Analgesic and anti-inflammatory properties of Argyreia argentea methanol extract in animal model

AbstractAnalgesic effect of Argyreia argentea methanol extract was assessed by acetic acid and formalin induced pain in Swiss albino mice. The extract at doses of 1.0, 1.5 and 2.0 g/kg produced an inhibition of 12.66, 16.04 & 23.60% in acetic acid induced pain and 19.3, 24.5 & 31.0% in formalin induced pain. The anti-inflammatory activity of the same extract was estimated volumetrically by measuring the mean increase in hind paw volume of carrageenan-induced Wistar albino rat with plethysmometer. Oral administration of the extract at doses of 1.0, 1.5 and 2.0 g/kg showed a time-dependent (1st, 2nd, 3rd and 4th hour) response in reduction of inflammation where the highest inhibition 25.0, 36.36 and 44.0%, were recorded at the 4th hour of treatment. Diclofenac sodium (40 mg/kg) has been administrated as a positive control in the inhibition of acetic acid and formalin induced pain as well as in carrageenan-induced paw edema. The results demonstrate that the extract could be a new and potential source of anti-inflammatory and analgesic drug

CFD SIMULATION OF SCRAMJET INLET

For information such as a scramjet engine, the first definition of a ramjet engine, such as a scramjet engine, is a direct line of a plywood package. Ramjet engines are not part of the engine, but they work with acne, which slows the air at an accelerating rate, increases heat and intensity, and stimulates air control. Oil. Finally, the noise that causes pride in the speed of the video causes it to be pressed. Because of the evacuation of the free population, the heat and high level of fire flow "higher than the free flow." In Mach, located in Mach 6, these plugins do not work to reduce video streams. In this study, the scramjet engine usually starts with the development of a private health unit. 05:00. To find them in these fastest times, we used boats up to 3.00-4.00 from Mach, and from there we took the jet plane and started jumping to run the scramjet engine. If we expand the scramjet engine, the Mach engine will be 3.0.5.0.7.0 and 9.0. We can use the power supply, which means ramjet mechanism and reduces the weight and difficulty. The Scramjet engine project used in this project only aims at insurance plans for the implementation and verification of CFD floods. Use of component includes study on

Numerical solution of bio-nano-convection transport from a horizontal plate with blowing and multiple slip effects

In this paper, a new bio-nano-transport model is presented. The effects of first and second order velocity slips, thermal slip, mass slip, and gyro-tactic (torque-responsive) microorganism slip of bioconvectivenanofluid flow from amoving plate under blowing phenomenon are numerically examined. The flow model is expressed by partial differential equations which areconverted to a similar boundary value problem bysimilarity transformations. The boundary value problem is converted to a system of nonlinear equationswhich are then solved by a Matlab nonlinear equation solver fsolveintegrated with a Matlab ODEsolverode15s. The effects of selected control parameters (first order slip, second order slip, thermal slip, microorganism slip, blowing, nanofluid parameters) on the non-dimensional velocity, temperature, nanoparticle volume fraction, density ofmotile micro-organism, skin friction coefficient, heat transfer rate, mass flux of nanoparticles andmass fluxof microorganismsare analyzed. Our analysis reveals that a higher blowing parameter enhances micro-organism propulsion, flow velocityand nano-particle concentration, and increases the associated boundary layerthicknesses. A higher wall slip parameter enhances mass transfer and accelerates the flow. The MATLAB computations have been rigorously validated with the second-order accurate finite difference Nakamura tri-diagonal method.The current study is relevant to microbial fuel cell technologies which combine nanofluid transport, bioconvection phenomena and furthermore finds applications in nano-biomaterials sheetprocessing systems

1980s–2010s: the world’s largest mangrove ecosystem is becoming homogenous

Knowledge gaps in spatiotemporal changes in mangrove diversity and composition have obstructed mangrove conservation programs across the tropics, but particularly in the Sundarbans (10,017 km2), the world's largest remaining natural mangrove ecosystem. Using mangrove tree data collected from Earth's largest permanent sample plot network at four historical time points (1986, 1994, 1999 and 2014), this study establishes spatially explicit baseline biodiversity information for the Sundarbans. We determined the spatial and temporal differences in alpha, beta, and gamma diversity in three ecological zones (hypo-, meso-, and hypersaline) and also uncovered changes in the mangroves' overall geographic range and abundances therein. Spatially, the hyposaline mangrove communities were the most diverse and heterogeneous in species composition while the hypersaline communities were the least diverse and most homogeneous at all historical time points. Since 1986, we detect an increasing trend of compositional homogeneity (between-site similarity in species composition) and a significant spatial contraction of distinct and diverse areas over the entire ecosystem. Temporally, the western and southern hypersaline communities have undergone radical shifts in species composition due to population increase and range expansion of the native invasive species Ceriops decandra and local extinction or range contraction of specialists including the globally endangered Heritiera fomes. The surviving biodiversity hotspots are distributed outside the legislated protected area network. In addition to suggesting the immediate coverage of these hotspots under protected area management, our novel biodiversity insights and spatial maps can form the basis for spatial conservation planning, biodiversity monitoring and protection initiatives for the Sundarbans

3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery

3D printed microneedle arrays were fabricated using a biocompatible resin through stereolithography (SLA) for transdermal insulin delivery. Microneedles were built by polymerising consecutive layers of a photopolymeric resin. Thin layers of insulin and sugar alcohol or disaccharide carriers were formed on the needle surface by inkjet printing. The optimization of the printing process resulted in superior skin penetration capacity of the 3D printed microneedles compared to metal arrays with minimum applied forces varying within the range of 2 to 5 N. Micro-CT analysis showed strong adhesion of the coated films on the microneedle surface even after penetration to the skin. In vivo animal trials revealed fast insulin action with excellent hypoglycaemia control and lower glucose levels achieved within 60 min, combined with steady state plasma glucose over 4 h compared to subcutaneous injections

