The study of the psychological characteristics of the pharmacist's personality in the aspect of the corporate culture of the pharmacy organization

The article presents the results of a study of the pharmacist's personality in the context of corporate culture, on the basis of which a comprehensive program for the development of the personal potential of employees of pharmacy organizations was developed. The sample consisted of 70 specialists (pharmacists) working in pharmacy chains in the city of Nizhny Novgorod. The results of the study indicated significant changes that occurred in the experimental and control groups according to all the analysed criteria. The significance of the results obtained for science is to expand the understanding of the multidimensional personality qualities of pharmacists required by representatives of this profession, which allows us to study this phenomenon in more detail, to explain some features of the personality of pharmacists, on whose professionalism depends the quality of the work performed, and hence the health of society

Psychological features of personal development of younger adolescents in the process of leisure activities

The article presents the results of analysis of younger adolescents’ psychological characteristics and provides a description of a comprehensive program created in order to ensure effective personal development of children in this age group in the process of carrying out leisure activities. To test the program, a sample was formed consisting of 60 adolescents studying at Municipal Budgetary General Education Institution “School No. 134” in Nizhny Novgorod. The results of the study indicate significant changes among all criteria analyzed for the experimental and the control groups. The scientific significance of the data obtained lies in the expansion of the idea of younger adolescents’ personal qualities’ multidimensionality and the opportunity provided to study the phenomenon in more detail. Indicators obtained during the course of the study can be used to organise extracurricular activities for adolescents, hold seminars and personal development trainings as well as develop methodological manuals on personality psychology

Psychosemantic analysis of eye care workers’ percepts of creative abilities

Background: This article puts the emphasis on the notion of “creative abilities” in the context of its interpretation by eye care workers. Creative potential is essential for the general and professional culture of physicians, and personal creativity takes on a new meaning in the age of digitalization and dominance of artificial intelligence in routine medical practice. Purpose: To investigate eye care workers’ percepts of creative abilities by conducting a psychosemantic analysis and considering these percepts as a source of health care workers’ job satisfaction. Material and Methods: The study sample was composed of the eye care workers from the Filatov Institute of Eye Diseases. Two hundred and eleven eye care workers were requested to take part in the study, and the response rate was 85.8% (181/211). The 181 responders included 99 nursing staff members and 82 physicians (ophthalmologists). The study was conducted with the use of Hughes and Powell’s Guiding Principles for Life (GPL) Questionnaire (adapted by Semeniuk), the Kim, Leong, and Lee’s Job Satisfaction Scale (JSS) (adapted by Semeniuk) and the Lüscher 8-color test. Results: Eye care workers rated “Creativity” low among the 22 “Guiding Principles for Life”. In physicians, such guiding principles as “Creativity”, “Devout”, and “Material wealth” were associated with each other, which indicates that the achievement of material wealth was associated with such a virtue as devout, and this achievement requires creativity. It was demonstrated that creativity as a guiding principle was more important for physicians than for the nursing staff, and in male physicians it was associated with unconscious satisfaction with working environment

Mg2+ activation of Escherichia coli inorganic pyrophosphatase

AbstractFurther refinement of X-ray data on Escherichia coli inorganic pyrophosphatase [Oganessyan et al. (1994) FEBS Lett. 348, 301–304] to 2.2 Å reveals a system of noncovalent interactions involving Tyr55 and Tyr141 in the active site. The pKa for one of the eight Tyr residues in wild-type pyrophosphatase is as low as 9.1 and further decreases to 8.1 upon Mg2+ binding, generating characteristic changes in the absorption spectrum. These effects are lost in a Y55F but not in a Y141F variant. It is suggested that the lower-affinity site for Mg2+ in the enzyme is formed by Tyr55 and Asp70, which are in close proximity in the apo-enzyme structure

Addressing the exciton fine structure in colloidal nanocrystals: the case of CdSe nanoplatelets

