Preliminary pharmacological investigation of the ischuretic property and safety of a hydro-ethanolic extract of Amaranthus spinosis (Fam: Amaranthaceae)

Background: Ischuria is a health and social problem, having a negative impact on sufferers. This study therefore was a preliminary investigation of the ischuretic property and safety for use of a hydro-ethanolic extract of Amaranthus spinosus used traditionally in managing ischuria.Methods: Phytochemical screening, thin layer chromatography and high performance liquid chromatography were performed on the extract to establish fingerprints for identification. Acetylcholine, Nicotine, and the extract were applied to an isolated rat urinary bladder to ascertain contractile response. The possible receptor site(s) of action was also investigated using isolated rabbit jejunum, and guinea-pig ileum preparations. In-house observation, hematological analysis, and liver and kidney function tests were performed on Sprague-Dawley rats, in acute and sub-acute toxicity studies.Results: The extract had contractile effects on the rat urinary bladder (similar to acetylcholine and nicotine) and rabbit jejunum. Its contractile effect of the guinea-pig ileum was significantly inhibited by hexamethonium (77.50 ± 8.50 %; P ≤ 0.001) and to a lesser extent by mepyramine (49.2 ± 6.80 %; P ≤ 0.001) and Atropine (22.45 ± 5.22 %; P ≤ 0.01). The extract (80-800 mg kg-1) was not lethal and a 160 and 240 mg kg-1 dose had no adverse effect on blood, liver, kidney metabolic function.Conclusions: The hydro-ethanolic extract of Amaranthus spinosus has ischuretic activity possibly mediated via nicotinic, histaminic and muscarinic receptor stimulation and is safety to use in ischuria

Neutralization and Attenuation of Metal Species in Acid Mine Drainage and Mine Leachates Using Magnesite: a Batch Experimental Approach

Abstract This paper evaluates the potential application of amorphous magnesite for remediation of Acid Mine Drainage (AMD). Magnesite was mixed with simulated AMD at specific S/L ratios and agitated in an orbital shaker and its capacity to remove metals and neutralize the acidity assessed over time. XRF analysis showed that magnesite contains MgO (88.54 %) as the major element. XRD revealed that magnesite is amorphous and contains periclase as major mineral phase. Results indicate that contact of AMD with magnesite leads to an increase in pH (pH≥10), and a reduction in EC, TDS and metal concentration to below DWAF guidelines. PHREEQC geochemical modeling predicted precipitation of Al, Fe, Mn, Mg bearing mineral phases could be responsible for attenuation of most metal species. However a high proportion of alkali and alkaline earth metals remained in the treated water which might require post treatment polishing

Phase-Locked Spatial Domains and Bloch Domain Walls in Type-II Optical Parametric Oscillators

We study the role of transverse spatial degrees of freedom in the dynamics of signal-idler phase locked states in type-II Optical Parametric Oscillators. Phase locking stems from signal-idler polarization coupling which arises if the cavity birefringence and/or dichroism is not matched to the nonlinear crystal birefringence. Spontaneous Bloch domain wall formation is theoretically predicted and numerically studied. Bloch walls connect, by means of a polarization transformation, homogeneous regions of self-phase locked solutions. The parameter range for their existence is analytically found. The polarization properties and the dynamics of walls in one- and two transverse spatial dimensions is explained. Transition from Bloch to Ising walls is characterized, the control parameter being the linear coupling strength. Wall dynamics governs spatiotemporal dynamical states of the system, which include transient curvature driven domain growth, persistent dynamics dominated by spiraling defects for Bloch walls, and labyrinthine pattern formation for Ising walls.Comment: 27 pages, 16 figure

