107 research outputs found
Light Hadron Spectrum in Quenched Lattice QCD with Staggered Quarks
Without chiral extrapolation, we achieved a realistic nucleon to (\rho)-meson
mass ratio of (m_N/m_\rho = 1.23 \pm 0.04 ({\rm statistical}) \pm 0.02 ({\rm
systematic})) in our quenched lattice QCD numerical calculation with staggered
quarks. The systematic error is mostly from finite-volume effect and the
finite-spacing effect is negligible. The flavor symmetry breaking in the pion
and (\rho) meson is no longer visible. The lattice cutoff is set at 3.63 (\pm)
0.06 GeV, the spatial lattice volume is (2.59 (\pm) 0.05 fm)(^3), and bare
quarks mass as low as 4.5 MeV are used. Possible quenched chiral effects in
hadron mass are discussed.Comment: 5 pages and 5 figures, use revtex
Continuum Limit of from 2+1 Flavor Domain Wall QCD
We determine the neutral kaon mixing matrix element in the continuum
limit with 2+1 flavors of domain wall fermions, using the Iwasaki gauge action
at two different lattice spacings. These lattice fermions have near exact
chiral symmetry and therefore avoid artificial lattice operator mixing.
We introduce a significant improvement to the conventional NPR method in
which the bare matrix elements are renormalized non-perturbatively in the
RI-MOM scheme and are then converted into the MSbar scheme using continuum
perturbation theory. In addition to RI-MOM, we introduce and implement four
non-exceptional intermediate momentum schemes that suppress infrared
non-perturbative uncertainties in the renormalization procedure. We compute the
conversion factors relating the matrix elements in this family of RI-SMOM
schemes and MSbar at one-loop order. Comparison of the results obtained using
these different intermediate schemes allows for a more reliable estimate of the
unknown higher-order contributions and hence for a correspondingly more robust
estimate of the systematic error. We also apply a recently proposed approach in
which twisted boundary conditions are used to control the Symanzik expansion
for off-shell vertex functions leading to a better control of the
renormalization in the continuum limit.
We control chiral extrapolation errors by considering both the NLO SU(2)
chiral effective theory, and an analytic mass expansion. We obtain
B_K^{\msbar}(3 GeV) = 0.529(5)_{stat}(15)_\chi(2)_{FV}(11)_{NPR}. This
corresponds to . Adding
all sources of error in quadrature we obtain , with an overall combined error of 3.6%.Comment: 65 page
Localization and chiral symmetry in 2+1 flavor domain wall QCD
We present results for the dependence of the residual mass of domain wall
fermions (DWF) on the size of the fifth dimension and its relation to the
density and localization properties of low-lying eigenvectors of the
corresponding hermitian Wilson Dirac operator relevant to simulations of 2+1
flavor domain wall QCD. Using the DBW2 and Iwasaki gauge actions, we generate
ensembles of configurations with a space-time volume and an
extent of 8 in the fifth dimension for the sea quarks. We demonstrate the
existence of a regime where the degree of locality, the size of chiral symmetry
breaking and the rate of topology change can be acceptable for inverse lattice
spacings GeV.Comment: 59 Pages, 23 figures, 1 MPG linke
Deconfinement transition and string tensions in SU(4) Yang-Mills Theory
We present results from numerical lattice calculations of SU(4) Yang-Mills
theory. This work has two goals: to determine the order of the finite
temperature deconfinement transition on an lattice and to study the
string tensions between static charges in the irreducible representations of
SU(4). Motivated by Pisarski and Tytgat's argument that a second-order
SU() deconfinement transition would explain some features of the SU(3)
and QCD transitions, we confirm older results on a coarser, , lattice.
We see a clear two-phase coexistence signal, characteristic of a first-order
transition, at on a lattice, on which we also
compute a latent heat of . Computing
Polyakov loop correlation functions we calculate the string tension at finite
temperature in the confined phase between fundamental charges, ,
between diquark charges, , and between adjoint charges . We
find that , and our result for the adjoint string
tension is consistent with string breaking.Comment: 10 pages with included figures. For version 2: New calculation and
discussion of latent heat added; 2 new figures and 1 new table. Typo in
abstract corrected for v3. To appear in Physical Review
Comparative Genetic Mapping and Discovery of Linkage Disequilibrium Across Linkage Groups in White Clover (Trifolium repens L.)
