Features of the system of antioxidant protection and lipid peroxidation in microangiopathies against type 2 diabetes mellitus

The article presents the results of an experimental study of the AOР and LPО system in animals simulated complications of the microcirculatory tract (diabetic retinopathy, diabetic nephropathy) on the background of type 2 diabetes. It was found that in the group of animals with type 2 diabetes increased the level of DC, TBCproducts and MDA; catalase and FG levels decreased. In animals with simulated DN, AOP disorders were more pronounced compared to animals with DR. This trend can be explained by the fact that in addition to hyperglycemia in these animals, the excessive formation of free radicals contributes to metabolic shifts in ischemic areas of tissues and organs. Disturbance of balance in AOP and LPO in type 2 diabetes triggers a pathogenetic cascade of development of complications of the microcirculatory tract and is accompanied by a tendency to further increase the generation of reactive oxygen species and activation of POL in microangiopathies

Correction of endothelial dysfunction among patients suffering from diabetes mellitus

The number of patients with diabetes mellitus (DM) according to WHO is constantly increasing. At the same time, it is known that one of the main pathogenetic links of diabetes is excessive activation of processes of free radical oxidation. Literary sources indicate that phenolic compounds are effectively acting as synergists and regulators of the antioxidant system, the most numerous of which are flavonoids, including anthocyanins. A number of researchers distinguish flavonoids as promising endothelioprotectors under different pathological conditions. Goal: to investigate the dynamics of the content of markers of endothelial dysfunction among patients with diabetes mellitus correcting the pro- and antioxidant system with the help of flavonoids. Materials and methods. The study involved 40 patients with type 2 diabetes at the age of 40 to 60 years. To study the effectiveness of flavonoids under these conditions, we chose the drug "GEMOGLOBIN NECTAR PLUS". The first stage of the study was the determination of Willebrand factor and endothelin-1 in the blood serum before the flavonoids were taken. The second stage of the study was the determination of the test markers of endothelial dysfunction 2 months after the start of the regular intake of the drug anthocyanins, which are known as flavonoids. As a result of our study, the following data were obtained: The relationship between pro and antioxidant system disorders and endothelial dysfunction among patients with diabetes mellitus was confirmed. The normalization of Willebrand factor among patients taking flavonoids according to data obtained before the use of the drug was proved. There was a change in the vaconstrictor-vasodilatation potential under the action of the anthocyanin concentrate directing to the reducing of pathological vasoconstriction and, consequently, normalization of blood supply processes. The drug "GEMOGLOBIN NECTAR PLUS", being a powerful antioxidant, significantly improves the functional state of the endothelium

Коррекция антоцианами эндотелиальной дисфункции у пациентов, страдающих сахарным диабетом

The number of patients with diabetes mellitus (DM) according to WHO is constantly increasing. At the same time, it is known that one of the main pathogenetic links of diabetes is excessive activation of processes of free radical oxidation. Literary sources indicate that phenolic compounds are effectively acting as synergists and regulators of the antioxidant system, the most numerous of which are flavonoids, including anthocyanins. A number of researchers distinguish flavonoids as promising endothelioprotectors under different pathological conditions. Goal: to investigate the dynamics of the content of markers of endothelial dysfunction among patients with diabetes mellitus correcting the pro- and antioxidant system with the help of flavonoids. Materials and methods. The study involved 40 patients with type 2 diabetes at the age of 40 to 60 years. To study the effectiveness of flavonoids under these conditions, we chose the drug "GEMOGLOBIN NECTAR PLUS". The first stage of the study was the determination of Willebrand factor and endothelin-1 in the blood serum before the flavonoids were taken. The second stage of the study was the determination of the test markers of endothelial dysfunction 2 months after the start of the regular intake of the drug anthocyanins, which are known as flavonoids. As a result of our study, the following data were obtained: The relationship between pro and antioxidant system disorders and endothelial dysfunction among patients with diabetes mellitus was confirmed. The normalization of Willebrand factor among patients taking flavonoids according to data obtained before the use of the drug was proved. There was a change in the vaconstrictor-vasodilatation potential under the action of the anthocyanin concentrate directing to the reducing of pathological vasoconstriction and, consequently, normalization of blood supply processes. The drug "GEMOGLOBIN NECTAR PLUS", being a powerful antioxidant, significantly improves the functional state of the endothelium.Количество пациентов, страдающих сахарным диабетом (СД) по данным ВОЗ постоянно возрастает. В то же время известно, что одним из основных патогенетических звеньев СД является чрезмерная активизация процессов свободнорадикального окисления. Литературные источники свидетельствуют о том, что в роли синергистов и регуляторов антиоксидантой системы эффективно выступают фенольные соединения, наиболее многочисленной группой которых являются флавоноиды, к которым относятся и антоцианы. Ряд исследователей выделяют флавоноиды как перспективные эндотелиопротекторы при разных патологических состояниях. Цель: исследовать динамики содержания маркеров эндотелиальной дисфункции у пациентов, страдающих сахарным диабетом при коррекции про- и антиоксидантной системы с помощью флавоноидов. Материалы и методы. В исследовании приняли участие 40 пациентов, страдающих сахарным диабетом 2-го типа в возрасте от 40 до 60 лет. Для исследования эффективности флавоноидов в данных условиях нами был выбран препарат «ГЕМОГЛОБИН НЕКТАР ПЛЮС». Первый этап исследования – определение фактора Виллебранда и эндотелина-1 в сыворотке крови до начала приема флавоноидов. Второй этап исследования – определение исследуемых маркеров дисфункции эндотелия через 2 месяца после начала регулярного приема препарата антоцианов, которые, как известно, являются флавоноидами. В результате нашего исследования были получены следующие данные: Подтверждается взаимосвязь нарушений про- и антиоксидантной системы и дисфункции эндотелия у пациентов, страдающих сахарным диабетом. Доказана нормализация фактора Виллебранда у пациентов, принимающих флавоноиды по отношению к данным, полученным до начала употребления препарата. Отмечается изменение ваконстрикторно-вазодилятационного потенциала под действием концентрата антоцианов в сторону уменьшения патологической вазоконстрикции и, соответственно нормализации процессов кровоснабжения. Препарат «ГЕМОГЛОБИН НЕКТАР ПЛЮС», являясь мощным антиоксидантом, существенно улучшает функциональное состояние эндотелия

