Analysis of small ruminants’ pastoral management practices as risk factors of peste des petits ruminants (PPR) spread in Turkana District, Kenya

Peste des petits ruminants (PPR) is an emerging viral disease spreading throughout Kenya and East Africa causing major losses in the small stock. This study is an attempt to evaluate small stock management practices in Turkana pastoral system, Kenya as predictors of PPR outbreaks. Information on the social practices and the occurrence of PPR outbreaks was obtained by participatory techniques. The small stock management practices, evaluated as factors, in a previous study were simultaneously analyzed with seasons and administrative divisions as the independent risk factors for the presence or absence of PPR outbreaks in 142 Adakars (villages) as the dependent variable. Analyses were carried out for the years 2009 and 2010 combined as one data set and considered as longitudinal repeated data. In the analyses, the presence or absence of PPR outbreaks was the dependent variable. Data were further analyzed separately disaggregated by season where the presence or absence of PPR outbreaks in a season was considered as the dependent variable. All analyses utilized multivariable logistical regression analyses. In the longitudinal analysis, season was the only significant factor associated with PPR outbreak. Disaggregating the data by season revealed that certain seasonal-specific livestock management activities increased the risk of reporting PPR outbreaks: (1) sharing water sources leading to social aggregation of young stock in one point (Factor 3) (odds ratio (OR) = 2.0) in season 2 (wet season) of 2009; (2) sick dams left to nurse their young kids/lambs (Factor 7) (OR=1.62) in the same season in 2010. The finding of diverse risk factors in the same seasons across years suggests temporal heterogeneity in the distribution and occurrence of the determinants of PPR in the Turkana ecosystem. The study discusses the implications of these findings on disease control

INFLUENCE OF TAX COMPLIANCE COST ON HOSTEL OWNERS’ COMPLIANCE TO RENTAL INCOME TAX IN LAIKIPIA WEST SUB COUNTY, KENYA

The Government of Kenya through the Finance Act 2015 introduced a simplified rental income tax. This is a monthly tax payable by a resident person for rental income earned from use or occupation of residential property. Upon the gazettement of the Income Tax (Residential Rental Income Tax) Regulations, 2016, the Kenya Revenue Authority embarked on an aggressive campaign to enlist landlords into the Monthly Rental Income Tax regime. However, the Economic Survey 2021 showed that the country’s revenue collecting agency KRA was not able to meet revenue targets as set by the National Treasury. Comparison of National Government Budget Estimates with Actual Out – turns for the fiscal years 2017/2018 and 2018/2019 showed that KRA missed the Budgeted Ordinary Revenue targets by Kshs.128.7 Billion and Kshs.90.1 Billion respectively. Property taxes including rental income tax are part of the ordinary revenue collected by the tax authority. The objective of the study was to investigate the influence of tax compliance cost on hostel owners’ compliance to the monthly rental income tax in Laikipia West Sub County. Quantitative data was collected using questionnaires. A census of the entire population of hostels was used to collect the required data. The collected data was analysed using the Statistical Package for Social Sciences (SPSS). The study established that an increase in tax compliance cost discourages compliance behavior since taxpayers tend to evade the costs either by under-declaring their monthly rental incomes or not declaring any income at all. The study recommends that KRA should scale up the tax payer education and awareness programs to ensure that more landlords are trained on how to file their own returns without having to use tax agents who make the process costly leading to non-compliance.JEL: H25, H26  Article visualizations

Local Participation in Community Forest Associations: A Case Study of Sururu and Eburu Forests, Kenya

