New Nanomaterials and Luminescent Optical Sensors for Detection of Hydrogen Peroxide

Accurate methods that can continuously detect low concentrations of hydrogen peroxide (H2O2) have a huge application potential in biological, pharmaceutical, clinical and environmental analysis. Luminescent probes and nanomaterials are used for fabrication of sensors for H2O2 that can be applied for these purposes. In contrast to previous reviews focusing on the chemical design of molecular probes for H2O2, this mini-review highlights the latest luminescent nanoparticular materials and new luminescent optical sensors for H2O2 in terms of the nanomaterial composition and luminescent receptor used in the sensors. The nanomaterial section is subdivided into schemes based on gold nanoparticles, polymeric nanoparticles with embedded enzymes, probes showing aggregation-induced emission enhancement, quantum dots, lanthanide-based nanoparticles and carbon based nanomaterials, respectively. Moreover, the sensors are ordered according to the type of luminescent receptor used within the sensor membranes. Among them are lanthanide complexes, metal-ligand complexes, oxidic nanoparticles and organic dyes. Further, the optical sensors are confined to those that are capable to monitor the concentration of H2O2 in a sample over time or are reusable. Optical sensors responding to gaseous H2O2 are not covered. All nanomaterials and sensors are characterized with respect to the analytical reaction towards H2O2, limit of detection (LOD), analytical range, electrolyte, pH and response time/incubation time. Applications to real samples are given. Finally, we assess the suitability of the nanomaterials to be used in membrane-based sensors and discuss future trends and perspectives of these sensors in biomedical research

Advancing Teaching Mathematics in Students at Universities of Economics for Sustainable Development

The article is devoted to the advanced nature of education for sustainable development. The research urgency is caused by necessity of formation of strategy of education for sustainable development in Russian higher education. A review of the most important international documents is made (Strategy of European Economic Commission of the UN of education for sustainable development, Global action programme on ESD, Incheon Declaration of “Education-2030,” Program of sustainable development for the period till 2030, etc.), allowing to concretize the principles of education for sustainable development. Special attention is paid to the principle of advancing training in terms of organization of training in mathematics at the University of Economics. As a means of implementing the principle of advancing teaching of mathematics it is proposed to use the method of mathematical modelling as a promising direction of research and problem solving in the economic sphere of activities in favour of sustainable development. The author noted the importance of the ability to build and use mathematical models to describe and predict real processes, which in turn, demonstrates the possibility of forming a transformative intelligence as readiness for integrated use of intuition, logical thinking and quantitative assessments to develop the skills of creative solutions to life and professional problems in the conditions of variability and uncertainty

Simultaneous electrical conductivity and DTA measurements in the study of the phosphonate-phosphate rearrangement and accompanying processes

The application of DTA with the simultaneous recording of electrical conductivity variation in the study of the thermal behaviour of α-oxyalkylphosphonates and their analogues is considered. The investigation of electrical conductivity variation during a reaction helps clarify certain problems of the phosphonate-phosphate rearrangement and the decomposition of α-oxyalkylphosphonates to their components. © 1974 Wiley Heyden Ltd., Chichester and Akadémiai Kiadó, Budapest

Immunogenetic profile of MIC (A, B) HLA loci linked to MHC antigenic complex in Russians of the Chelyabinsk Region

The MIC genes are located on chromosome 6 in the class I major histocompatibility complex (MHC) region and encode a membrane-bound stress-inducible protein that acts as a ligand to stimulate the NKG2D activating receptor expressed on the surface of the most natural killer cells (NK). Currently, 7 MIC loci are known, of which only MICA and MICB encode proteins and show a significant allelic polymorphism. The MIC gene polymorphism and their location in the HLA region suggests presence of some ethnic and populational differences for the gene frequencies, linkage disequilibrium of distinct loci, and distribution of HLA-MIC haplotypes, thus making it possible to get information on genetic relationship of human populations. The aim of our study was to assess immunogenetic profile of Russian population in Chelyabinsk Region based on the non-classical HLA loci, i.e., MICA and MICB, in the context of worldwide population data. Methods of the study included immunogenetic typing of 100 donors identifying themselves as Russians, taken from the Registry of Stem Cell Donors at the Chelyabinsk Regional Blood Transfusion Station. The 2 loci (MICA and MICB) were typed at basic resolution, using PCR technique with sequence-specific primers (SSP-PCR). Gene frequencies (GF) were calculated using programs for immunogenetic research (Arlequin 3.5).Among Russian population from Chelyabinsk Region, the following characteristics of the MICA gene distributions were found: MICA *008, *002, *010, *009, frequency of > 7%; average frequencies, for MICA *004, *007, *018, *017; whereas MICA *027, *011, *006, *009:02, *049, *012, *016 was registered at a frequency of < 3.5%. MICB gene profile was as follows: MICB *005:02, *004, *002, *008 at a frequency of > 6%; at a frequency of 4% MICB *003, *005:03; MICB *005:01, * 005:04, * 009N, MICB *013, *014 at a frequency of0.5%. As based on calculated genetic distances (according to Ney) for the MICA locus, the dendrogram and scatter plot were designed by means of multidimensional scaling (MDS) method, presenting location of 30 world populations, including data on Russians in Chelyabinsk Region. The smallest genetic distances between the population of Russians from Chelyabinsk Region and other world populations were found between the population of Slovenia, as well as the USA population of European origin. As based on scatterplot obtained by the MDS approach for MICA gene frequencies, using the data of cluster analysis, we have found that the population of Russians from Chelyabinsk Region belongs to a cluster of typical European populations.The obtained patterns could be used for practical purposes to create a registry of stem cell donors in Russia. In addition, the data may be used as a control group for further research in the area of HLA-disease association, and could be also demanded by the specialists in population ethnogenesis

