STEREO SELECTIVE SYNTHESIS OF NOVEL PYRAZOLE AND COUMARIN APPENDED BRIDGED PYRANS AS ANTIMICROBIAL AGENTS

Objectives: The aim of the present study was to synthesize a series of novel bridged pyrans as antimicrobial agents.Methods: An isomeric mixture of 3-(4-ethoxy-10-methyl-8-oxo-2-phenyl-4,8-dihydro-2H-pyrano[3',2':6,7]chromeno[4,3-c]pyrazol-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes, 2(a-f) and 3-(4-ethoxy-8-methyl-10-oxo-2-phenyl-4,10-dihydro-2H-pyrano[2',3':5,6]chromeno[4,3-c]pyrazol-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes, 3(a-f) were synthesized by the reaction of 3,3'-(7-hydroxy-4-methyl-2-oxo-2H-chromene-6,8-diyl)bis(1-phenyl-1H-pyrazole-4-carbaldehyde) 1(a-f) and ethyl alcohol in the presence of conc. H2SO4. The synthesized compounds were evaluated for their antimicrobial activity.Results: The structures of the new bridged pyran analogues 3-(4-ethoxy-10-methyl-8-oxo-2-phenyl-4,8-dihydro-2H-pyrano [3',2':6,7] chromeno [4,3-c]pyrazol-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes, 2(a-f) and 3-(4-ethoxy-8-methyl-10-oxo-2-phenyl-4,10-dihydro-2H-pyrano [2',3':5,6] chromeno[4,3-c]pyrazol-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes, 3(a-f) were confirmed by spectral studies and elemental analysis. The compounds 2e and 3e were having-CONH2 substitution and 2f and 3f were having-CSNH2 substitutions in the pyrazole rings showed antibacterial at minimum concentrations against all the tested organisms.Conclusions: Results of the antimicrobial activity reveal that some of the synthesized compounds act as potential antimicrobial agents against different fungal and bacterial organisms.Â

Analysis of Development Performance Using a Development Index Based on Factor Analysis (Old Title- Constructing Multideminsional Indexes of Economic Structure and Development)

Development involves changes in social, economic and institutional structures. Quantifying development requires a large array of variables with different characteristics often highly correlated. A factor analysis approach using inferential decisions based on computed standard errors is proposed. The significant factors are used to construct sub-indexes of structural characteristics and a new development index (DI). The properties of DI are analysed and contrasted with more traditional measures, real per capita income (RIPC) and the Human Development Index (HDI). The methodology is applied to data on 45 variables for 97 countries for 1995-2004. DI is found to have stronger discriminating power.

Smart Automation System for Office Environment

A smart automation system for office environment is being designed in this system. Various controlling systems based on lighting, ventilating, luminance are discussed respectively. Various sensors are used to extract the real time information i.e. temperature, light intensity, humidity, smoke, motion sensor are used. This data is send to ARM 11 Controller. It is then send to PC where data is saved. Through Network switch this data is send to other PC’s. The data collected is stored as database and can be accessed anytime. The data is send to the android or any internet enabled device. This system also provides need based emergency services like Ambulance call, fire alarm. Biometric fingerprint is used for security purpose. Manual mode and automatic mode are two alternative modes designed to promote the usability of smart office system. Control of electric lighting fixtures of different office spaces is done

Generating Private Recommendation System Using Multiple Homomorphic Encryption Scheme

The recommender system is important tool in online application to generate the recommendation services. Recommendations are generated by collecting the data from users need; online services access the user’s profiles for generating useful recommendations. Privacy sensitive data is used for to collect the data. Collaborative filtering technique gives privacy for sensitive data if data is misused by other service providers or leaked. Existing system uses Paillier encryption algorithm & DGK algorithm to secure user data from malicious third party as well as to protect the private data against service provider but system is more complex and inefficient. Proposed system protects the privacy of user using encrypting the sensitive data. The system uses multiple homomorphic algorithms to secure user data from service providers. The system is used to protect the confidential data of user against the service provider while providing online services. Encrypting private data is recommended and process on data to generate recommendations. To construct efficient system that does not require the active participation of the user. The experiment shows that the result that provide the security by hiding the personal data of user from third party DOI: 10.17762/ijritcc2321-8169.15076