We study the band-edge exciton fine structure and in particular its bright-dark splitting in colloidal semiconductor nanocrystals by four different optical methods based on fluorescence line narrowing and time-resolved measurements at various temperatures down to 2 K. We demonstrate that all these methods provide consistent splitting values and discuss their advances and limitations. Colloidal CdSe nanoplatelets with thicknesses of 3, 4 and 5 monolayers are chosen for experimental demonstrations. The bright-dark splitting of excitons varies from 3.2 to 6.0 meV and is inversely proportional to the nanoplatelet thickness. Good agreement between experimental and theoretically calculated size dependence of the bright-dark exciton slitting is achieved. The recombination rates of the bright and dark excitons and the bright to dark relaxation rate are measured by time-resolved techniques

Visual novels as modern-day electronic editions in Japan, USA and Russia

Статья посвящена анализу нового вида электронных изданий, широко распространяющихся в мире в последние 25 лет, – визуальных новелл. В статье делается попытка определить их место в типологии электронной издательской продукции, выделяются жанровые особенности оригинальных японских визуальных новелл и изданий, возникших как производные от них, в США и России.The article is dedicated to the analysis of the new type of electronic publications, which have been widely spreading around the world in the recent 25 years – visual novels. In this article it is attempted to determine their place in the typology of electronic publishing products, to highlight features of original Japanese visual novels as genre and also features of editions which developed as visual novels’ derivative in the USA and Russia

Developing a scale for assessing coping behavior in situations of danger

Background: The paper is focused on developing a psychodiagnostic tool for assessing coping behavior in situations of danger. Studies of coping behavior became increasingly important with the beginning of the Russian invasion in Ukraine on February 24, 2022. The version developed may become a reliable auxiliary tool for assessing the adaptive capacity of the personality, which is believed to be promising and of increasing importance for further studies. Purpose: To develop a psychodiagnostic tool for assessing coping behavior in danger situations to improve the adaptive capacity of the personality. Material and Methods: The study sample was composed of 311 responders (165 men and 146 women; mean age, 33.7 years). The study was conducted with the use of the seven-factor model of the Ways of Coping Questionnaire (WOCQ) as modified by Rodina. R-Studio software (version 1.4.1717) was used for statistical analyses of the questionnaire which included exploratory and confirmatory factor analysis, structural equation modeling, scale reliability analysis, correlation analysis and descriptive statistic analysis. Results: The Ukrainian-language five-factor model of the Scale for Assessing Coping Behavior in Situations of Danger developed includes the following subscales: Acceptance and Passive Reliance on Support, Acceptance and Passive Pessimism, Acceptance and Passive Optimism, Acceptance and Active Fighting, and Non-Acceptance and Dissociation. Application of the method for assessing coping behavior in situations of danger is promising and of increasing importance for further studies in order to improve the adaptive capacity of the personality

Assay strategies for the discovery and validation of therapeutics targeting <i>Brugia pahangi</i> Hsp90

The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm. The identification of compounds that target adult worms has been a long-term goal of WHO. Here we describe a fluorescence polarization assay for the identification of compounds that target Hsp90 in adult filarial worms. The assay was originally developed to identify inhibitors of Hsp90 in tumor cells, and relies upon the ability of small molecules to inhibit the binding of fluorescently labelled geldanamycin to Hsp90. We demonstrate that the assay works well with soluble extracts of Brugia, while extracts of the free-living nematode C. elegans fail to bind the probe, in agreement with data from other experiments. The assay was validated using known inhibitors of Hsp90 that compete with geldanamycin for binding to Hsp90, including members of the synthetic purine-scaffold series of compounds. The efficacy of some of these compounds against adult worms was confirmed in vitro. Moreover, the assay is sufficiently sensitive to differentiate between binding of purine-scaffold compounds to human and Brugia Hsp90. The assay is suitable for high-throughput screening and provides the first example of a format with the potential to identify novel inhibitors of Hsp90 in filarial worms and in other parasitic species where Hsp90 may be a target