Social networking site use, personality, user habit, and subjective wellbeing: a Kazakhstani pilot study

Considering the prevalence and increased use of online social networking sites (SNSs), the present study investigated the association between visiting SNSs and users' subjective wellbeing. Data were collected from 251 participants and were analyzed using partial least square-based structural equation modeling. The findings showed that there was no significant direct influence of SNS use on users' subjective wellbeing. Additionally, the study found a significant mediating influence of passion on the association between SNS visits and subjective wellbeing. Moreover, the study did not find any significant negative mediating impact of obsession with SNS visits and association with subjective wellbeing. Among various personality traits, openness to experience had a positive moderating impact and neuroticism had a negative moderating impact on the association between SNS visits and subjective wellbeing among SNS users. The study provides implications for managers and parents regarding improved SNS use and increased subjective wellbeing

Psychosocial health of school-going adolescents during the COVID-19 pandemic: Findings from a nationwide survey in Bangladesh

From PLOS via Jisc Publications RouterHistory: received 2022-03-11, collection 2023, accepted 2023-03-08, epub 2023-03-27Acknowledgements: The authors would like to express the most profound gratitude to the authorities, teachers, parents, and students under the Konnect platform of a2i who contributed in the study. icddr,b is grateful to the governments of Bangladesh, Canada, Sweden and the UK for providing unrestricted support.Publication status: PublishedDaniel Reidpath - ORCID: 0000-0002-8796-0420 https://orcid.org/0000-0002-8796-0420Background: Common psychosocial health problems (PHPs) have become more prevalent among adolescents globally during the COVID-19 pandemic. However, the psychosocial health of school-going adolescents has remained unexplored in Bangladesh due to limited research during the pandemic. The present study aimed to estimate the prevalence of PHPs (i.e., depression and anxiety) and assess associated lifestyle and behavioral factors among school-going adolescents in Bangladesh during the COVID-19 pandemic. Methods: A nationwide cross-sectional survey was conducted among 3,571 school-going adolescents (male: 57.4%, mean age: 14.9±1.8 years; age range: 10–19 years) covering all divisions, including 63 districts in Bangladesh. A semi-structured e-questionnaire, including informed consent and questions related to socio-demographics, lifestyle, academics, pandemic and PHPs, was used to collect data between May and July 2021. Results: The prevalence of moderate to severe depression and anxiety were 37.3% and 21.7%, respectively, ranging from 24.7% in the Sylhet Division to 47.5% in the Rajshahi Division for depression, and from 13.4% in the Sylhet Division to 30.3% in the Rajshahi Division for anxiety. Depression and anxiety were associated with older age, reports of poor teacher cooperation in online classes, worries due to academic delays, parental comparison of academic performance with other classmates, difficulties coping with quarantine situations, changes in eating habits, weight gain, physical inactivity and having experienced cyberbullying. Moreover, being female was associated with higher odds of depression. Conclusions: Adolescent psychosocial problems represent a public health problem. The findings suggest a need for generating improved empirically supported school-based psychosocial support programs involving parents and teachers to ensure the well-being of adolescents in Bangladesh. School-based prevention of psychosocial problems that promote environmental and policy changes related to lifestyle practices and active living should be developed, tested, and implemented.pubpu

Carbon Fibers Coated with Ternary Ni-Co-Se Alloy Particles as Low-cost Counter Electrode for Flexible Dye Sensitized Solar Cell

Compared to flat devices based on rigid substrates, cable-shaped dye-sensitized solar cells hold advantages of smaller size, light weight, facile fabrication, flexibility, and low cost, thus a promising direction for applications such as wearable electronic devices. However, most reported fiber-shaped dye-sensitized solar cells use Pt wires as counter electrodes, which are high in cost. Herein, a flexible Pt-free counter electrode is fabricated via depositing ternary nickel cobalt selenide (Ni–Co–Se) particles on the surface of carbon fibers. Scanning electron microscopy and X-ray diffraction are used to characterize the counter electrode and alloy material. Results from bare and modified carbon fiber counter electrodes reveal that Ni–Co–Se alloy particles greatly enhance electrocatalytic activity, leading to significant improvement in power conversion efficiency, which is comparable with devices using carbon fiber coated with Pt as the counter electrode. The performance increase may be attributed to the improved catalytic property of CoSe2 due to its higher composition ratio and larger crystallite size. Bending and multiple irradiation cycling tests are also performed to show the superior flexibility and durability of the novel device

A Model of Technology Transfer in Japan's Rapid Economic Growth Period

Why did the Japanese economy stagnate before World War II, how did it achieve rapid economic growth after the war, and why did it stagnate again after the 1970s? To answer these questions, I developed a two-country trade model with technology transfer, where firms in a developed country (the U.S.) transfer technology to the competitors in a developing country (Japan) if it is profitable to do so and where the technology transfer is the engine of economic growth. In this model, among multiple equilibria, the equilibrium with low labor cost in Japan was chosen during the rapid growth period. Then, the firms in the developed country transferred technology to the firms in the developing country, resulting in rapid growth. However, during the other periods, the equilibrium with high labor cost in Japan was chosen, which caused stagnation. The model is quantitatively consistent with the per capita GDP relative to the U.S., the purchasing power parity-exchange rate ratio, and to some degree, the swings in labor share of postwar Japan