Using Machine Vision to Improve the Efficiency of Lumber Mills

This work provides rationale for the implementation of a machine vision-based approach for promoting timber processing efficiency. With efforts to combat the climate change, criteria for the success of wood industries shifted. Now, they need to ensure economic efficiency while taking the reduction in carbon intensity into account. This may be achieved in either of two ways, through the improvement of energy efficiency in production and by minimizing waste. So far, the traditional methods for the improvement of timber processing efficiency became obsolete. Hence, using advances in electronic engineering and machine vision may be viewed as a promising step. © Published under licence by IOP Publishing Ltd

From the experience of health and restoring the health of modern preschoolers 6-7 years in the MDOU

В работе предоставлен многолетний опыт совместного сотрудничества МДОУ № 5 и кафедры МБД МГОСГИ по вопросам здоровьесбережения и реабилитации нарушений осанки и стопы у метеозависимых детей 6-7 летGiven the long experience of joint cooperation MDOU № 5 of MDB MGOSGI health and rehabilitation of posture and foot weather dependent children 6-7 year

ПРЕДМЕТНАЯ КОМПЕТЕНТНОСТЬ В СИСТЕМЕ МНОГОУРОВНЕВОГО ВЫСШЕГО ЭКОНОМИЧЕСКОГО ОБРАЗОВАНИЯ

The article discusses the issue of building subject competence of students in multilevel higher economic education system settings. The authors reveal the factors dictating the need for content implementation of competence-based approach through training subject. The paper explains the expediency of the idea of advanced training in terms of the leading position of competence-based approach in the multi-paradigmatic modern educational environment. It describes the experience of the Financial University under the Government of the Russian Federation in developing and implementing an educational standard for teaching “Economics” based on the disciplines included in the subject “Mathematics”, it shows the possibility of designing the educational process taking into account the perceived importance of individual competences. It shows the results of a sociological survey of regional employers requirements in order to specify learning outcomes as a cluster of generated competencies.В статье обсуждается проблема формирования предметной компетентности студентов в условиях многоуровневого высшего экономического образования. Выделены факторы, обусловливающие необходимость содержательной реализации компетентностного подхода средствами предметной подготовки. Обоснована целесообразность идеи опережающего обучения с точки зрения ведущей позиции компетентностного подхода в условиях полипарадигмальности современного образовательного пространства. Представлен опыт Финансового университета при Правительстве РФ в разработке и внедрении в практику обучения Образовательного стандарта высшего образования по направлению «Экономика», определяющего возможность проектирования образовательного процесса в соответствии с «весовым коэффициентом» важности отдельных компетенций на примере дисциплин предметной области «Математика». Продемонстрированы результаты социологического исследования требований региональных работодателей с целью конкретизации результатов образования в виде кластера формируемых компетенций

ПРОЕКТНО-КОНТЕКСТНОЕ ОБРАЗОВАНИЕ В РЕАЛИЗАЦИИ МНОГОУРОВНЕВОЙ ПОДГОТОВКИ ЭКОНОМИСТОВ

The dynamics of modern society and the growth of innovative economy needs lead to shortening of graduates’ periods of adaptation to professional activity, growing of their mobility, competitiveness, and make the professional education face new tasks.Authors discuss the problem of multilevel economic education organization, aimed at elimination of the gap between employers requirements and assignable educational services. The necessity of development of projectcontextual education technology is being proved. It creates an opportunity of competence approach realization. In the article Financial University’s experience is showed to develop and introduce the educational standard „Economics” in the practice of training personnel for innovative economy. This experience defi nes the opportunity of designing the educational process according to „weighting coeffi cient” of particular competences importance and systematic unity of higher education levels. Динамичность современного общества, рост потребностей инновационной экономики обусловливают сокращение сроков адаптации выпускников вузов к профессиональной деятельности, повышение их мобильности, конкурентоспособности и ставят перед профессиональным образованием новые задачи. Авторами обсуждается проблема организации многоуровневого экономического образования, направленного на устранение разрыва между требованиями работодателей и предоставляемыми образовательными услугами. Обоснована необходимость разработки технологии проектно-контекстного обучения, создающей возможность содержательной реализации компетентностного подхода.Представленный в статье опыт Финансового университета при Правительстве РФ по разработке и внедрению Образовательного стандарта высшего образования по направлению «Экономика» в практику подготовки кадров для инновационной экономики определяет возможность проектирования образовательного процесса в соответствии с «весовым коэффициентом» важности отдельных компетенций и системном единстве уровней высшего образования.