White clover (Trifolium repens L.) is an allotetraploid species (2n = 4X = 32) that is widely distributed in temperate regions and cultivated as a forage legume. In this study, we developed expressed sequence tag (EST)–derived simple sequence repeat (SSR) markers, constructed linkage maps, and performed comparative mapping with other legume species. A total of 7982 ESTs that could be assembled into 5400 contigs and 2582 singletons were generated. Using the EST sequences that were obtained, 1973 primer pairs to amplify EST-derived SSR markers were designed and used for linkage analysis of 188 F1 progenies, which were generated by a cross between two Japanese plants, ‘273-7’ and ‘T17-349,’ with previously published SSR markers. An integrated linkage map was constructed by combining parental-specific maps, which consisted of 1743 SSR loci on 16 homeologous linkage groups with a total length of 2511 cM. The primer sequences of the developed EST-SSR markers and their map positions are available on http://clovergarden.jp/. Linkage disequilibrium (LD) was observed on 9 of 16 linkage groups of a parental-specific map. The genome structures were compared among white clover, red clover (T. pratense L.), Medicago truncatula, and Lotus japonicus. Macrosynteny was observed across the four legume species. Surprisingly, the comparative genome structure between white clover and M. truncatula had a higher degree of conservation than that of the two clover species
A Lattice Study of the Nucleon Excited States with Domain Wall Fermions
We present results of our numerical calculation of the mass spectrum for
isospin one-half and spin one-half non-strange baryons, i.e. the ground and
excited states of the nucleon, in quenched lattice QCD. We use a new lattice
discretization scheme for fermions, domain wall fermions, which possess almost
exact chiral symmetry at non-zero lattice spacing. We make a systematic
investigation of the negative-parity spectrum by using two distinct
interpolating operators at on a
lattice. The mass estimates extracted from the two operators are consistent
with each other. The observed large mass splitting between this state,
, and the positive-parity ground state, the nucleon N(939), is well
reproduced by our calculations. We have also calculated the mass of the first
positive-parity excited state and found that it is heavier than the
negative-parity excited state for the quark masses studied.Comment: 46 pages, REVTeX, 11 figures included, revised version accepted for
publication in Phys. Rev.
The G-Protein β3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia
<p>Abstract</p> <p>Background</p> <p>Although familial clustering of functional dyspepsia (FD) has been reported, the role of genetics in the susceptibility to FD is still not well understood. Several reports indicate an association between FD and G-protein β3 (GNB3) subunit gene polymorphism (C825T); however, these studies had small sample sizes and the findings are inconclusive. In the present study we clarified the association between GNB3 gene polymorphism and dyspepsia in a large population of Japanese subjects who visited a hospital for annual health check-up.</p> <p>Methods</p> <p>Subjects with significant upper gastrointestinal findings were excluded. Subjects with dyspeptic symptoms were divided into either a postprandial distress syndrome (PDS) group or an epigastric pain syndrome (EPS) group according to the Rome III criteria. The presence of the GNB3 C825T polymorphism was then evaluated and logistic regression analysis was used to test all variables.</p> <p>Results</p> <p>The GNB3 genotype distribution in subjects without dyspepsia was 191 CC (25.1%), 368 TC (48.4%), and 202 TT (26.5%) and 17 CC (25.0%), 29 TC (42.6%), and 22 TT (32.4%) in subjects with dyspepsia. No significant correlation was found between the GNB3 825TT genotype and dyspepsia. However, the TT genotype was significantly associated with subjects with EPS-like symptoms (odds ratio (OR) = 2.00, 95% confidence interval (CI); 1.07-3.76) compared to the CT/CC genotype adjusted for gender and age. No significant correlation was found between GNB3 polymorphism and PDS-like symptoms (OR = 0.68, 95% CI; 0.31-1.51). With the exclusion of subjects with both EPS- and PDS-like symptoms, only the TT genotype was significantly associated with EPS-like symptoms (OR = 2.73, 95% CI; 1.23-5.91).</p> <p>Conclusion</p> <p>The homozygous GNB3 825T allele influences the susceptibility to EPS-like dyspepsia.</p
An interspecific linkage map of SSR and intronic polymorphism markers in tomato
