253 research outputs found
Waves and Solitons in the Continuum Limit of the Calogero-Sutherland Model
We examine a collection of particles interacting with inverse-square two-body
potentials in the thermodynamic limit. We find explicit large-amplitude density
waves and soliton solutions for the motion of the system. Waves can be
constructed as coherent states of either solitons or phonons. Therefore, either
solitons or phonons can be considered as the fundamental excitations. The
generic wave is shown to correspond to a two-band state in the quantum
description of the system, while the limiting cases of solitons and phonons
correspond to particle and hole excitations.Comment: Version to appear in Physical Rerview Letters; contains some new
results and explanation
A platform in the use of medicines to treat chronic hepatitis C (PLATINUM C) protocol for a prospective treatment registry of real world o
Background
Safe, highly curative, short course, direct acting antiviral (DAA) therapies are now available to treat chronic hepatitis C. DAA therapy is freely available to all adults chronically infected with the hepatitis C virus (HCV) in Australia. If left untreated, hepatitis C may lead to progressive hepatic fibrosis, cirrhosis and hepatocellular carcinoma. Australia is committed to eliminating hepatitis as a public health threat by 2030 set by the World Health Organization. However, since the introduction of funded DAA treatment, uptake has been suboptimal. Australia needs improved strategies for testing, treatment uptake and treatment completion to address the persisting hepatitis C public health problem. PLATINUM C is a HCV treatment registry and research platform for assessing the comparative effectiveness of alternative interventions for achieving virological cure.
Methods
PLATINUM C will prospectively enrol people with active HCV infection confirmed by recent detection of HCV ribonucleic acid (RNA) in blood. Those enrolled will agree to allow standardised collection of demographic, lifestyle, treatment, virological outcome and other relevant clinical data to better inform the future management of HCV infection. The primary outcome is virological cure evidenced by sustained virological response (SVR), which is defined as a negative HCV PCR result 6 to 18 months after initial prescription of DAA therapy and no less than 12 weeks after the completion of treatment. Study participants will be invited to opt-in to medication adherence monitoring and quality of life assessments using validated self-reported instruments (EQ-5D-5L).
Discussion
PLATINUM C is a treatment registry and platform for nesting pragmatic trials. Data collected will inform the design, development and implementation of pragmatic trials. The digital infrastructure, study procedures and governing systems established by the registry will allow PLATINUM C to support a wider research platform in the management of hepatitis C in primary care.
Trial registration
The trial is registered with the Australia and New Zealand Clinical Trials Register (ACTRN12619000023156). Date of registration: 10/01/2019
Survey of electronic properties and local structures around Fe in selected multinary chalcogenides
Paper presents detailed studies of local and electronic structure around Fe in Cd0.97Fe0.03Te, Cd0.98Fe0.02Te0.97Se0.03 and Cd0.99Fe0.01Te0.91S0.09 multinary chalcogenides by means of X ray absorption fine structure XAFS , X ray magnetic circular dichroism XMCD and electron paramagnetic resonance EPR measurements. In addition, electronic consequences of Fe incorporation into CdTe semiconductor host were studied by means of first principles calculations. In order to improve accuracy of the calculated total energies, the band gaps and the band edge positions, special attention is paid to the treatment of exchange correlation interaction and the description of highly localized Fe 3d states. Also, the Bader theory of the topological properties of the electron charge density is used to access details of the nature, strength and distribution of the next nearest neighbour bonds. Local and electronic structure around Fe in Cd0.97Fe0.03Te and Cd0.98Fe0.02Te0.97Se0.03 systems have been found to exhibit similar characteristics, since the first coordination sphere around Fe comprises four Te atoms located at approximately the same distance. In Cd0.99Fe0.01Te0.91S0.09 system, however, local bimodal distribution of distances has been revealed, with one Fe Te bond replaced with much shorter Fe S bond, resulting in much stronger crystal field. Along with the crystal field effect, the spin orbit interaction has proven to play decisive role in determining the nature of Fe doped CdTe systems. While the systems with higher Fe concentrations 25 at. are intrinsic insulators, in systems with only 3.125 at. Fe one spin channel contributes to the density of states at the Fermi level, which makes them suitable for spin selective electronic transport application
Equivalence of the Calogero-Sutherland Model to Free Harmonic Oscillators
A similarity transformation is constructed through which a system of
particles interacting with inverse-square two-body and harmonic potentials in
one dimension, can be mapped identically, to a set of free harmonic
oscillators. This equivalence provides a straightforward method to find the
complete set of eigenfunctions, the exact constants of motion and a linear
