Computation of In-bore Velocity-time and Travel-time profiles from Breech Pressure Measurements

The paper describes breech pressure measurement and also discusses the computation of velocity-time and travel-time profiles in the barrel from the instantaneous breech pressure values. The computed value of velocity at the shot out instant is obtained as the muzzle velocity. A close correlation is observed between the muzzle velocities measured by a radar and those computed from pressure-time data by this method

Instrumentation System for Thermal analysis of Electro-Explosive Devices.

A constant current pulser, with adjustable pulse width and current, is designed to evaluate thermal characteristics of electro-explosive devices (EED). The thermal response in voltage/time profile is digitised and recorded on a PC. A software for the analysis of this data has been developed. It computes the heat loss coefficient (Lambda), thermal capacity (Co) and thermal time constant (of the system. These parameters are used for the prediction of the performance EEDs during development stage and also in quality control. A computerised system developed for this purpose is also described in detail

Synthesis and interaction of thiazolo [2, 3-a] isoquinoline analog with DNA

569-573A reaction between 1-(furan-2-yl)-3,4-dihydroisoquinoline and thioglycolic acid using N,N-Dicyclohexylcarbodiimide at 0−5 °C has given 10b-(furan-2-yl)-5,6-dihydro-2H-thiazolo[2,3-a]isoquinolin-3(10bH)-one [FUIQTGA]. The interaction between FUIQTGA and DNA has been studied using UV-visible spectroscopy, fluorescence and circular dichroism techniques. Static quenching mechanism is observed from fluorescence measurements of interaction between FUIQTGA and DNA. Circular dichroism reveals the minor groove binding mode between FUIQTGA and DNA

Plasma-Driven Synthesis of Self-Supported Nickel-Iron Nanostructures for Water Electrolysis

Nickel-based electrocatalysts are deemed as promising low-cost, earth-abundant materials in the development of the next-generation alkaline and anion exchange membrane water electrolyzers. Herein, a plasma-processing technique is presented for fabricating self-supported nanostructures from planar NiFe substrates and its performance for water splitting reactions. Irradiating the samples with helium plasma results in the formation of nano-tendrils, which are affixed to the metallic substrate. This unique design not only enhances charge and mass transport, but also increases the electrochemical surface area by 3 to 4 times, as compared to the unmodified/planar surfaces. For the benchmark 10 mAcm−2geo current density, the nanostructured electrodes demonstrate overpotentials of 330 and 354 mV for oxygen evolution reaction and hydrogen evolution reaction respectively in 1 M KOH. Moving forward, application of this technique can be extended for fabricating self-supported 3D substrates (e.g., foams, felts, perforated sheets), all of which find practical applications in energy conversion and storage devices

Synthesis of substituted benzo[e][1,3]oxazino analogs

325-327A synthesis of substituted benzo[e][1,3]oxazin-4-one analogs has been carried out by two methods. One of the common procedures involves refluxing in situ generated imine with salicylic acid while other method involves one-pot three component condensation reaction between aldehyde, amine and salicylic acid using DCC. The synthesized compounds have been characterized by IR, 1H and 13C NMR spectroscopy. Melting points reported are uncorrected

Synthesis and interaction of thiazolo [2, 3-a] isoquinoline analog with DNA

A reaction between 1-(furan-2-yl)-3,4-dihydroisoquinoline and thioglycolic acid using DCC at 00-50C will give 10b-(furan-2-yl)-5,6-dihydro-2H-thiazolo[2,3-a]isoquinolin-3(10bH)-one [FUIQTGA]. The interaction between FUIQTGA and DNA was studied using UV Visible spectroscopy, fluorescence and Circular Dichroism (CD) techniques. Static quenching mechanism was observed from fluorescence measurements of interaction between FUIQTGA and DNA.  Circular Dichroism reveals the minor groove binding mode between FUIQTGA and DNA

Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server

Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167, Trp83 and Leu149 amino acid residues were found to be in contact with designed 4-Amino-7-Chloroquinoline analogs. Different modes of binding like hydrogen bonding, hydrophobic interactions, etc with designed compounds improve potential anti-dengue characteristics in silico. ADME results are in acceptable range

Mg and TiO spectral features at the near-IR: Spectrophotometric index definitions and empirical calibrations

Using the near-infrared spectral stellar library of Cenarro et al. (2001a,b), the behaviours of the Mg I line at 8807 angstrom and nearby TiO bands are analyzed in terms of the effective temperature, surface gravity, and metallicity of the library stars. New spectroscopic indices for both spectral features -namely MgI and sTiO- are defined, and their sensitivities to different signal-to-noise ratios, spectral resolutions, flux calibrations, and sky emission line residuals are characterized. The new two indices exhibit interesting properties. In particular, MgI reveals as a good indicator of the Mg abundance, whereas sTiO is a powerful dwarf-to-giant discriminator for cold spectral types. Empirical fitting polynomials that reproduce the strength of the new indices as a function of the stellar atmospheric parameters are computed, and a FORTRAN routine with the fitting functions predictions is made available. A thorough study of several error sources, non-solar [Mg/Fe] ratios, and their influence on the fitting function residuals is also presented. From this analysis, a [Mg/Fe] underabundance of ~ -0.04 is derived for the Galactic open cluster M67.Comment: Accepted for publication in MNRAS. The paper contains 19 figures and 10 tables. Table 10 is for online publication only. Related software and complementary data available at http://www.ucm.es/info/Astrof/ellipt/MgIsTiO.htm

Copolymerization of single-cell nucleic acids into balls of acrylamide gel

We show the use of 5'-Acrydite oligonucleotides to copolymerize single-cell DNA or RNA into balls of acrylamide gel (BAGs). Combining this step with split-and-pool techniques for creating barcodes yields a method with advantages in cost and scalability, depth of coverage, ease of operation, minimal cross-contamination, and efficient use of samples. We perform DNA copy number profiling on mixtures of cell lines, nuclei from frozen prostate tumors, and biopsy washes. As applied to RNA, the method has high capture efficiency of transcripts and sufficient consistency to clearly distinguish the expression patterns of cell lines and individual nuclei from neurons dissected from the mouse brain. By using varietal tags (UMIs) to achieve sequence error correction, we show extremely low levels of cross-contamination by tracking source-specific SNVs. The method is readily modifiable, and we will discuss its adaptability and diverse applications