Despite the collection and availability of abundant tomato genome sequences, PCR-based markers adapted to large scale analysis have not been developed in tomato species. Therefore, using public genome sequence data in tomato, we developed three types of DNA markers: expressed sequence tag (EST)-derived simple sequence repeat (SSR) markers (TES markers), genome-derived SSR markers (TGS markers) and EST-derived intronic polymorphism markers (TEI markers). A total of 2,047 TES, 3,510 TGS and 674 TEI markers were established and used in the polymorphic analysis of a cultivated tomato (Solanum lycopersicum) ‘LA925’ and its wild relative Solanum pennellii ‘LA716’, parents of the Tomato-EXPEN 2000 mapping population. The polymorphic ratios between parents revealed by the TES, TGS and TEI markers were 37.3, 22.6 and 80.0%, respectively. Those showing polymorphisms were used to genotype the Tomato-EXPEN 2000 mapping population, and a high-density genetic linkage map composed of 1,433 new and 683 existing marker loci was constructed on 12 chromosomes, covering 1,503.1 cM. In the present map, 48% of the mapped TGS loci were located within heterochromatic regions, while 18 and 21% of TES and TEI loci, respectively, were located in heterochromatin. The large number of SSR and SNP markers developed in this study provide easily handling genomic tools for molecular breeding in tomato. Information on the DNA markers developed in this study is available at http://www.kazusa.or.jp/tomato/
Redox Modulation at Work: Natural Phytoprotective Polysulfanes From Alliums Based on Redox-Active Sulfur
Purpose of review: This article provides a brief overview of natural phytoprotective products of allium with a special focus on the therapeutic potential of diallyl polysulfanes from garlic, their molecular targets and their fate in the living organisms. A comprehensive overview of antimicrobial and anticancer properties of published literature is presented for the reader to understand the effective concentrations of polysulfanes and their sensitivity towards different human pathogenic microbes, fungi, and cancer cell lines. Recent findings: The article finds polysulfanes potentials as new generation novel antibiotics and chemo preventive agent. The effective dose rates of polysulfanes for antimicrobial properties are in the range of 0.5–40 mg/L and for anticancer 20–100 μM. The molecular targets for these redox modulators are mainly cellular thiols as well as inhibition and/or activation of certain cellular proteins in cancer cell lines. Summary: Antimicrobial and anticancer activities of polysulfanes published in the literature indicate that with further development, they could be promising candidates for cancer prevention due to their selectivity towards abnormal cells
Macrosomia and large for gestational age in Asia:One size does not fit all
Macrosomia, usually defined as infant birth weight of >= 4000 g, does not consider gestational age, sex, or country/region-specific differences in mean birth weight and maternal body weight. This issue is particularly relevant for Asia, where 60% of the world's population lives, due to variations in maternal size and birth weights across populations. Large for gestational age (LGA), defined as birth weight > 90th centile, is a more sensitive measure as it considers gestational age and sex, though it is dependent on the choice of growth charts. We aimed to review reporting of macrosomia and LGA in Asia. We reviewed the literature on prevalence and risk of macrosomia and LGA in Asia over the last 29 years. Prevalence of macrosomia ranged from 0.5% (India) to 13.9% (China) while prevalence of LGA ranged from 4.3% (Korea) to 22.1% (China), indicating substantial variation in prevalence within and between Asian countries. High pre-pregnancy body mass index, excessive gestational weight gain, and impaired glucose tolerance conferred risk of macrosomia/LGA. Incidence of macrosomia and LGA varies substantially within and between Asian countries, as do the growth charts and definitions. The latter makes it impossible to make comparisons but suggests differences in intrauterine growth between populations. Reporting LGA, using standardized country/regional growth charts, would better capture the incidence of high birth weight and allow for comparison and identification of contributing factors. Better understanding of local drivers of excessive intrauterine growth could enable development of improved strategies for prevention and management of LGA
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