algebra associated with this model. It is also demonstrated that
a large class of models with long-range interactions, both in one and higher
dimensions can be made equivalent to decoupled oscillators.Comment: 9 pages, REVTeX, Completely revised, few new equations and references
are adde
A Unified Algebraic Approach to Few and Many-Body Correlated Systems
The present article is an extended version of the paper {\it Phys. Rev.} {\bf
B 59}, R2490 (1999), where, we have established the equivalence of the
Calogero-Sutherland model to decoupled oscillators. Here, we first employ the
same approach for finding the eigenstates of a large class of Hamiltonians,
dealing with correlated systems. A number of few and many-body interacting
models are studied and the relationship between their respective Hilbert
spaces, with that of oscillators, is found. This connection is then used to
obtain the spectrum generating algebras for these systems and make an algebraic
statement about correlated systems. The procedure to generate new solvable
interacting models is outlined. We then point out the inadequacies of the
present technique and make use of a novel method for solving linear
differential equations to diagonalize the Sutherland model and establish a
precise connection between this correlated system's wave functions, with those
of the free particles on a circle. In the process, we obtain a new expression
for the Jack polynomials. In two dimensions, we analyze the Hamiltonian having
Laughlin wave function as the ground-state and point out the natural emergence
of the underlying linear symmetry in this approach.Comment: 18 pages, Revtex format, To appear in Physical Review
On The Problem of Particle Production in c=1 Matrix Model
We reconsider and analyze in detail the problem of particle production in the
time dependent background of matrix model where the Fermi sea drains away
at late time. In addition to the moving mirror method, which has already been
discussed in hep-th/0403169 and hep-th/0403275, we describe yet another method
of computing the Bogolubov coefficients which gives the same result. We
emphasize that these Bogolubov coefficients are approximately correct for small
value of the deformation parameter.
We also study the time evolution of the collective field theory stress-tensor
with a special point-splitting regularization. Our computations go beyond the
approximation of the previous treatments and are valid at large coordinate
distances from the boundary at a finite time and up-to a finite coordinate
distance from the boundary at late time. In this region of validity our
regularization produces a certain singular term that is precisely canceled by
the collective field theory counter term in the present background. The energy
and momentum densities fall off exponentially at large distance from the
boundary to the values corresponding to the static background. This clearly
shows that the radiated energy reaches the asymptotic region signaling the
space-time decay.Comment: 37 pages, 5 figures. Section 6 is modified to clarify main
accomplishments of the paper including a discussion comparing stress-tensor
analysis with those preexisted in literature. Other modifications include
minor changes in the text and addition of one reference. Version accepted for
publication in JHE
Genetic Dissection of Epidermal Growth Factor Receptor Signaling during Luteinizing Hormone-Induced Oocyte Maturation
Recent evidence that luteinizing hormone (LH) stimulation of ovulatory follicles causes transactivation of the epidermal growth factor receptor (EGFR) has provided insights into the mechanisms of ovulation. However, the complete array of signals that promote oocyte reentry into the meiotic cell cycle in the follicle are still incompletely understood. To elucidate the signaling downstream of EGFR involved in oocyte maturation, we have investigated the LH responses in granulosa cells with targeted ablation of EGFR. Oocyte maturation and ovulation is disrupted when EGFR expression is progressively reduced. In granulosa cells from mice with either global or granulosa cell-specific disruption of EGFR signaling, LH-induced phosphorylation of MAPK3/1, p38MAPK, and connexin-43 is impaired. Although the LH-induced decrease in cGMP is EGFR-dependent in wild type follicles, LH still induces a decrease in cGMP in Egfrdelta/f Cyp19-Cre follicles. Thus compensatory mechanisms appear activated in the mutant. Spatial propagation of the LH signal in the follicle also is dependent on the EGF network, and likely is important for the control of signaling to the oocyte. Thus, multiple signals and redundant pathways contribute to regulating oocyte reentry into the cell cycle
Antiepileptic drugs’ tolerability and safety – a systematic review and meta-analysis of adverse effects in dogs
<p>Various anti-epileptic drugs (AEDs) are used for the management of idiopathic epilepsy (IE) in dogs. Their safety profile is an important consideration for regulatory bodies, owners and prescribing clinicians. However, information on their adverse effects still remains limited with most of it derived from non-blinded non-randomized uncontrolled trials and case reports.</p><p><span>This poster won third place, which was presented at the Veterinary Evidence Today conference, Edinburgh November 1-3, 2016. </span></p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /
- …