Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.

Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer

Large-Scale Structures Behind the Milky Way from Near-IR Surveys

About 25% of the optical extragalactic sky is obscured by the dust and stars of our Milky Way. Dynamically important structures might still lie hidden in this zone. Various approaches are presently being employed to uncover the galaxy distribution in the Zone of Avoidance (ZOA) but all suffer from (different) limitations and selection effects. We investigated the potential of using the DENIS NIR survey for studies of galaxies behind the obscuration layer of our Milky Way and for mapping the Galactic extinction. As a pilot study, we recovered DENIS I, J and K band images of heavily obscured but optically still visible galaxies. We determined the I, J and K band luminosity functions of galaxies on three DENIS strips that cross the center of the nearby, low-latitude, rich cluster Abell 3627. The extinction-corrected I-J and J-K colours of these cluster galaxies compare well with that of an unobscured cluster. We searched for and identified galaxies at latitudes where the Milky Way remains fully opaque (|b| 4-5mag) - in a systematic search as well as around positions of galaxies detected with the blind HI survey of the ZOA currently conducted with the Multibeam Receiver of the Parkes Radiotelescope.Comment: 12 pages, including 5 PS figures, LaTeX, uses crckapb.sty and epsf.tex. Better resolved figures available upon request. To appear in proceedings of the 3rd Euroconference (Meudon, France, June 1997) on ``The Impact of Near IR Surveys'', Kluwer 199

Holographic Screening Length in a Hot Plasma of Two Sphere

We study the screening length of a quark-antiquark pair moving in a hot plasma living in two sphere $S^2$ manifold using AdS/CFT correspondence where the background metric is four dimensional Schwarzschild-AdS black hole. The geodesic solution of the string ends at the boundary is given by a stationary motion in the equatorial plane as such the separation length $L$ of quark-antiquark pair is parallel to the angular velocity $\omega$. The screening length and the bound energy are computed numerically using Mathematica. We find that the plots are bounded from below by some functions related to the momentum transfer $P_c$ of the drag force configuration. We compare the result by computing the screening length in the quark-antiquark reference frame where the gravity dual are "Boost-AdS" and Kerr-AdS black holes. Finding relations of the parameters of both black holes, we argue that the relation between mass parameters $M_{Sch}$ of the Schwarzschild-AdS black hole and $M_{Kerr}$ of the Kerr-AdS black hole in high temperature is given by $M_{Kerr}=M_{Sch}(1-a^2l^2)^{3/2}$, where $a$ is the angular momentum parameter.Comment: Major revision: title changed, adding authors, 13 pages, 8 figures, etc. Accepted for publication in European Physical Journal

Magnetic shape-memory effects in La2-xSrxCuO4 crystals

The magnetic field affects the motion of electrons and the orientation of spins in solids, but it is believed to have little impact on the crystal structure. This common perception has been challenged recently by ferromagnetic shape-memory alloys, where the spin-lattice coupling is so strong that crystallographic axes even in a fixed sample are forced to rotate, following the direction of moments. One would, however, least expect any structural change to be induced in antiferromagnets where spins are antiparallel and give no net moment. Here we report on such unexpected magnetic shape-memory effects that take place ironically in one of the best-studied 2D antiferromagnets, La2-xSrxCuO4 (LSCO). We find that lightly-doped LSCO crystals tend to align their b axis along the magnetic field, and if the crystal orientation is fixed, this alignment occurs through the generation and motion of crystallographic twin boundaries. Both resistivity and magnetic susceptibility exhibit curious switching and memory effects induced by the crystal-axes rotation; moreover, clear kinks moving over the crystal surfaces allow one to watch the crystal rearrangement directly with a microscope or even bare eyes.Comment: 3 pages, 4 figures; shortend version of this paper has been published in Nature as a Brief Communicatio

Spectral study of the Laplace-Beltrami operator arising in the problem of acoustic wave scattering by a quarter-plane

