Stability of spikes in the shadow Gierer-Meinhardt system with Robin boundary conditions

We consider the shadow system of the Gierer-Meinhardt system in a smooth bounded domain RN,At=2A−A+,x, t>0, ||t=−||+Ardx, t>0 with the Robin boundary condition +aAA=0, x, where aA>0, the reaction rates (p,q,r,s) satisfy 1<p<()+, q>0, r>0, s0, 1<<+, the diffusion constant is chosen such that 1, and the time relaxation constant is such that 0. We rigorously prove the following results on the stability of one-spike solutions: (i) If r=2 and 1<p<1+4/N or if r=p+1 and 1<p<, then for aA>1 and sufficiently small the interior spike is stable. (ii) For N=1 if r=2 and 1<p3 or if r=p+1 and 1<p<, then for 0<aA<1 the near-boundary spike is stable. (iii) For N=1 if 3<p<5 and r=2, then there exist a0(0,1) and µ0>1 such that for a(a0,1) and µ=2q/(s+1)(p−1)(1,µ0) the near-boundary spike solution is unstable. This instability is not present for the Neumann boundary condition but only arises for the Robin boundary condition. Furthermore, we show that the corresponding eigenvalue is of order O(1) as 0. ©2007 American Institute of Physic

A nonlocal eigenvalue problem and the stability of spikes for reaction-diffusion systems with fractional reaction rates

We consider a nonlocal eigenvalue problem which arises in the study of stability of spike solutions for reaction-diffusion systems with fractional reaction rates such as the Sel'kov model, the Gray-Scott system, the hypercycle Eigen and Schuster, angiogenesis, and the generalized Gierer-Meinhardt system. We give some sufficient and explicit conditions for stability by studying the corresponding nonlocal eigenvalue problem in a new range of parameters

Existence and stability of hole solutions to complex Ginzburg-Landau equations

We consider the existence and stability of the hole, or dark soliton, solution to a Ginzburg-Landau perturbation of the defocusing nonlinear Schroedinger equation (NLS), and to the nearly real complex Ginzburg-Landau equation (CGL). By using dynamical systems techniques, it is shown that the dark soliton can persist as either a regular perturbation or a singular perturbation of that which exists for the NLS. When considering the stability of the soliton, a major difficulty which must be overcome is that eigenvalues may bifurcate out of the continuous spectrum, i.e., an edge bifurcation may occur. Since the continuous spectrum for the NLS covers the imaginary axis, and since for the CGL it touches the origin, such a bifurcation may lead to an unstable wave. An additional important consideration is that an edge bifurcation can happen even if there are no eigenvalues embedded in the continuous spectrum. Building on and refining ideas first presented in Kapitula and Sandstede (Physica D, 1998) and Kapitula (SIAM J. Math. Anal., 1999), we show that when the wave persists as a regular perturbation, at most three eigenvalues will bifurcate out of the continuous spectrum. Furthermore, we precisely track these bifurcating eigenvalues, and thus are able to give conditions for which the perturbed wave will be stable. For the NLS the results are an improvement and refinement of previous work, while the results for the CGL are new. The techniques presented are very general and are therefore applicable to a much larger class of problems than those considered here.Comment: 41 pages, 4 figures, submitte

Existence of symmetric and asymmetric spikes for a crime hotspot model

Copyright @ 2014 Society for Industrial and Applied MathematicsWe study a crime hotspot model suggested by Short, Bertozzi, and Brantingham in [SIAM J. Appl. Dyn. Syst., 9 (2010), pp. 462--483]. The aim of this work is to establish rigorously the formation of hotspots in this model representing concentrations of criminal activity. More precisely, for the one-dimensional system, we rigorously prove the existence of steady states with multiple spikes of the following types: (i) multiple spikes of arbitrary number having the same amplitude (symmetric spikes), and (ii) multiple spikes having different amplitude for the case of one large and one small spike (asymmetric spikes). We use an approach based on Lyapunov--Schmidt reduction and extend it to the quasilinear crime hotspot model. Some novel results that allow us to carry out the Lyapunov--Schmidt reduction are (i) approximation of the quasilinear crime hotspot system on the large scale by the semilinear Schnakenberg model, and (ii) estimate of the spatial dependence of the second component on the small scale which is dominated by the quasilinear part of the system. The paper concludes with an extension to the anisotropic case

Focal-plane wavefront sensing with the vector-Apodizing Phase Plate

Context. One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) in the optical train downstream of the instrument’s main wavefront sensor split-off. Aims. In this article we show that the vector-Apodizing Phase Plate (vAPP) coronagraph can be designed such that the coronagraphic point spread functions (PSFs) can act as wavefront sensors to measure and correct the (quasi-)static aberrations without dedicated wavefront sensing holograms or modulation by the deformable mirror. The absolute wavefront retrieval is performed with a nonlinear algorithm. Methods. The focal-plane wavefront sensing (FPWFS) performance of the vAPP and the algorithm are evaluated via numerical simulations to test various photon and read noise levels, the sensitivity to the 100 lowest Zernike modes, and the maximum wavefront error (WFE) that can be accurately estimated in one iteration. We apply these methods to the vAPP within SCExAO, first with the internal source and subsequently on-sky. Results. In idealized simulations we show that for 107 photons the root mean square (RMS) WFE can be reduced to ~ λ/1000, which is 1 nm RMS in the context of the SCExAO system. We find that the maximum WFE that can be corrected in one iteration is ~ λ/8 RMS or ~200 nm RMS (SCExAO). Furthermore, we demonstrate the SCExAO vAPP capabilities by measuring and controlling the 30 lowest Zernike modes with the internal source and on-sky. On-sky, we report a raw contrast improvement of a factor ~2 between 2 and 4 λ/D after five iterations of closed-loop correction. When artificially introducing 150 nm RMS WFE, the algorithm corrects it within five iterations of closed-loop operation. Conclusions. FPWFS with the vAPP coronagraphic PSFs is a powerful technique since it integrates coronagraphy and wavefront sensing, eliminating the need for additional probes and thus resulting in a 100% science duty cycle and maximum throughput for the target

Citrullinated human and murine MOG_35–55 display distinct biophysical and biochemical behavior

The peptide spanning residues 35 to 55 of the protein myelin oligodendrocyte glycoprotein (MOG) has been studied extensively in its role as a key autoantigen in the neuroinflammatory autoimmune disease multiple sclerosis. Rodents and nonhuman primate species immunized with this peptide develop a neuroinflammatory condition called experimental autoimmune encephalomyelitis, often used as a model for multiple sclerosis. Over the last decade, the role of citrullination of this antigen in the disease onset and progression has come under increased scrutiny. We recently reported on the ability of these citrullinated MOG35–55 peptides to aggregate in an amyloid-like fashion, suggesting a new potential pathogenic mechanism underlying this disease. The immunodominant region of MOG is highly conserved between species, with the only difference between the murine and human protein, a polymorphism on position 42, which is serine in mice and proline for humans. Here, we show that the biophysical and biochemical behavior we previously observed for citrullinated murine MOG35–55 is fundamentally different for human and mouse MOG35–55. The citrullinated human peptides do not show amyloid-like behavior under the conditions where the murine peptides do. Moreover, we tested the ability of these peptides to stimulate lymphocytes derived from MOG immunized marmoset monkeys. While the citrullinated murine peptides did not produce a proliferative response, one of the citrullinated human peptides did. We postulate that this unexpected difference is caused by disparate antigen processing. Taken together, our results suggest that further study on the role of citrullination in MOG-induced experimental autoimmune encephalomyelitis is necessary.</p