Особенности проявления нейротоксичности некоторых комбинаций препаратов для лечения лекарственно-устойчивого туберкулеза через призму экспериментальных исследований

The objective: to evaluate comparative neurotoxicity of combinations of anti-tuberculosis and antimicrobial drugs with different and similar toxic potentials assessing behavioral changes in rats.Subjects and Methods: non-linear female rats divided in 3 groups were used in this study. For 14 days, the rats received a daily combinations of drugs: Group 1 – Mxf + Lzd + Cs + Pto, Group 2 – Mxf + Bdq + Cs + Z , and Group 3 – Bdq + Lzd + Cfz + Z. Neurotoxicity was assessed by changes in behavioral responses using Open Field Test. The number of crossed squares and racks was recorded which characterized horizontal and vertical activity, also peeping into burrows (exploratory activity), the number of groomings (washing and scratching) and physiological functions were registered.Results. In rats of Group 1 versus baseline parameters, we observed a significant limitation of horizontal motor activity and a sharp decrease (by 5 times) in exploratory activity, a 2.8-fold decrease in the number of groomings which indicated emotional suppression. In rats of Groups 2 and 3, the decrease in motor and exploratory activity was insignificant but there was a more pronounced emotional depression. The use of the Mxf + Lzd + Cs + Pto combination in which all drugs possessed a neurotoxic potential, led to diverse and profound changes in behavioral responses which indicated a pronounced neurotoxic effect.Цель исследования: оценить сравнительную нейротоксичность сочетаний противотуберкулезных и антимикробных препаратов с различными и сходными токсическими потенциалами по изменению поведенческих реакций у крыс.Материал и методы: исследования проведены на нелинейных крысах-самках, разделенных на 3 группы. В течение 14 дней ежедневно крысы получали комплекс препаратов: в 1-й группе ‒ Mxf + Lzd + Cs + Pto; во 2-й группе ‒ Mxf + Bdq + Cs + Z, в 3-й ‒ Bdq + Lzd + Cfz + Z. Нейротоксичность оценивали по изменению поведенческих реакций в тесте «Открытое поле». Фиксировали количество пересеченных квадратов и стоек, что характеризует горизонтальную и вертикальную активность, заглядываний в норки (исследовательская активность), количество грумингов (умываний, почесываний) и физиологические отправления.Результаты. У крыс 1-й группы по сравнению с исходными показателями наблюдали значительное ограничение горизонтальной двигательной активности и резкое снижение (в 5 раз) исследовательской активности, в 2,8 раза уменьшение количества грумингов, что свидетельствует об эмоциональном угнетении. У крыс 2-й и 3-й групп снижение двигательной и исследовательской активности было незначительным, но было более выраженное эмоциональное угнетение. Применение комбинации Mxf + Lzd + Cs + Pto, в которой все препараты имеют нейротоксический потенциал, привело к разнообразным и глубоким изменениям поведенческих реакций, что свидетельствует о выраженном нейротоксическом эффекте

SPECIFICS OF CONSCIOUS SELF-REGULATION IN SCHOOLCHILDREN WITH DIFFERENT PROFILES OF LEARNING

The study considers specificity of regulatory resources in the schoolchildren educated in various profiles, with different levels of academic achievements. The data analysis revealed the differences in indicators of conscious self-regulation between the four groups of schoolchildren, divided according their learning profiles (physical and mathematical, chemical and biological, linguistic, and humanitarian). Differences in the indicators of conscious self-regulation were also revealed within each of the four profiled groups between children with low and high scores obtained based on the unified state exam.Исследуется специфика в выраженности регуляторных ресурсов у школьников, обучающихся на различных профилях, при разном уровне их академических достижений. Выявлены различия по показателям осознанной саморегуляции у четырех групп школьников, разделенных в соответствии с четырьмя группами профилей (физико-математическим, химико-биологическим, лингвистическим и гуманитарным). Различия по показателям осознанной саморегуляции установлены внутри каждого из четырех профилей в группах с низкими и высокими баллами, полученными по итогам единого государственного экзамена.Исследование выполнено при финансовой поддержки РФФИ в рамках научного проекта № 20-013-00741