152 research outputs found
On inclusive education of students with autism spectrum disorder
This article analyzes the principles of inclusive education of students with Autism Spectrum Disorder. The commitment to help such students in the attainment of effective communication skills and social skills in the general classroom, social adaptation, and an assistance with the acquisition daily and community living skills characterize approaches to educating students with autismΠ ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠΈΠ½ΡΠΈΠΏΡ ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΠΌΠ΅ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠ°ΡΠΈΡ
ΡΡ, ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ
ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ Π°ΡΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ°. ΠΡΠΈΠ½ΡΠΈΠΏΡ ΠΈΠ½ΠΊΠ»ΡΠ·ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΡΡΠ΅ΠΌΠ»Π΅Π½ΠΈΠ΅ ΠΏΠΎΠΌΠΎΡΡ ΡΠ°ΠΊΠΈΠΌ ΡΡΠ°ΡΠΈΠΌΡΡ Π² ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π½Π°Π²ΡΠΊΠΎΠ² ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ΅Π½ΠΈΡ, ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ
Π½Π°Π²ΡΠΊΠΎΠ² ΠΈ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ ΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΆΠΈΠ·Π½ΠΈ ΡΠ²Π»ΡΡΡΡΡ ΠΎΡΠ½ΠΎΠ²ΠΎΠΏΠΎΠ»Π°Π³Π°ΡΡΠΈΠΌΠΈ ΠΏΡΠΈΠ½ΡΠΈΠΏΠ°ΠΌΠΈ Π² ΠΎΠ±ΡΡΠ΅Π½ΠΈΠΈ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Ρ Π°ΡΡΠΈΠ·ΠΌΠΎΠΌ Π² Π‘Π¨
DEVELOPMENT OF MANAGEMENT OF REPRODUCTION OF FIXED ASSETS
The article is devoted to topical issues of development of management of reproduction of fixed assets. The authors emphasize an important role for the successful solution of important problems of development management of such forms of reproduction of fixed assets as the repair, reconstruction, modernization or upgrading in terms of implementation of innovation investment in the modern requirements of the domestic market economy
DEVELOPMENT OF MANAGEMENT OF REPRODUCTION OF FIXED ASSETS
The article is devoted to topical issues of development of management of reproduction of fixed assets. The authors emphasize an important role for the successful solution of important problems of development management of such forms of reproduction of fixed assets as the repair, reconstruction, modernization or upgrading in terms of implementation of innovation investment in the modern requirements of the domestic market economy
Presentations in Lectures to Prompt Innovations in Higher Education
Considering the rich experience of using multimedia presentations as a teaching tool in higher education, in order to introduce new approaches and develop a methodology, there is a need to identify the strengths and weaknesses of existing practices, in particular to identify the emotional attitude of university students to existing lectures and presentations in the educational process and determine relevant opportunities to improve the practice of using interactive and visual educational tools.The empirical basis of the study was the results of a survey of students of 2β4 undergraduate courses at the Moscow State Institute of International Relations (University) of the Russian Ministry of Foreign Affairs in the 2019β2020 academic year. The survey involved 404 respondents. To process the obtained data, we used the Google Forms and Microsoft Office Excel programs, general scientific methods (comparison, generalization), statistical analysis methods, as well as content analysis.The empirical study showed a high level of student satisfaction with the volume and effectiveness of multimedia presentations used in the educational process, and also confirmed the theoretical ideas about the advantages and limitations of linear form presentations that dominate in the educational environment. Critical remarks included design errors, oversaturation of visual material, activity out of sync, and flaws in speaker behavior. Among the new techniques for working with presentation materials, photographing slides was noted. An important observation was the studentsβ request for self-sufficient visual materials of lectures and access to them.Prospects and opportunities for transforming familiar lectures and the learning environment as a whole were identified taking into account the existing experience of presentations at the university; ways of solving the problems with studentsβ perception and acquisition of material are proposed and specific recommendations are given for organizing a wide range of classes with visual and interactive components, today these are, first of all, remote online courses (MOOC, e-learning) and new forms of organization classroom activities (βflipped classroomβ)
