Completeness of case ascertainment and survival time error in English cancer registries: impact on 1-year survival estimates.

BACKGROUND: It has been suggested that cancer registries in England are too dependent on processing of information from death certificates, and consequently that cancer survival statistics reported for England are systematically biased and too low. METHODS: We have linked routine cancer registration records for colorectal, lung, and breast cancer patients with information from the Hospital Episode Statistics (HES) database for the period 2001-2007. Based on record linkage with the HES database, records missing in the cancer register were identified, and dates of diagnosis were revised. The effects of those revisions on the estimated survival time and proportion of patients surviving for 1 year or more were studied. Cases that were absent in the cancer register and present in the HES data with a relevant diagnosis code and a relevant surgery code were used to estimate (a) the completeness of the cancer register. Differences in survival times calculated from the two data sources were used to estimate (b) the possible extent of error in the recorded survival time in the cancer register. Finally, we combined (a) and (b) to estimate (c) the resulting differences in 1-year cumulative survival estimates. RESULTS: Completeness of case ascertainment in English cancer registries is high, around 98-99%. Using HES data added 1.9%, 0.4% and 2.0% to the number of colorectal, lung, and breast cancer registrations, respectively. Around 5-6% of rapidly fatal cancer registrations had survival time extended by more than a month, and almost 3% of rapidly fatal breast cancer records were extended by more than a year. The resulting impact on estimates of 1-year survival was small, amounting to 1.0, 0.8, and 0.4 percentage points for colorectal, lung, and breast cancer, respectively. INTERPRETATION: English cancer registration data cannot be dismissed as unfit for the purpose of cancer survival analysis. However, investigators should retain a critical attitude to data quality and sources of error in international cancer survival studies

Diagnostics of Stresses and Strains of Hard Bio-tissues in vivo

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.The formation and dynamics of bio-speckle fields formed by hard bio-tissues of the oral cavity in vivo irradiated with low-intensity laser light are analyzed. Novel experimental methods for diagnostics of the stressed-strained state of the dental system and orthodontic and orthopedic structures based on speckle technologies and cross-correlation analysis of bio-speckle fields are described. The cross-correlation analysis of the laser bio-speckle fields permits quantitative determination of the micro displacement of the hard biotissues and orthodontic and orthopedic structural elements in the range from 1 to 100 μm with submicron accuracy and a spatial resolution of up to 50 μm. This suffices for detecting micro deviations of the indices of the stressed-strained state of the elements, used in medical orthodontic practice, and their changes with time in the period of the investigation and after a functional test

Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells.

β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic function of β-catenin. However, the effect of Siah1 on the cell membrane bound β-catenin has not been studied. In this study, we identified that the carcinogenic bacterium H. pylori increased ETS2 transcription factor-mediated Siah1 protein expression in gastric cancer cells (GCCs) MKN45, AGS and Kato III. Siah1 protein level was also noticeably higher in gastric adenocarcinoma biopsy samples as compared to non-cancerous gastric epithelia. Siah1 knockdown significantly decreased invasiveness and migration of H. pylori-infected GCCs. Although, Siah1 could not increase degradation of the cytosolic β-catenin and its nuclear translocation, it enhanced degradation of the membrane-bound β-catenin in the infected GCCs. This loss of membrane-bound pool of β-catenin was not associated with the proteasomal degradation of E-cadherin. Thus, this work delineated the role of Siah1 in increasing invasiveness of H. pylori-infected GCCs

High rate of extrapair paternity in a human population demonstrates diversity in human reproductive strategies.

Among nonhuman species, social monogamy is rarely accompanied by complete fidelity. Evolutionary theory predicts that the rate of extrapair paternity (EPP) should vary according to socioecological conditions. In humans, however, geneticists contend that EPP is negligible and relatively invariable. This conclusion is based on a limited set of studies, almost all of which describe European-descent groups. Using a novel, double-blind method designed in collaboration with a community of Himba pastoralists, we find that the rate of EPP in this population is 48%, with 70% of couples having at least one EPP child. Both men and women were very accurate at detecting cases of EPP. These data suggest that the range of variation in EPP across human populations is substantially greater than previously thought. We further show that a high rate of EPP can be accompanied by high paternity confidence, which highlights the importance of disaggregating EPP from the notion of "cuckoldry.

Using card sorting technique to classify requirements change

Requirements Volatility is considered to be a major source of risk to the management of large and complex software projects. The ability to characterise the nature and origins of requirements change during software development is important and can lead organisations towards more effective management of changing requirements. This paper focuses on a study to establish how practitioners classify requirements change requests. We used the Card Sorting method to identify categories of change requests that software developers use in practice. Card sorting is a knowledge elicitation method that is commonly used for capturing information about different ways of representing domain knowledge. This study has allowed us to get valuable insights into the way practitioners classify change requests and to understand their perspectives on classification. This classification is a valuable source of information in prioritizing change requests and assessing their impact. Our findings from the card sorting exercise further reveal that the criteria used for categorization are related to the role the practitioner plays in the software development team and the nature and extent of their responsibilities. © 2004 IEEE

Implementing a BIM collaborative workflow in the UK construction market

BIM Level 2, as defined by the UK government, sets out processes and standards that formalise and regulate the collaborative methods for producing, sharing and exchanging information during different stages of any construction project. For overseas organisations that are looking to invest in the UK construction market, they will most certainly need to consider developing their understanding and ability related to BIM in order to enable developing their capability and competency to compete. This paper presents a case study that focuses on the implementation of collaborative based BIM workflow at a large Chinese engineering and construction organisation, which has recently established operations in the UK. The BIM implementation has been achieved under a Knowledge Exchange Partnership framework between the organisation and an academic institution in the UK. The main aim for this partnership project was to transform the organisation’s traditional workflow to achieve a BIM based collaborative workflow, and to comply with BIM Level 2 requirements. The case study has been achieved by adopting an action research methodology, whereby the project affiliate was an active part of the implementation project and was managing and coordinating the partnership project between the organisation and academic partner. Results to date from the project will be documented in this paper. This includes highlighting key challenges, adopted strategies and tactics to overcome the obstacles, pockets of improvements and potential areas for future development