Participation of local communities in the management and utilization of state-owned forest resources has become widely recognized in contrast to centralised forms of forest governance. This paper examined the extent of inclusiveness and household participation in community forest associations (CFAs) adjacent to Sururu and Eburu forests in Kenya. The probit model was used to assess the socio-economic factors determining participation in the CFAs. The study established that gender (P<0.05), group membership (P<0.0001), ownership of tree nursery (P<0.0001), wealth status (P<0.0001), percentage share of wage income (P<0.05), and farm size allocated to trees (P<0.05) significantly influenced CFA participation. However, because of high opportunity participation costs some poor (68%) and rich (65%) households did not participate in CFA activities. Since households participated in CFAs to derive livelihood gains, unclear participation benefits offered little incentive to get involved. Thus participation in CFA activities remained low. Therefore, Kenya Forest Service should review participation guidelines to enable effective CFA input in decision making on forest issues. Keywords: Community; inclusiveness; household; participation; user groups; participatory forest managemen

The use of a P. falciparum specific coiled-coil domain to construct a self-assembling protein nanoparticle vaccine to prevent malaria.

The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development of a malaria vaccine is to target the asexual blood stage that results in clinical symptoms. Most attempts have failed. New antigens such as P27A and P27 have emerged as potential new vaccine candidates. Multiple studies have demonstrated that antigens are more immunogenic and are better correlated with protection when presented on particulate delivery systems. One such particulate delivery system is the self-assembling protein nanoparticle (SAPN) that relies on coiled-coil domains of proteins to form stable nanoparticles. In the past we have used de novo designed amino acid domains to drive the formation of the coiled-coil scaffolds which present the antigenic epitopes on the particle surface. Here we use naturally occurring domains found in the tex1 protein to form the coiled-coil scaffolding of the nanoparticle. Thus, by engineering P27A and a new extended form of the coiled-coil domain P27 onto the N and C terminus of the SAPN protein monomer we have developed a particulate delivery system that effectively displays both antigens on a single particle that uses malaria tex1 sequences to form the nanoparticle scaffold. These particles are immunogenic in a murine model and induce immune responses similar to the ones observed in seropositive individuals in malaria endemic regions. We demonstrate that our P27/P27A-SAPNs induce an immune response akin to the one in seropositive individuals in Burkina Faso. Since P27 is highly conserved among different Plasmodium species, these novel SAPNs may even provide cross-protection between Plasmodium falciparum and Plasmodium vivax the two major human malaria pathogens. As the SAPNs are also easy to manufacture and store they can be delivered to the population in need without complication thus providing a low cost malaria vaccine

Organizational Customers’ Retention Strategies on Customer Satisfaction: Case of Equity Bank Thika Branch, Kenya

The study set to examine evaluate customers’ retention strategies on customer satisfaction in the banking sector in Kenya case of Equity bank Thika branch, Kenya. Despite their central role in the economy, banks are faced with intense competition as a result of many similar products offered in the market, fast changing technological advancements and demanding customers. These challenges have rendered most traditional forms of competitive advantage like cost management, technology, product features and robust marketing strategies ineffective. Due to this, most banks have resorted to customers’ retention. Specifically the study investigated how customers’ demographic factors (age, gender, income and level of formal education), service quality and corporate image affect customers’ retention in the banking industry in Kenya. Data for this study was collected from 100 customers of Equity bank, Thika branch who were selected through multistage sampling technique using a questionnaire. The quantitative data was analyzed using SPSS. Data was analyzed using both the descriptive and analytical techniques. The study result found that the quality of services offered by the bank has a great effect on customers’ retention. However, customers’ demographic factors like age, gender, level of formal education and marital status had no influence on customers’ retention. Further, the study found that the bank stability, reliability and involvement in community work will influence customers’ retention. This study therefore recommended that banks should strive to ensure good quality service so that they ensure high customer retention. This can be achieved by improving their opening hours and closing hours, speed of service, and degree of responsiveness to enquires, time taken to get service and good communication with the bank staff. Further, banks should market themselves but in their marketing they should emphasize their uniqueness especially on their services and products offered. Key words: Customer retention, Quality Service and Corporate imag

Men who have sex with men sensitivity training reduces homoprejudice and increases knowledge among Kenyan healthcare providers in coastal Kenya