Depression, cognitive dysfunction and other factors associated with 5-year overall mortality in type 2 diabetes mellitus: a pilot prospective observational study
BACKGROUND: Psychological predictors of overall mortality in the Russian population of Type 2 diabetic patients and their impact compared to biological risk factors have not been studied.AIM. To identify clinical, laboratory and psychological factors independently associated with the 5-year overall mortality in Type 2 diabetic patients in the Moscow region.MATERIALS AND METHODS: This open label observational prospective study included 178 consecutive type 2 diabetic patients (women 145, men 33, age range 37 to 82 years, duration of diabetes 0,5 to 30 years). At baseline, in addition to the standard clinical, laboratory and instrumental work-up, all patients were assessed for depression, cognitive dysfunction and diabetes-related quality of life. No study-related intervention was performed; all patients were followed up and treated by their local physicians. After 5 years, we assessed the patientsβ vital status (alive or dead). Multiple logistic regression was used to identify baseline patientsβ characteristics, which were significantly and independently associated with 5-year overall mortality. Taking into account the exploratory type of multiple regression, the results were considered significant at Ξ±<0.1.RESULTS: At 5 years, 150 (84%) patients were alive and 15 (8,4%) were dead; no information could be obtained for the rest 13 (7,3%) patients. The analysis of 165 patients with the verified outcome, independent and significant associations with the death outcome were found for male gender (odds ratio [OR] 6,36 [95%CI 0,91β44.40]; p=0.06), age (OR 2.06 [1.30β3.27]; p<0.002), chronic heart failure (CHF) (OR 2.78 [1.25β6.2]; Ρ=0.012), Hamilton depression scale score (OR 1,18 [1.03β1.34]; Ρ=0.016), cognitive dysfunction score (Roschina scale) (OR 1.20 [1.05β1.35]; Ρ=0.006), and age β body mass index interaction (OR 0,98 [0,97β0,997]; Ρ = 0,013). The predicted probability of death within the next 5 years in men and women was 22,9% and 6,7%, respectively. The highest score of cognitive dysfunction was associated with a 25% predicted probability of death and the lowest, with a 2% probability of death; predicted probabilities of death for the highest and lowest depression scores were 26% and 2%, respectively. The 5-year predicted probability of death in the patients without CHF was 6,7%, with CHF I NYHA functional class, 9,8%, II functional class 13,6%, III functional class 18,2%, and IV functional class 23,5%. All other baseline clinical, laboratory, demographic, psychological and socioeconomic variables were not significantly associated with the 5-year survival rate. The model was not verified on an external cohort.CONCLUSION: Cognitive dysfunction and depression have a significant negative impact on the 5-year mortality rate at much higher degree, than glycemic control, any diabetes-related complications and cardiovascular disorders, excluding CHF. The results obtained highlight the importance of the diagnosis and treatment of depression and cognitive dysfunction inΒ type 2 diabetes mellitus
ΠΡΠ΅Π½ΠΊΠ° ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½
The purpose of this paper is to develop a comprehensive approach to evaluating digitalization of interaction of the state and citizens in the sphere of providing state services. The objectives of the study include the analysis of current Russian and foreign approaches to assessing the digitalization of interaction between the state and citizens; development and testing of a composite indicator methodology for conducting such an assessment in the provision of public services. Materials and methods. When preparing the paper, the authors studied Russian and foreign theoretical and practical approaches to evaluating digitalization of interaction between the state and citizens. The approbation of the digitalization index of interaction between the state and citizens proposed in the article was carried out on the basis of data from a selective federal statistical observation of the Federal State Statistics Service on the use of information technologies, information and communication networks by the population, as well as the data