The Laplace-Beltrami operator on a sphere with a cut arises when considering the problem of wave scattering by a quarter-plane. Recent methods developed for sound-soft (Dirichlet) and sound-hard (Neumann) quarter-planes rely on an a priori knowledge of the spectrum of the Laplace-Beltrami operator. In this paper we consider this spectral problem for more general boundary conditions, including Dirichlet, Neumann, real and complex impedance, where the value of the impedance varies like $\textit{α/=r, r}$ being the distance from the vertex of the quarter-plane and α being constant, and any combination of these. We analyse the corresponding eigenvalues of the Laplace-Beltrami operator, both theoretically and numerically. We show in particular that when the operator stops being self-adjoint, its eigenvalues are complex and are contained within a sector of the complex plane, for which we provide analytical bounds. Moreover, for impedance of small enough modulus |α|, the complex eigenvalues approach the real eigenvalues of the Neumann case.R.C. Assier would like to acknowledge the support by UK EPSRC (EP/N013719/1).This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Oxford University Press

Oxidative stress in patients with laryngeal carcinoma

Background : Cancer is a multifactorial disease. Repetitive cumulative damage of cellular organelles by oxy-free radicals are few of the important causative factors. Aim : To assess the role of oxidative stress in the laryngeal cancer patients in Indian population. Setting and Design : Case control study. Materials and Methods : Level of malondialdehyde (MDA) as a marker of oxidative stress was examined in large cohort of control (50) and laryngeal carcinoma patients (155) from North India. Both the controls and laryngeal carcinoma patients were smokers. Results : In control healthy subjects MDA levels were 0.102±0.07 (0.080- 0.303, 95% CI) n mol/ml, as compared to 0.329±0.16 (0.124-0.354, 95% CI) n mol/ml in the cases of laryngeal carcinoma patients. Three times higher serum MDA levels indicated that there was significant oxidative stress in the subjects having laryngeal carcinoma lesions. In addition patients with secondaries were having MDA levels of 0.4±0.02 (0.391-0.408 95% CI) n mol/ml, as compared to 0.57±0.03 (0.558-0.582 95% CI)n mol/ml in group of patients without secondaries. These two values were statistically significant as compared to control values (P< 0.01). Conclusion : These findings suggest that in case of laryngeal carcinoma patients, there is increase in the level of oxidative enzyme MDA. The oxidative stress might be due to the modulation of pro-oxidant or anti-oxidant systems in laryngeal carcinoma

Serum Level of Antioxidant Vitamins (Vitamin A, C and E) in ,i>Plasmodium falciparum Malaria Infected Children in Owerri, Eastern Nigeria

The levels of antioxidant vitamins were estimated in Plasmodium falciparum malaria infected children. Forty-three children with P.falciparum infection were selected based on the clinicalsymptoms. Twenty-two apparently healthy children with no malaria parasitaemia were included as the control subjects. P.falciparum parasitaemia and serum levels of the antioxidant vitamins (vitamin A,C and E) were determined using standard procedures. It was observed that all parameters measured were significantly lower in malaria infected children when compared with the respective control values. The relationship between malaria parasitaemia and serum concentration of vitamin E were positively correlated (r= 0.42), but vitamin A (r= -0.05) and C (-0.06) were negatively correlated. Children within 0-5 years of age had higher malarial parasitaemia (7379.82 ± 918 99/ìL) than thosebetween 6-12 years of age (5026.19 ± 1514.58/ìL), and these children had lower concentrations of vitamin A (21.27 ± 8.68 ìg/dL), C (0.45 ± 0.19 mg/dl) and E (0.69 ± 0.22 mg/dL) when comparedwith children between 6-12 years (vitamin A = 25.19 ± 8.12 ìg/dL, vitamin C = 0.53 ± 0.16 mg/ dL and vitamin E = 0.86 ± 0.41 mg/ dL). Results suggest that in Owerri, Eastern Nigeria, the degree ofmalaria parasitaemia in especially children between 0-5 years could comprise immunity (as judged by the correlation) and reduce serum antioxidant vitamin levels. Health care providers should recognizethese effects in planning malarial treatment and control programs. Changes in serum antioxidant levels during post-treatment periods should be investigated and documented

Anveshak - A Groundtruth Generation Tool for Foreground Regions of Document Images

We propose a graphical user interface based groundtruth generation tool in this paper. Here, annotation of an input document image is done based on the foreground pixels. Foreground pixels are grouped together with user interaction to form labeling units. These units are then labeled by the user with the user defined labels. The output produced by the tool is an image with an XML file containing its metadata information. This annotated data can be further used in different applications of document image analysis.Comment: Accepted in DAR 201