Magnetoimpedance in symmetric and non-symmetric nanostructured multilayers: A theoretical study

Intensive studies of the magnetoimpedance (MI) effect in nanostructured multilayers provide a good phenomenological basis and theoretical description for the symmetric case when top and bottom layers of ferromagnet/conductor/ferromagnet structure have the same thickness and consist of one magnetic layer each. At the same time, there is no model to describe the MI response in multilayered films. Here, we propose the corresponding model and analyze the influence of the multilayer parameters on the field and frequency dependences of the MI. The approach is based on the calculation of the field distribution within the multilayer by means of a solution of lineralizied Maxwell equations together with the Landau–Lifshitz equation for the magnetization motion. The theoretical model developed allows one to explain qualitatively the main features of the MI effect in multilayers and could be useful for optimization of the film parameters. It might also be useful as a model case for the development of MI magnetic biosensors for magnetic biomarker detection. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.Russian Science Foundation: 18-19-00090Funding: This research was funded by the Russian Science Foundation, grant number 18-19-00090

Off-diagonal magnetoimpedance in field-annealed Co-based amorphous ribbons

The off-diagonal magnetoimpedance in field-annealed CoFeSiB amorphous ribbons was measured in the low-frequency range using a pick-up coil wound around the sample. The asymmetric two-peak behavior of the field dependence of the off-diagonal impedance was observed. The asymmetry is attributed to the formation of a hard magnetic crystalline phase at the ribbon surface. The experimental results are interpreted in terms of the surface impedance tensor. It is assumed that the ribbon consists of an inner amorphous region and surface crystalline layers. The coupling between the crystalline and amorphous phases is described through an effective bias field. A qualitative agreement between the calculated dependences and experimental data is demonstrated. The results obtained may be useful for development of weak magnetic-field sensors.Comment: 19 pages, 6 figure

Generation of second harmonic in off-diagonal magneto-impedance in Co-based amorphous ribbons

The off-diagonal magneto-impedance in Co-based amorphous ribbons was measured using a pick-up coil wound around the sample. The ribbons were annealed in air or in vacuum in the presence of a weak magnetic field. The evolution of the first and second harmonics in the pick-up coil voltage as a function of the current amplitude was studied. At low current amplitudes, the first harmonic dominates in the frequency spectrum of the voltage, and at sufficiently high current amplitudes, the amplitude of the second harmonic becomes higher than that of the first harmonic. For air-annealed ribbons, the asymmetric two-peak behaviour of the field dependences of the harmonic amplitudes was observed, which is related to the coupling between the amorphous phase and surface crystalline layers appearing after annealing. For vacuum-annealed samples, the first harmonic has a maximum at zero external field, and the field dependence of the second harmonic exhibits symmetric two-peak behaviour. The experimental results are interpreted in terms of a quasi-static rotational model. It is shown that the appearance of the second harmonic in the pick-up coil voltage is related to the anti-symmetrical distribution of the transverse field induced by the current. The calculated dependences are in a qualitative agreement with the experimental data.Comment: 16 pages, 4 figure

A Model for the Magnetoimpedance Effect in Non-Symmetric Nanostructured Multilayered Films with Ferrogel Coverings

Magnetoimpedance (MI) biosensors for the detection of in-tissue incorporated magnetic nanoparticles are a subject of special interest. The possibility of the detection of the ferrogel samples mimicking the natural tissues with nanoparticles was proven previously for symmetric MI thin-film multilayers. In this work, in order to describe the MI effect in non-symmetric multilayered elements covered by ferrogel layer we propose an electromagnetic model based on a solution of the 4Maxwell equations. The approach is based on the previous calculations of the distribution of electromagnetic fields in the non-symmetric multilayers further developed for the case of the ferrogel covering. The role of the asymmetry of the film on the MI response of the multilayer–ferrogel structure is analyzed in the details. The MI field and frequency dependences, the concentration dependences of the MI for fixed frequencies and the frequency dependence of the concentration sensitivities are obtained for the detection process by both symmetric and non-symmetric MI structures. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This research was funded by the University Basque Country UPV/EHU, Research Groups Funding (IT1245-19)