RECENT UPDATE ON ORAL FILMS: A BENCH TO MARKET POTENTIAL

Oral films are gaining a lot of attention as a substitute approach to the conventional dosage form. Over the past few years, many of the pharmaceutical scientists throughout the world are focusing their research on oral films, trying to see the sights of oral films as a novel drug delivery system. The oral films are convenient to swallow for geriatric and pediatric patients, are self-administrable, used for systemic and local action and rapid release of a drug, which makes it an excellent system of drug delivery. This review article mainly discusses the manufacturing aspects of films and their characterization, applications and the constraints in the development of oral films along with highlights of market potential

Immunization in Periodontics: A Systematic Review

Background: Formulation of a vaccine against pathogenic microorganisms causing periodontal diseases has been under research for a decade. Many in vitro and in vivo studies havebeen made in this regard. The aim of this study is to review all preclinical (i.e. animal) and in vivo studies that presents supporting evidence for the feasibility of formulating aprophylactic human periodontal vaccine. Materials and methods: A manual and electronic literature search was made for animal studies up to 2011 that presented clinical, morphologic (alveolar bone level), and immunologic data  for the efficacy of a prophylactic periodontal vaccine. A total of 31 studies are included out of which nine are in vivo studies. Results: In vitro studies revealed a definitive inhibitory effect of vaccines over periodontal disease causing organisms and their vulnerability toward such agents. Among the studies reviewed, in vitro outnumbered the in vivo studies and there is definitely a lack in quality and quantity of human trials in this regard. Most in vitro studies have shown results in favor of vaccines preventing the periodontal diseases by action against pathogenic organisms. Conclusion: Because of the insufficient quality and quantity of human trials, no adequate evidence could be gathered to use the beneficial effects of these animal experiments to formulate a prophylactic human periodontal vaccine. Thus, good quality animal and human trials are needed in this field of vaccination against periodontal diseases.&nbsp

The Role of Applied Behaviour Analysing in Zoo Management System for Animals

This study examines the use of Applied Behaviour Analysis (ABA) in animal management systems in zoos with an emphasis on how well it enhances animal wellbeing. The goals of the study were comparing ABA-based approaches to conventional zoo management techniques and evaluating the effect of ABA on stress reduction in captive chimpanzees. Over the course of a year, information was gathered from a chosen group of chimpanzees, including baseline and post-ABA stress levels. Following the use of ABA techniques, the data from Table 1 show a consistent trend among the chimpanzees, suggesting a considerable reduction in stress levels. Strong evidence for the effectiveness of ABA in lowering stress levels in the chimpanzees was given by statistical analysis of the data (Table 2). With a high t-statistic of 8.25, the mean baseline stress level of 7.7 substantially decreased to 3.5 post-ABA treatments (p 0.05), emphasizing the significance of this reduction. With regard to reducing stress, Objective 2 compared ABA-Based and Traditional groups. Compared to the Traditional group, the ABA-Based method had a reduced baseline stress level, according to the findings in Table 3. The ABA-Based group showed a significant reduction in stress levels following ABA sessions, while the Traditional group also showed a reduction in stress levels, albeit to a lesser extent. Both strategies significantly reduced stress, according to statistical analysis (Table 4), with the ABA-Based strategy having a greater degree of statistical significance (p 0.05). This study concludes by offering empirical proof that Applied Behaviour Analysis is a useful method for enhancing animal wellbeing in the context of zoo management. The findings imply that when compared to conventional management techniques, ABA therapies can significantly lower stress levels in caged animals

Prescribing trends of HMG Co-A reductase inhibitors in outdoor patients at tertiary care teaching hospital of central India: a retrospective observational study

Background: To analyze the prescribing patterns of statins a hypolipidemic agents by using HMIS database in outdoor patients at tertiary care teaching hospital of central India.Methods: In this retrospective study Using HMIS database, 1000 prescriptions were analyzed for statin use for various WHO prescription indicators using ATC code of statins, the ratio of prescribed daily dose (PDD) and defined daily dose (DDD) was calculated.Results: Atorvastatin was the only statin which was prescribed as monotherapy (61.1%), whereas as combination with aspirin (38.9%). While analyzing the prescriptions, it was found that patients having abnormal lipid profiles (51.8%) and normal lipid profiles (48.2%) were prescribed atorvastatin. Hypertension with diabetes (37%) was the most common disease followed by hypertension (21.2%) and diabetes mellitus (21%) for which atorvastatin was prescribed. The average number of drugs per prescription were 3.8±1.65.Conclusions: This study depicts the use of atorvastatin in various disease conditions, both as primary and secondary preventive measures. There was no polypharmacy. Such studies should be done to educate the physicians on good prescribing practices and to rationalize use of hypolipidemic drugs