64,037 research outputs found
Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer
Large-Scale Structures Behind the Milky Way from Near-IR Surveys
About 25% of the optical extragalactic sky is obscured by the dust and stars
of our Milky Way. Dynamically important structures might still lie hidden in
this zone. Various approaches are presently being employed to uncover the
galaxy distribution in the Zone of Avoidance (ZOA) but all suffer from
(different) limitations and selection effects.
We investigated the potential of using the DENIS NIR survey for studies of
galaxies behind the obscuration layer of our Milky Way and for mapping the
Galactic extinction. As a pilot study, we recovered DENIS I, J and K band
images of heavily obscured but optically still visible galaxies. We determined
the I, J and K band luminosity functions of galaxies on three DENIS strips that
cross the center of the nearby, low-latitude, rich cluster Abell 3627. The
extinction-corrected I-J and J-K colours of these cluster galaxies compare well
with that of an unobscured cluster. We searched for and identified galaxies at
latitudes where the Milky Way remains fully opaque (|b|
4-5mag) - in a systematic search as well as around positions of galaxies
detected with the blind HI survey of the ZOA currently conducted with the
Multibeam Receiver of the Parkes Radiotelescope.Comment: 12 pages, including 5 PS figures, LaTeX, uses crckapb.sty and
epsf.tex. Better resolved figures available upon request. To appear in
proceedings of the 3rd Euroconference (Meudon, France, June 1997) on ``The
Impact of Near IR Surveys'', Kluwer 199
Holographic Screening Length in a Hot Plasma of Two Sphere
We study the screening length of a quark-antiquark pair moving in a hot
plasma living in two sphere manifold using AdS/CFT correspondence where
the background metric is four dimensional Schwarzschild-AdS black hole. The
geodesic solution of the string ends at the boundary is given by a stationary
motion in the equatorial plane as such the separation length of
quark-antiquark pair is parallel to the angular velocity . The
screening length and the bound energy are computed numerically using
Mathematica. We find that the plots are bounded from below by some functions
related to the momentum transfer of the drag force configuration. We
compare the result by computing the screening length in the quark-antiquark
reference frame where the gravity dual are "Boost-AdS" and Kerr-AdS black
holes. Finding relations of the parameters of both black holes, we argue that
the relation between mass parameters of the Schwarzschild-AdS black
hole and of the Kerr-AdS black hole in high temperature is given by
, where is the angular momentum
parameter.Comment: Major revision: title changed, adding authors, 13 pages, 8 figures,
etc. Accepted for publication in European Physical Journal
Magnetic shape-memory effects in La2-xSrxCuO4 crystals
The magnetic field affects the motion of electrons and the orientation of
spins in solids, but it is believed to have little impact on the crystal
structure. This common perception has been challenged recently by ferromagnetic
shape-memory alloys, where the spin-lattice coupling is so strong that
crystallographic axes even in a fixed sample are forced to rotate, following
the direction of moments. One would, however, least expect any structural
change to be induced in antiferromagnets where spins are antiparallel and give
no net moment. Here we report on such unexpected magnetic shape-memory effects
that take place ironically in one of the best-studied 2D antiferromagnets,
La2-xSrxCuO4 (LSCO). We find that lightly-doped LSCO crystals tend to align
their b axis along the magnetic field, and if the crystal orientation is fixed,
this alignment occurs through the generation and motion of crystallographic
twin boundaries. Both resistivity and magnetic susceptibility exhibit curious
switching and memory effects induced by the crystal-axes rotation; moreover,
clear kinks moving over the crystal surfaces allow one to watch the crystal
rearrangement directly with a microscope or even bare eyes.Comment: 3 pages, 4 figures; shortend version of this paper has been published
in Nature as a Brief Communicatio
Temporal trend in anthropogenic sulfur aerosol transport from Central and Eastern Europe to Israel
Spectral study of the Laplace-Beltrami operator arising in the problem of acoustic wave scattering by a quarter-plane
The Laplace-Beltrami operator on a sphere with a cut arises when considering
the problem of wave scattering by a quarter-plane. Recent methods developed
for sound-soft (Dirichlet) and sound-hard (Neumann) quarter-planes rely on an a
priori knowledge of the spectrum of the Laplace-Beltrami operator. In this paper
we consider this spectral problem for more general boundary conditions, including
