Can we see pulsars around Sgr A*? - The latest searches with the Effelsberg telescope

Radio pulsars in relativistic binary systems are unique tools to study the curved space-time around massive compact objects. The discovery of a pulsar closely orbiting the super-massive black hole at the centre of our Galaxy, Sgr A*, would provide a superb test-bed for gravitational physics. To date, the absence of any radio pulsar discoveries within a few arc minutes of Sgr A* has been explained by one principal factor: extreme scattering of radio waves caused by inhomogeneities in the ionized component of the interstellar medium in the central 100 pc around Sgr A*. Scattering, which causes temporal broadening of pulses, can only be mitigated by observing at higher frequencies. Here we describe recent searches of the Galactic centre region performed at a frequency of 18.95 GHz with the Effelsberg radio telescope.Comment: 3 pages, 2 figures, Proceedings of IAUS 291 "Neutron Stars and Pulsars: Challenges and Opportunities after 80 years", 201

Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter

Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA damage and supra-additive toxicity to NAT-expressing cells and xenografts. This combination treatment is undergoing clinical evaluation. This present study investigated the potential of PARP-1 inhibition, in vitro and in vivo, to further enhance [131I]MIBG/topotecan efficacy

Advances in the development of Astatine-radiolabelling protocols: exploring the metallic character of astatine

International audiencen.

The Monge problem in Wiener Space

We address the Monge problem in the abstract Wiener space and we give an existence result provided both marginal measures are absolutely continuous with respect to the infinite dimensional Gaussian measure {\gamma}

New Binary and Millisecond Pulsars from Arecibo Drift-Scan Searches

We discuss four recycled pulsars found in Arecibo drift-scan searches. PSR J1944+0907 has a spin period of 5.2 ms and is isolated. The 5.8-ms pulsar J1453+19 may have a low-mass companion. We discuss these pulsars in the context of isolated millisecond pulsar formation and the minimum spin period of neutron stars. The isolated 56-ms pulsar J0609+2130 is possibly the remnant of a disrupted double neutron star binary. The 41-ms pulsar J1829+2456 is in a relativistic orbit. Its companion is most likely another neutron star, making this the eighth known double neutron star binary system.Comment: 6 pages, 3 figures, to appear in proceedings of Aspen Center for Physics Conference on ``Binary Radio Pulsars'' Eds. F. Rasio and I. Stair

Pearl millet and iron in the West African Sahel: Archaeobotanical investigation at Tongo Maaré Diabal, Mali

Recent archaeobotanical analysis revealed that the botanical remains from the site of Tongo Maaré Diabal (Mali) are composed primarily of pearl millet remains (up to 85%). Contemporaneous West African sites (500–1200 Cal AD) usually display more diverse patterns, especially by the end of this period. Indeed, contemporary urban sites of the West African Sahel often comprise combined and diversified farming systems of millet (Pennisetum glaucum), African rice (Oryza glaberrima), sorghum (Sorghum bicolor), Echinochloa sp. and fonio (Digitatia exilis). This article seeks to explain the near-exclusive focus of Tongo Maaré Diabal’s agricultural economy on millet, particularly with regard to the site’s status as a settlement of iron workers

The High Time Resolution Universe Survey - V: Single-pulse energetics and modulation properties of 315 pulsars

We report on the pulse-to-pulse energy distributions and phase-resolved modulation properties for catalogued pulsars in the southern High Time Resolution Universe intermediate-latitude survey. We selected the 315 pulsars detected in a single-pulse search of this survey, allowing a large sample unbiased regarding any rotational parameters of neutron stars. We found that the energy distribution of many pulsars is well-described by a log-normal distribution, with few deviating from a small range in log-normal scale and location parameters. Some pulsars exhibited multiple energy states corresponding to mode changes, and implying that some observed "nulling" may actually be a mode-change effect. PSRJ1900-2600 was found to emit weakly in its previously-identified "null" state. We found evidence for another state-change effect in two pulsars, which show bimodality in their nulling time scales; that is, they switch between a continuous-emission state and a single-pulse-emitting state. Large modulation occurs in many pulsars across the full integrated profile, with increased sporadic bursts at leading and trailing sub-beam edges. Some of these high-energy outbursts may indicate the presence of "giant pulse" phenomena. We found no correlation with modulation and pulsar period, age, or other parameters. Finally, the deviation of integrated pulse energy from its average value was generally quite small, despite the significant phase-resolved modulation in some pulsars; we interpret this as tenuous evidence of energy regulation between distinct pulsar sub-beams.Comment: Before full MNRAS publication, supplementary material is available temporarily at http://dl.dropbox.com/u/22076931/supplementary_material.pd