from the Ministry of Economic Development of the Russian Federation. To achieve the objective, theoretical methods (comparative analysis, synthesis, and generalization), modelling, and correlation analysis were used. Results. Based on the analysis of foreign and Russian approaches, their advantages and limitations, the article substantiates the methodology for calculating the digitalization index of interaction between the state and citizens, taking into account the immediate results (the availability of state and municipal services in the electronic form), intermediate results (the demand for the electronic form of service provision) and the final results of digital transformation in the provision of public services (satisfaction of citizens with the quality of services provided in the electronic form), as well as the risks of digital interaction (the level of digital trust of citizens in the interaction with the state). Approbation of the digitalization index of interaction between the state and citizens in the regional context was carried out. To assess the applicability of the proposed index, the correlation dependence of its values and the values of the index components on the level of education of the population, employment, income and urbanization, as well as differences in the availability of information and communication technologies infrastructure was investigated. At the same time, the level of digitalization correlation of interaction between the state and citizens with social factors is higher than with infrastructural ones. This means that to solve the problem of digital inequality in Russian regions, it is not enough to provide universal access to the Internet; factors of human capital development also play an important role in promoting digital channels of interaction. Conclusion. Assessing the digitalization of interaction between the state and citizens requires taking into account various indicators that reflect the immediate, intermediate and final results of such an interaction, as well as the risks associated with the transition to βdigitβ. In terms of the provision of public services for such an assessment, it is advisable to use the digitalization index of interaction between the state and citizens. Further promising areas of research in the field of assessing the digitalization of interaction between the state and citizens are related to the study of the influence of citizensβ trust in government bodies on the level of digitalization of interaction between the state and citizens, as well as taking into account the interaction of citizens and the state within the framework of other types of state functions (development and implementation of state policy, regulation, control and supervisory activities). The implementation of these directions will require the expansion of the currently available information base.Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΡΡΠ°Π±ΠΎΡΠΊΠ° ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΊ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½ Π² ΡΡΠ΅ΡΠ΅ ΠΎΠΊΠ°Π·Π°Π½ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ»ΡΠ³. Π Π·Π°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²Ρ
ΠΎΠ΄ΠΈΡ Π°Π½Π°Π»ΠΈΠ· Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΡ
ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΡ
ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½; ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΈ Π°ΠΏΡΠΎΠ±Π°ΡΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π΄Π»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠ°ΠΊΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ Π² ΡΡΠ΅ΡΠ΅ ΠΎΠΊΠ°Π·Π°Π½ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ»ΡΠ³. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ ΡΡΠ°ΡΡΠΈ Π°Π²ΡΠΎΡΠ°ΠΌΠΈ ΠΈΠ·ΡΡΠ΅Π½Ρ ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΠ΅ ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΠ΅ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½. ΠΠΏΡΠΎΠ±Π°ΡΠΈΡ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ Π² ΡΡΠ°ΡΡΠ΅ ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π°Π½Π½ΡΡ
Π²ΡΠ±ΠΎΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π€Π΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ»ΡΠΆΠ±Ρ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΡΠ°ΡΠΈΡΡΠΈΠΊΠΈ ΠΏΠΎ Π²ΠΎΠΏΡΠΎΡΠ°ΠΌ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ ΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎ-ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅ΡΠ΅ΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄Π°Π½Π½ΡΡ