Functional magnetic ferrogels: From biosensors to regenerative medicine

Polyelectrolyte gels and ferrogels (FG) are attracting special interest in biomedicine. Here we describe our experience developing functional magnetic ferrogels for regenerative medicine and magnetoimpedance biosensing for measuring stray fields of nanoparticles in FG with a multilayered sensitive element. We discuss the possibility of developing a new generation of drug delivery systems for magnetic field assisted delivery, positioning and biosensing. © 2020 Author(s).This work was supported by the RSF project 18-19-00090. We thank O.M. Samatov, B. Stadler, V.N. Lepalovskij, M.A. Korch, A.V. Svalov, D.G. Blisnets, A. Larrañaga, I. Orue, and M.N. Volochaev for support. Selected measurements were made at SGIKER UPV/EHU

Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation

Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a wide variety of physiological responses, including apoptosis, cellular proliferation and neuronal differentiation. However, the intracellular mechanisms underlying these effects of AChR signaling are not fully understood. It is known that activation of AChRs increase cellular proliferation and neurogenesis and that regulation of intracellular calcium through AChRs may underlie the many functions of ACh. Intriguingly, activation of diverse signaling molecules such as Ras-mitogen-activated protein kinase, phosphatidylinositol 3-kinase-Akt, protein kinase C and c-Src is modulated by AChRs. Here we discuss the roles of ACh in neuronal differentiation, cell proliferation and apoptosis. We also discuss the pathways involved in these processes, as well as the effects of novel endogenous AChRs agonists and strategies to enhance neuronal-differentiation of stem and neural progenitor cells. Further understanding of the intracellular mechanisms underlying AChR signaling may provide insights for novel therapeutic strategies, as abnormal AChR activity is present in many diseases

Ontogeny of central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui

Embryonic development of the central serotonergic neurons in the directly developing frog, Eleutherodactylus coqui , was determined by using immunocytochemistry. The majority of anuran amphibians (frogs) possess a larval stage (tadpole) that undergoes metamorphosis, a dramatic post-embryonic event, whereby the tadpole transforms into the adult phenotype. Directly developing frogs have evolved a derived life-history mode where the tadpole stage has been deleted and embryos develop directly into the adult bauplan. Embryonic development in E. coqui is classified into 15 stages (TS 1–15; 1 = oviposition / 15 = hatching). Serotonergic immunoreactivity was initially detected at TS 6 in the raphe nuclei in the developing rhombencephalon. At TS 7, immunopositive perikarya were observed in the paraventricular organ in the hypothalamus and reticular nuclei in the hindbrain. Development of the serotonergic system was steady and gradual during mid-embryogenesis. However, starting at TS 13 there was a substantial increase in the number of serotonergic neurons in the paraventricular, raphe, and reticular nuclei, a large increase in the number of varicose fibers, and a differentiation of the reticular nuclei in the hindbrain. Consequentially, E. coqui displayed a well-developed central serotonergic system prior to hatching (TS 15). In comparison, the serotonergic system in metamorphic frogs typically starts to develop earlier but the surge of development that transpires in this system occurs post-embryonically, during metamorphosis, and not in the latter stages of embryogenesis, as it does in E. coqui . Overall, the serotonergic development in E. coqui is similar to the other vertebrates.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47526/1/429_2005_Article_22.pd

Modeling of magnetoimpedance effect in nanostructured multilayered films

The magnetoimpedance effect in nanostructured multilayers is studied theoretically. The multi-layered film structure consists of highly conductive non-magnetic central layer and two external multilayers containing soft magnetic layers of the same thickness separated either by magnetic spacers of different kind or by non-magnetic spacers. In order to describe the magnetoimpedance in the multilayer an electrodynamic model is proposed. The influence of geometric parameters and physical properties of the layers on the magnetoimpedance response is analyzed. The results obtained could be useful both for better understanding of high-frequency behavior of nanostructured multilayers and for optimization of multilayer parameters aiming to enhance the magnetoimpedance effect for practical applications. © Published under licence by IOP Publishing Ltd.Russian Science Foundation, RSF: 18-19-00090This research was funded by the Russian Science Foundation, grant number 18-19-00090