Dirichlet, Neumann, real and complex impedance, where the value of the impedance
varies like being the distance from the vertex of the quarter-plane and α being
constant, and any combination of these. We analyse the corresponding eigenvalues
of the Laplace-Beltrami operator, both theoretically and numerically. We show
in particular that when the operator stops being self-adjoint, its eigenvalues are
complex and are contained within a sector of the complex plane, for which we provide
analytical bounds. Moreover, for impedance of small enough modulus |α|, the complex
eigenvalues approach the real eigenvalues of the Neumann case.R.C. Assier would like to acknowledge the support by UK EPSRC (EP/N013719/1).This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Oxford University Press
Oxidative stress in patients with laryngeal carcinoma
Background : Cancer is a multifactorial disease. Repetitive cumulative
damage of cellular organelles by oxy-free radicals are few of the
important causative factors. Aim : To assess the role of oxidative
stress in the laryngeal cancer patients in Indian population. Setting
and Design : Case control study. Materials and Methods : Level of
malondialdehyde (MDA) as a marker of oxidative stress was examined in
large cohort of control (50) and laryngeal carcinoma patients (155)
from North India. Both the controls and laryngeal carcinoma patients
were smokers. Results : In control healthy subjects MDA levels were
0.102±0.07 (0.080- 0.303, 95% CI) n mol/ml, as compared to
0.329±0.16 (0.124-0.354, 95% CI) n mol/ml in the cases of
laryngeal carcinoma patients. Three times higher serum MDA levels
indicated that there was significant oxidative stress in the subjects
having laryngeal carcinoma lesions. In addition patients with
secondaries were having MDA levels of 0.4±0.02 (0.391-0.408 95%
CI) n mol/ml, as compared to 0.57±0.03 (0.558-0.582 95% CI)n
mol/ml in group of patients without secondaries. These two values were
statistically significant as compared to control values (P< 0.01).
Conclusion : These findings suggest that in case of laryngeal carcinoma
patients, there is increase in the level of oxidative enzyme MDA. The
oxidative stress might be due to the modulation of pro-oxidant or
anti-oxidant systems in laryngeal carcinoma
Serum Level of Antioxidant Vitamins (Vitamin A, C and E) in ,i>Plasmodium falciparum Malaria Infected Children in Owerri, Eastern Nigeria
The levels of antioxidant vitamins were estimated in Plasmodium falciparum malaria infected children. Forty-three children with P.falciparum infection were selected based on the clinicalsymptoms. Twenty-two apparently healthy children with no malaria parasitaemia were included as the control subjects. P.falciparum parasitaemia and serum levels of the antioxidant vitamins (vitamin A,C and E) were determined using standard procedures. It was observed that all parameters measured were significantly lower in malaria infected children when compared with the respective control values. The relationship between malaria parasitaemia and serum concentration of vitamin E were positively correlated (r= 0.42), but vitamin A (r= -0.05) and C (-0.06) were negatively correlated. Children within 0-5 years of age had higher malarial parasitaemia (7379.82 ± 918 99/ìL) than thosebetween 6-12 years of age (5026.19 ± 1514.58/ìL), and these children had lower concentrations of vitamin A (21.27 ± 8.68 ìg/dL), C (0.45 ± 0.19 mg/dl) and E (0.69 ± 0.22 mg/dL) when comparedwith children between 6-12 years (vitamin A = 25.19 ± 8.12 ìg/dL, vitamin C = 0.53 ± 0.16 mg/ dL and vitamin E = 0.86 ± 0.41 mg/ dL). Results suggest that in Owerri, Eastern Nigeria, the degree ofmalaria parasitaemia in especially children between 0-5 years could comprise immunity (as judged by the correlation) and reduce serum antioxidant vitamin levels. Health care providers should recognizethese effects in planning malarial treatment and control programs. Changes in serum antioxidant levels during post-treatment periods should be investigated and documented
Autistic traits and loneliness in autism are associated with increased tendencies to anthropomorphise
Anveshak - A Groundtruth Generation Tool for Foreground Regions of Document Images
We propose a graphical user interface based groundtruth generation tool in
this paper. Here, annotation of an input document image is done based on the
foreground pixels. Foreground pixels are grouped together with user interaction
to form labeling units. These units are then labeled by the user with the user
defined labels. The output produced by the tool is an image with an XML file
containing its metadata information. This annotated data can be further used in
different applications of document image analysis.Comment: Accepted in DAR 201
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