The Brief Mood Introspection Scale (BMIS)

The BMIS scale is an open-source mood scale consisting of 16 mood-adjectives to which a person responds (e.g., Are you happy ?). The scale can yield measures of overall pleasant-unpleasant mood, arousal-calm mood, and it also can be scored according to positive-tired and negative-calm mood

Application of Pad\'{e} interpolation to stationary state problems

If the small and large coupling behavior of a physical system can be computed perturbatively and expressed respectively as power series in a coupling parameter $g$ and $1/g$, a Pad\'{e} approximant embracing the two series can interpolate between these two limits and provide an accurate estimate of the system's behavior in the generally intractable intermediate coupling regime. The methodology and validity of this approach are illustrated by considering several stationary state problems in quantum mechanics.Comment: RevTeX4, 7 pages (including 7 tables); v4 typos correcte

CONTESTED GOVERNANCE AND LESSON DRAWING: A CRITICAL ASSESSMENT OF THE SOCIAL LICENSE MODEL IN CANADA’S AGRI-FOOD SECTOR (1998-2018)

Focusing on Canada’s agri-food sector, this research offers a critical assessment of the social license model as a private self-governance regime. The study specifically seeks to understand the model’s role in the adoption and successful commercialization of biologically derived foods, products and innovation. Over the years, there have been several efforts to generate broad social acceptance of agricultural biotechnologies (agbiotech) because of the controversies they generate. Questions about acceptance and adoption of new technologies bring to the fore the concept of social license which has been adopted by many different sectors over the last two decades. Despite its widespread adoption, there remain significant gaps and variations in understanding, interpreting and implementing the model. One principal overarching question in this research is: if agbiotech acceptance is a major problem, is social license an effective solution? This study argues that social license will do one of two things in the pathway to agbiotech adoption: facilitate acceptance and successful commercialization or escalate rejection. This study theoretically unpacks the governance of agbiotech using Ostrom’s Institutional Analysis and Development (IAD) Framework. Through this framework the research finds that social license is, in effect, an attempt to bridge two contrasting agbiotech regulatory architectures: the scientific rationality regulatory approach, premised upon the use of scientific evidence to assess potential risks of new biotechnologies, and the social rationality regulatory approach which supports a broader socio-economic mandate. The qualitative empirical analysis for this dissertation draws on institutional and discourse analysis, three case studies of successful and unsuccessful agbiotech adoption and commercialization and 27 semi-structured interviews from various agri-food stakeholders across three Canadian provinces: Ontario, Alberta and Saskatchewan. This research finds that the most noticeable achievement of the social license model is its ability to bring social considerations into mainstream corporate discourse and decision-making and puts the focus on the need for communication and education in the agri-food sector. However, social license as a governance model in Canada’s agri-food sector has been unworkable for several reasons. The concept is basically more rhetorical than methodical, with little or no evidence of an effective or successful implementation in this sector. This is further compounded by the variations and gaps in the understanding of social license among the diverse stakeholders, contributing to a general lack of consensus as to what social license means in Canada. There is also a misalignment between the original intent of social license and the principal challenges of Canada’s agri-food sector, with the result that social license is acting more as a veto than a bridge. Some stakeholders are already changing the narrative from social license to public trust. The conceptual overlap and jurisdictional confusion between social license and corporate social responsibility makes social license more of a duplication of effort than a value addition and an incremental adjustment to other existing private self-governance regimes. Social license also fails to address the central issues in the overall governance and regulation of agbiotech: the minimization of risks and uncertainty. Elevating social license to a concept with veto power capable of supplanting government approval of agbiotech innovation is problematic for democracy, the rule of law and public policy and stifles innovation and development

The Evolution Of The European Legal System: The European Court Of Justice\u27s Role In The Harmonization Of Laws

After the dust settled from World War II, Winston Churchill declared the need for Europe to integrate economically and politically

Mechanistic studies on DNA damage by minor groove binding copper–phenanthroline conjugates

Copper–phenanthroline complexes oxidatively damage and cleave nucleic acids. Copper bis-phenanthroline and copper complexes of mono- and bis-phenanthroline conjugates are used as research tools for studying nucleic acid structure and binding interactions. The mechanism of DNA oxidation and cleavage by these complexes was examined using two copper–phenanthroline conjugates of the sequence-specific binding molecule, distamycin. The complexes contained either one or two phenanthroline units that were bonded to the DNA-binding domain through a linker via the 3-position of the copper ligand. A duplex containing independently generated 2-deoxyribonolactone facilitated kinetic analysis of DNA cleavage. Oxidation rate constants were highly dependent upon the ligand environment but rate constants describing elimination of the alkali-labile 2-deoxyribonolactone intermediate were not. Rate constants describing DNA cleavage induced by each molecule were 11–54 times larger than the respective oxidation rate constants. The experiments indicate that DNA cleavage resulting from β-elimination of 2-deoxyribonolactone by copper–phenanthroline complexes is a general mechanism utilized by this family of molecules. In addition, the experiments confirm that DNA damage mediated by mono- and bis-phenanthroline copper complexes proceeds through distinct species, albeit with similar outcomes

Relationship of Proportion Independent Commissioners on Company Risk and Management Risk Committee as a Moderation

The objective of this paper is looking for correlation of both proportion independent commissioners and presence of a risk management committee (RMC) which influences company risk. Company risk, proxy in trade accounts receivable and inventories. Accounts receivable and inventories have a possibility of errors in valuation, which can increase financial reporting risk. The samples used manufacturing industries, various industrial sectors; automotive sub-sectors ten numbers that listing on IDX or Indonesia Stock Exchange based on the outcome of purposive sampling for 3 years of research namely 2015-2017. The data taken from financial annual report and logistic regression analysis. The outcome of the logistic regression describes that portion of independent commissioners are significantly definite related to company risk. RMC variable is proven to strengthen the influence of relation both of proportions independent commissioners on company risk. Keywords: Risk Management, Independent Commissioners, and Automotive Industry DOI: 10.7176/EJBM/11-21-10 Publication date:July 31st 201

Comparative Analysis of Linker Histone H1, MeCP2, and HMGD1 on Nucleosome Stability and Target Site Accessibility

Chromatin architectural proteins (CAPs) bind the entry/exit DNA of nucleosomes and linker DNA to form higher order chromatin structures with distinct transcriptional outcomes. How CAPs mediate nucleosome dynamics is not well understood. We hypothesize that CAPs regulate DNA target site accessibility through alteration of the rate of spontaneous dissociation of DNA from nucleosomes. We investigated the effects of histone H1, high mobility group D1 (HMGD1), and methyl CpG binding protein 2 (MeCP2), on the biophysical properties of nucleosomes and chromatin. We show that MeCP2, like the repressive histone H1, traps the nucleosome in a more compact mononucleosome structure. Furthermore, histone H1 and MeCP2 hinder model transcription factor Gal4 from binding to its cognate DNA site within the nucleosomal DNA. These results demonstrate that MeCP2 behaves like a repressor even in the absence of methylation. Additionally, MeCP2 behaves similarly to histone H1 and HMGD1 in creating a higher-order chromatin structure, which is susceptible to chromatin remodeling by ISWI. Overall, we show that CAP binding results in unique changes to nucleosome structure and dynamics