Effect of Cr spacer on structural and magnetic properties of Fe/Gd multilayers

In this work we analyse the role of a thin Cr spacer between Fe and Gd layers on structure and magnetic properties of a [Fe(35A)/Cr(tCr)/Gd(50A)/Cr(tCr)]x12 superlattice. Samples without the Cr spacer (tCr=0) and with a thin tCr=4A are investigated using X-ray diffraction, polarized neutron and resonance X-ray magnetic reflectometry, SQUID magnetometery, magneto-optical Kerr effect and ferromagnetic resonance techniques. Magnetic properties are studied experimentally in a wide temperature range 4-300K and analysed theoretically using numerical simulation on the basis of the mean-field model. We show that a reasonable agreement with the experimental data can be obtained considering temperature dependence of the effective field parameter in gadolinium layers. The analysis of the experimental data shows that besides a strong reduction of the antiferromagnetic coupling between Fe and Gd, the introduction of Cr spacers into Fe/Gd superlattice leads to modification of both structural and magnetic characteristics of the ferromagnetic layers

Magnetoresistive study of antiferromagnetic--weak ferromagnetic transition in single-crystal La2_{2}CuO4+δ_{4+\delta}

The resistive measurements were made to study the magnetic field-induced antiferromagnetic (AF) - weak ferromagnetic (WF) transition in La$_2$CuO$_4$ single-crystal. The magnetic field (DC or pulsed) was applied normally to the CuO$_2$ layers. The transition manifested itself in a drastic decrease of the resistance in critical fields of ~5-7 T. The study is the first to display the effect of the AF -WF transition on the conductivity of the La$_2$CuO$_4$ single-crystal in the parallel - to - CuO$_2$ layers direction. The results provide support for the 3-dimensional nature of the hopping conduction of this layered oxide.Comment: 8 pages, 7 figures, RevTe

Magnetization and ferromagnetic resonance in a Fe/Gd multilayer: Experiment and modelling

Static and dynamic magnetic properties of a [Fe(35 Å<rf)/Gd(50 Å)]12 superlattice are investigated experimentally in the temperature range 5-295 K using SQUID magnetometery and the ferromagnetic resonance (FMR) technique at frequencies 7-38 GHz. The obtained magnetization curves and FMR spectra are analysed theoretically using numerical simulation on the basis of the effective field model. At every given temperature, both static and resonance experimental data can be approximated well within the proposed model. However, a considerable temperature dependence of the effective field parameter in gadolinium layers has to be taken into account to achieve reasonable agreement with the experimental data in the entire temperature range studied. To describe the peculiarities of experimental FMR spectra, a non-local diffusion-type absorption term in Landau-Lifshitz equations is considered in addition to the Gilbert damping term. Possible reasons for the observed effects are discussed. © 2017 IOP Publishing Ltd

The Association between ATM IVS 22-77 T>C and Cancer Risk: A Meta-Analysis

BACKGROUND AND OBJECTIVES: It has become increasingly clear that ATM (ataxia-telangiectasia-mutated) safeguards genome stability, which is a cornerstone of cellular homeostasis, and ATM IVS 22-77 T>C affects the normal activity of ATM proteins. However, the association between the ATM IVS 22-77 T>C genetic variant and cancer risk is controversial. Therefore, we conducted a systematic meta-analysis to estimate the overall cancer risk associated with the polymorphism and to quantify any potential between-study heterogeneity. METHODS: A total of nine studies including 4,470 cases and 4,862 controls were analyzed for ATM IVS 22-77 T>C association with cancer risk in this meta-analysis. Heterogeneity among articles and their publication bias were also tested. RESULTS: Our results showed that no association reached the level of statistical significance in the overall risk. Interestingly, in the stratified analyses, we observed an inverse relationship in lung and breast cancer. CONCLUSION: Further functional research on the ATM mechanism should be performed to explain the inconsistent results in different cancer types