Introduction: Healthcare workers (HCWs) in Africa typically receive little or no training in the healthcare needs of men who have sex with men (MSM), limiting the effectiveness and reach of population‐based HIV control measures among this group. We assessed the effect of a web‐based, self‐directed sensitivity training on MSM for HCWs (www.marps‐africa.org), combined with facilitated group discussions on knowledge and homophobic attitudes among HCWs in four districts of coastal Kenya. Methods: We trained four district “AIDS coordinators” to provide a two‐day training to local HCWs working at antiretroviral therapy‐providing facilities in coastal Kenya. Self‐directed learning supported by group discussions focused on MSM sexual risk practices, HIV prevention and healthcare needs. Knowledge was assessed prior to training, immediately after training and three months after training. The Homophobia Scale assessed homophobic attitudes and was measured before and three months after training. Results: Seventy‐four HCWs (68% female; 74% clinical officers or nurses; 84% working in government facilities) from 49 health facilities were trained, of whom 71 (96%) completed all measures. At baseline, few HCWs reported any prior training on MSM anal sexual practices, and most HCWs had limited knowledge of MSM sexual health needs. Homophobic attitudes were most pronounced among HCWs who were male, under 30 years of age, and working in clinical roles or government facilities. Three months after training, more HCWs had adequate knowledge compared to baseline (49% vs. 13%, McNemar's test p<0.001); this was most pronounced in those with clinical or administrative roles and in those from governmental health providers. Compared to baseline, homophobic attitudes had decreased significantly three months after training, particularly among HCWs with high homophobia scores at baseline, and there was some evidence of correlation between improvements in knowledge and reduction in homophobic sentiment. Conclusions: Scaling up MSM sensitivity training for African HCWs is likely to be a timely, effective and practical means to improve relevant sexual health knowledge and reduce personal homophobic sentiment among HCWs involved in HIV prevention, testing and care in sub‐Saharan Africa

Lipoprotein(a) and vascular redox state in patients with advanced coronary atherosclerosis

Background: Lipoprotein(a) (Lp(a)) is associated with cardiovascular disease, but neither the causal nature nor the underlying mechanisms are fully documented. This study investigated whether Lp(a) triggers atherogenesis by dysregulating vascular redoxsensitive inflammatory state.Methods: Plasma Lp(a) was measured in 1027 patients with advanced coronary artery disease (CAD) undergoing cardiac surgery. These patients were genotyped and a modified genetic risk score (LPA GRS) determining Lp(a) levels was generated. RNAsequencing and vascular superoxide (O2 .-) measurements were performed in internal mammary arteries (IMA), and the contribution of NADPH oxidases and uncoupled endothelial nitric oxide synthase (eNOS) determined. The median follow-up was 5.07 years.Results: Increased plasma Lp(a) (p=0.03) and LPA GRS (p=0.01), were associated with elevated arterial O2 .- in the overall patient population, an effect that was driven by non-diabetics. This effect was primarily due to eNOS uncoupling via reduced vascular tetrahydrobiopterin bioavailability. There was no significant impact of Lp(a) variability on vascular NADPH oxidase-derived O2 .- (p=0.13). RNA-sequencing of arterial tissue revealed dysregulation of nitrosative and inflammatory signaling in high Lp(a) patients, although there was no association with systemic biomarkers of inflammation (i.e. hsCRP) (p=0.82) or oxidative stress (i.e. malondialdehyde) (p=0.61). Finally, both LPA GRS (HR[95% CI]=3.615[1.044-12.515], p=0.043) and high plasma Lp(a) (HR[95% CI]=3.286 [1.003-10.767], p=0.049) were associated with elevated risk for cardiac mortality. This association was vascular O2 .--dependent, implying that redox-sensitive inflammatory signaling may be a link between Lp(a) and cardiovascular risk. All above associations were independent from plasma ApoB.Conclusions: This study demonstrates for the first time that a genetically determined increase in plasma Lp(a) results in dysregulated vascular redox/nitrosative signaling in patients with atherosclerosis