2+), total hardness (TH), chloride (Cl−), bicarbonate (HCO3−), sulfate (SO42−), iron (Fe3+), manganese (Mn2+), aluminum (Al3+), potassium (K+), sodium (Na+), complete alkalimetric titration (TAC), and dry residue (DR). Then, these samples were treated with Al2(SO4)3 using the jar test method, which is a common method to determine the optimal amount of coagulant to add to the water based on its physicochemical characteristics. A mathematical model had been previously created using the support vector machine method to predict the dose of coagulant according to the parameters of temperature, pH, TAC, conductivity, and turbidity. This Al2(SO4)3 treatment step was repeated at the end of each month for a year, and a second characterization of the physicochemical parameters was carried out in order to compare them with those of the raw water. The results showed a very effective elimination of the various pollutions, with a very high rate, thus demonstrating the effectiveness of the Al2(SO4)3. The physicochemical parameters measured after the treatment showed a significant reduction in the majority of the physicochemical parameters. These results demonstrated that the coagulation–flocculation treatment with Al2(SO4)3 was very effective in eliminating the various pollutions present in the raw water. They also stress the importance of continued research in the field of water treatment to improve the quality of drinking water and protect public health and the environment

The Sertindole Safety Survey: A retrospective analysis under a named patient use programme in Europe

<p>Abstract</p> <p>Background</p> <p>After sertindole's suspension, health authorities established a specific named-patient use (NPU) programme in order to supply sertindole to patients who did not respond to or did not tolerate alternative treatments. This programme provided the possibility of prospectively following an exhaustive cohort of patients treated with sertindole after its suspension. A survey was performed to assess sertindole's modalities of prescription, assess and document any serious adverse events (SAEs), and assess the mortality rate within the NPU cohort.</p> <p>Methods</p> <p>The study comprised a survey of sertindole-treated patients in eleven European countries. All patients treated with sertindole within the NPU programme were eligible for the study.</p> <p>Results</p> <p>1,432 patients were included in the study. The reason for sertindole prescription was lack of efficacy (approximately 50%) or adverse events (approximately 20%) of other antipsychotic treatments. The mean sertindole dose was 13.4 mg daily. Lack of efficacy and adverse events were reported as reasons for sertindole discontinuation.</p> <p>A total of 97 SAEs were recorded, including ten fatal outcomes, which occurred during the study period or within thirty days after sertindole discontinuation. The all-cause mortality rate was 0.51 per 100 Person-Years of Exposure (95% Poisson confidence interval: 0.23–0.97). QTc prolongation was reported in 15 patients (1.05% of total patients), being a rate of 0.85 per 100 Person-Years of Exposure [95% CI: 0.48–1.41].</p> <p>Conclusion</p> <p>Although prescribing and supplying sertindole were subject to administrative constraints, a significant number of patients were treated with sertindole, thus supporting the need for sertindole in specific cases.</p> <p>Trial registration number</p> <p>Not applicable.</p

Equilibria-based probabilistic model checking for concurrent stochastic games

Probabilistic model checking for stochastic games enables formal verification of systems that comprise competing or collaborating entities operating in a stochastic environment. Despite good progress in the area, existing approaches focus on zero-sum goals and cannot reason about scenarios where entities are endowed with different objectives. In this paper, we propose probabilistic model checking techniques for concurrent stochastic games based on Nash equilibria. We extend the temporal logic rPATL (probabilistic alternating-time temporal logic with rewards) to allow reasoning about players with distinct quantitative goals, which capture either the probability of an event occurring or a reward measure. We present algorithms to synthesise strategies that are subgame perfect social welfare optimal Nash equilibria, i.e., where there is no incentive for any players to unilaterally change their strategy in any state of the game, whilst the combined probabilities or rewards are maximised. We implement our techniques in the PRISM-games tool and apply them to several case studies, including network protocols and robot navigation, showing the benefits compared to existing approaches

The Expression of Vasoactive Intestinal Peptide Receptor 1 Is Negatively Modulated by MicroRNA 525-5p

Background: The human Vasoactive Intestinal Peptide (VIP) is a neurokine with effects on the immune system where it is involved in promoting tolerance. In this context, one of its receptors, VPAC1, has been found to be down-modulated in cells of the immune network in response to activating stimuli. In particular, the bacterial liposaccaride (LPS), a strong activator of the innate immune system, induces a rapid decrease of VPAC1 expression in monocytes and this event correlates with polymorphisms in the 3'-UTR of the gene. Methodology/Principal Findings: MicroRNA 525-5p, having as putative target the 3'-UTR region of VPAC1, has been analysed for its expression in monocytes and for its role in down-modulating VPAC1 expression. We report here that miR-525-5p is promptly up-regulated in LPS-treated monocytes. This microRNA, when co-transfected in 293T cells together with a construct containing the 3'-UTR of the VPAC1 gene, significantly reduced the luciferase activity in a standard expression assay. The U937 cell line as well as primary monocytes enforced to express miR-525-5p, both down-modulate VPAC1 expression at similar extent. Conclusions/Significance: Our results show that the response to an inflammatory stimulus elicits in monocytes a rapid increase of miR-525-5p that targets a signaling pathway involved in the control of the immune homeostasis

Identifying work ability promoting factors for home care aides and assistant nurses

<p>Abstract</p> <p>Background</p> <p>In workplace health promotion, all potential resources needs to be taken into consideration, not only factors relating to the absence of injury and the physical health of the workers, but also psychological aspects. A dynamic balance between the resources of the individual employees and the demands of work is an important prerequisite. In the home care services, there is a noticeable trend towards increased psychosocial strain on employees at work. There are a high frequency of work-related musculoskeletal disorders and injuries, and a low prevalence of sustainable work ability. The aim of this research was to identify factors promoting work ability and self-efficacy in care aides and assistant nurses within home care services.</p> <p>Methods</p> <p>This study is based on cross-sectional data collected in a municipality in northern Sweden. Care aides (n = 58) and assistant nurses (n = 79) replied to a self-administered questionnaire (response rate 46%). Hierarchical multiple regression analyses were performed to assess the influence of several independent variables on self-efficacy (model 1) and work ability (model 2) for care aides and assistant nurses separately.</p> <p>Results</p> <p>Perceptions of personal safety, self-efficacy and musculoskeletal wellbeing contributed to work ability for assistant nurses (R²adj of 0.36, <it>p </it>< 0.001), while for care aides, the safety climate, seniority and age contributed to work ability (R²adj of 0.29, <it>p </it>= 0.001). Self-efficacy was associated with the safety climate and the physical demands of the job in both professions (R²adj of 0.24, <it>p </it>= 0.003 for care aides), and also by sex and age for the assistant nurses (R²adj of 0.31, <it>p </it>< 0.001).</p> <p>Conclusions</p> <p>The intermediate factors contributed differently to work ability in the two professions. Self-efficacy, personal safety and musculoskeletal wellbeing were important for the assistant nurses, while the work ability of the care aides was associated with the safety climate, but also with the non-changeable factors age and seniority. All these factors are important to acknowledge in practice and in further research. Proactive workplace interventions need to focus on potentially modifiable factors such as self-efficacy, safety climate, physical job demands and musculoskeletal wellbeing.</p