ΠΠΈΠ½ΠΈΡΡΠ΅ΡΡΡΠ²Π° ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ. ΠΠ»Ρ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΡΠ΅Π»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ (ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ·, ΡΠΈΠ½ΡΠ΅Π·, ΠΎΠ±ΠΎΠ±ΡΠ΅Π½ΠΈΠ΅), ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ·. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡ
ΠΎΠ΄Ρ ΠΈΠ· Π°Π½Π°Π»ΠΈΠ·Π° Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΠΈ ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ², ΠΈΡ
ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ² ΠΈ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΠΉ, Π² ΡΡΠ°ΡΡΠ΅ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ ΡΠ°ΡΡΠ΅ΡΠ° ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½, ΡΡΠΈΡΡΠ²Π°ΡΡΠ΅Π³ΠΎ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ (Π½Π°Π»ΠΈΡΠΈΠ΅ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈ ΠΌΡΠ½ΠΈΡΠΈΠΏΠ°Π»ΡΠ½ΡΡ
ΡΡΠ»ΡΠ³ Π² ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΌ Π²ΠΈΠ΄Π΅), ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ (Π²ΠΎΡΡΡΠ΅Π±ΠΎΠ²Π°Π½Π½ΠΎΡΡΡ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΡΠΎΡΠΌΡ ΠΎΠΊΠ°Π·Π°Π½ΠΈΡ ΡΡΠ»ΡΠ³) ΠΈ ΠΊΠΎΠ½Π΅ΡΠ½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΈΡΡΠΎΠ²ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π² ΡΡΠ΅ΡΠ΅ ΠΎΠΊΠ°Π·Π°Π½ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ»ΡΠ³ (ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠ΅Π½Π½ΠΎΡΡΡ Π³ΡΠ°ΠΆΠ΄Π°Π½ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅ΠΌΡΡ
ΡΡΠ»ΡΠ³ Π² ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΌ Π²ΠΈΠ΄Π΅), Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΈΡΠΊΠΈ ΡΠΈΡΡΠΎΠ²ΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ (ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΈΡΡΠΎΠ²ΠΎΠ³ΠΎ Π΄ΠΎΠ²Π΅ΡΠΈΡ Π³ΡΠ°ΠΆΠ΄Π°Π½ ΠΏΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Ρ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²ΠΎΠΌ). ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° Π°ΠΏΡΠΎΠ±Π°ΡΠΈΡ ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½ Π² ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌ ΡΠ°Π·ΡΠ΅Π·Π΅. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΡΠΈΠΌΠ΅Π½ΠΈΠΌΠΎΡΡΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½Π°Ρ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ Π΅Π³ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ ΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΈΠ½Π΄Π΅ΠΊΡΠ° ΠΎΡ ΡΡΠΎΠ²Π½Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ, Π·Π°Π½ΡΡΠΎΡΡΠΈ, Π΄ΠΎΡ
ΠΎΠ΄ΠΎΠ² ΠΈ ΡΡΠ±Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ, ΡΠ°ΠΊ ΠΈ ΡΠ°Π·Π»ΠΈΡΠΈΡΠΌΠΈ Π² Π΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΠΈ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎ-ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ. ΠΡΠΈ ΡΡΠΎΠΌ ΡΡΠΎΠ²Π΅Π½Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½ Ρ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Ρ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΠ½ΡΠΌΠΈ. ΠΡΠΎ ΠΎΠ·Π½Π°ΡΠ°Π΅Ρ, ΡΡΠΎ Π΄Π»Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΡΠΈΡΡΠΎΠ²ΠΎΠ³ΠΎ Π½Π΅ΡΠ°Π²Π΅Π½ΡΡΠ²Π° ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΡ
ΡΠ΅Π³ΠΈΠΎΠ½ΠΎΠ² Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΡΡ ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΡΠΉ Π΄ΠΎΡΡΡΠΏ ΠΊ ΡΠ΅ΡΠΈ ΠΠ½ΡΠ΅ΡΠ½Π΅Ρ; Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΠΏΡΠΎΠ΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΈ ΡΠΈΡΡΠΎΠ²ΡΡ
ΠΊΠ°Π½Π°Π»ΠΎΠ² Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈΠ³ΡΠ°ΡΡ ΠΈ ΡΠ°ΠΊΡΠΎΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠ°ΠΏΠΈΡΠ°Π»Π°. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠ΅Π½ΠΊΠ° ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½ ΡΡΠ΅Π±ΡΠ΅Ρ ΡΡΠ΅ΡΠ° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, ΠΎΡΡΠ°ΠΆΠ°ΡΡΠΈΡ
Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠ΅, ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΡΠ΅ ΠΈ ΠΊΠΎΠ½Π΅ΡΠ½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°ΠΊΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΈΡΠΊΠΈ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΠΎΠΌ ΠΊ Β«ΡΠΈΡΡΠ΅Β». Π ΡΠ°ΡΡΠΈ ΠΎΠΊΠ°Π·Π°Π½ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ»ΡΠ³ Π΄Π»Ρ ΡΠ°ΠΊΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΠΈΠ½Π΄Π΅ΠΊΡ ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½. ΠΠ°Π»ΡΠ½Π΅ΠΉΡΠΈΠ΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² ΡΡΠ΅ΡΠ΅ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½ ΡΠ²ΡΠ·Π°Π½Ρ Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π²Π»ΠΈΡΠ½ΠΈΡ Π΄ΠΎΠ²Π΅ΡΠΈΡ Π³ΡΠ°ΠΆΠ΄Π°Π½ ΠΊ ΠΎΡΠ³Π°Π½Π°ΠΌ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π½Π° ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΈΡΡΠΎΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° ΠΈ Π³ΡΠ°ΠΆΠ΄Π°Π½, Π° ΡΠ°ΠΊΠΆΠ΅ Ρ ΡΡΠ΅ΡΠΎΠΌ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΡΠ°ΠΆΠ΄Π°Π½ ΠΈ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π° Π² ΡΠ°ΠΌΠΊΠ°Ρ