The Energy-Scaling Approach to Phase-Ordering Growth Laws

We present a simple, unified approach to determining the growth law for the characteristic length scale, $L(t)$, in the phase ordering kinetics of a system quenched from a disordered phase to within an ordered phase. This approach, based on a scaling assumption for pair correlations, determines $L(t)$ self-consistently for purely dissipative dynamics by computing the time-dependence of the energy in two ways. We derive growth laws for conserved and non-conserved $O(n)$ models, including two-dimensional XY models and systems with textures. We demonstrate that the growth laws for other systems, such as liquid-crystals and Potts models, are determined by the type of topological defect in the order parameter field that dominates the energy. We also obtain generalized Porod laws for systems with topological textures.Comment: LATeX 18 pages (REVTeX macros), one postscript figure appended, REVISED --- rearranged and clarified, new paragraph on naive dimensional analysis at end of section I

Leachate Characterization and Assessment of Unsaturated Zone Pollution near Municipal Solid Waste Landfill Site at Oblogo, Accra-Ghana

Abstract: Leachate and unsaturated zone water samples were collected from landfill-site and its adjacent area at Oblogo, Accra-Ghana to study the possible impact of leachate percolation on unsaturated zone water quality. Concentration of various physico-chemical parameters including heavy metal (Cd, Cr, Cu, Fe, Mn, As, V, and Zn) were determined in unsaturated zone water and leachate samples. The moderately high concentrations of ClG, NO 3 G, SO 4 2 G, Fe, Zn, Cd, Cr, Cu, Fe, Mn, and BOD in unsaturated zone water, likely indicate that water quality in the unsaturated zone is being significantly affected by leachate percolation. This suggests that leachate percolation is having an impact the unsaturated zone water which indicates the originality of the groundwater in the area is threatened

Must Land Reform Benefit the Victims of Colonialism?

Appealing to African values associated with ubuntu such as communion and reconciliation, elsewhere I have argued that they require compensating those who have been wronged in ways that are likely to improve their lives. In the context of land reform, I further contended that this principle probably entails not transferring unjustly acquired land en masse and immediately to dispossessed populations since doing so would foreseeably lead to such things as capital flight and food shortages, which would harm them and the broader society. Oritsegbubemi Anthony Oyowe has recently argued against my claim that land reform should be enacted in a way expected to benefit victims of colonialism while not greatly burdening innocent third parties, instead supporting the return of land to its rightful owners regardless of how the manner in which it were done would affect people’s quality of life. Here I expound Oyowe’s argumentation and respond to it in defence of my initial position, appealing to examples from southern Africa to illustrate

African Communitarianism and Difference

There has been the recurrent suspicion that community, harmony, cohesion, and similar relational goods as understood in the African ethical tradition threaten to occlude difference. Often, it has been Western defenders of liberty who have raised the concern that these characteristically sub-Saharan values fail to account adequately for individuality, although some contemporary African thinkers have expressed the same concern. In this chapter, I provide a certain understanding of the sub-Saharan value of communal relationship and demonstrate that it entails a substantial allowance for difference. I aim to show that African thinkers need not appeal to, say, characteristically Euro-American values of authenticity or autonomy to make sense of why individuals should not be pressured to conform to a group’s norms regarding sex and gender. A key illustration involves homosexuality

The Household Water Insecurity Experiences (HWISE) Scale: comparison scores from 27 sites in 22 countries

Abstract Household survey data from 27 sites in 22 countries were collected in 2017–2018 in order to construct and validate a cross-cultural household-level water insecurity scale. The resultant Household Water Insecurity Experiences (HWISE) scale presents a useful tool for monitoring and evaluating water interventions as a complement to traditional metrics used by the development community. It can also help track progress toward achievement of Sustainable Development Goal 6 ‘clean water and sanitation for all’. We present HWISE scale scores from 27 sites as comparative data for future studies using the HWISE scale in low- and middle-income contexts. Site-level mean scores for HWISE-12 (scored 0–36) ranged from 1.64 (SD 4.22) in Pune, India, to 20.90 (7.50) in Cartagena, Colombia, while site-level mean scores for HWISE-4 (scored 0–12) ranged from 0.51 (1.50) in Pune, India, to 8.21 (2.55) in Punjab, Pakistan. Scores tended to be higher in the dry season as expected. Data from this first implementation of the HWISE scale demonstrate the diversity of water insecurity within and across communities and can help to situate findings from future applications of this tool