ΠΈΠ½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ (Π²ΡΡΠ°Π±ΠΎΡΠΊΠΈ ΠΈ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΠΎΠ»ΠΈΡΠΈΠΊΠΈ, ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎ-Π½Π°Π΄Π·ΠΎΡΠ½ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ). Π Π΅Π°Π»ΠΈΠ·Π°ΡΠΈΡ ΡΡΠΈΡ
Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ ΠΏΠΎΡΡΠ΅Π±ΡΠ΅Ρ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΡ ΠΈΠΌΠ΅ΡΡΠ΅ΠΉΡΡ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±Π°Π·Ρ
INTRANASAL INHALATIONS OF BIOACTIVE FACTORS PRODUCED BY M2 MACROPHAGES IN THE TREATMENT OF PATIENTS WITH ORGANIC BRAIN SYNDROME
The aim of present study was to evaluate safety and clinical efficacy of inhalatory immunotherapy based on intranasal delivery of bioactive factors produced by M2 macrophages applied for treatment of patients with organic brain syndrome (OBS).Materials and methods. The study under the NCT02957123 protocol (www.ClinicalTrails.gov) included thirty patients with OBS of various genesis (10 men and 20 women aged 18 to 81; Me, 62.5 years). Neurological assessment and the levels of 32 cytokines in the blood serum of patients were evaluated before and 2-3 days after completion of inhalation immunotherapy.Intranasal inhalations of cell-free culture medium of M2 macrophages (2 mL, once a day for 28-30 days) were safe and well tolerated. None of 30 treated patients had severe adverse events and serious treatmentrelated side reactions. One month after starting the inhalations, a positive dynamics in neurological status was noted in all the patients. A marked clinical response was documented in twenty out of thirty patients (67%), which manifested as improvement, according to all scales and questionnaires. The neurological improvement was not reversed over 6 months of follow-up period. In other ten patients (33%), a moderate clinical response was shown as improvement of individual scores. The positive changes were as follows: 1) a 43% decrease in anxiety and depression scores (according to HADS scale, pU = 0.0008); 2) an increase of total motor activity (stability and gait) by 25%, pU = 0.0001); 3) correction of cognitive functions (MoCa test, pU = 0.007); 4) reduced number and intensity of the disease symptoms by 52% (pU = 0.0001). This marked clinical response to immunotherapy is shown to be associated with correction/normalization of serum hepatocyte growth factor (HGF) level.Conclusion. Inhalation immunotherapy based on intranasal delivery of bioactive factors produced by M2 macrophages can improve neurological and functional recovery in patients with organic brain syndrome
IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
The study was devoted to development of non-invasive methods for diagnosis of liver fibrosis in patients with chronic viral hepatitis (CVH). The stepwise logistic multivariate regression analysis of biochemical (PTI, glucose, albumin, AST, LDH) and immunological parameters (the functional activity of neutrophils and monocytes, the relative content of CD8+ T- and CD19+B-cells) was used for the establishment of diagnostic model. Based on the multiple regression analysis we derived a 2 novel Integral Indexes of Liver Fibrosis (IILF-biochem and IILF-immun, respectively). It is shown that IILF-biochem allows, without resorting to liver biopsy to predict the appropriate stage of fibrosis in CHV patients with diagnostic accuracy of 86β87 %, and in combination with IILF β at 97.7 %
Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRETβDD) study, a collaborative study carried out in 14 countries
Aims
To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries.
Methods
People with diabetes aged 18β65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected.
Results
A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (PPPPP<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0β29.6%).
Conclusions
Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes
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