A Reliable and Cost-Efficient Auto-Scaling System for Web Applications Using Heterogeneous Spot Instances

Cloud providers sell their idle capacity on markets through an auction-like mechanism to increase their return on investment. The instances sold in this way are called spot instances. In spite that spot instances are usually 90% cheaper than on-demand instances, they can be terminated by provider when their bidding prices are lower than market prices. Thus, they are largely used to provision fault-tolerant applications only. In this paper, we explore how to utilize spot instances to provision web applications, which are usually considered availability-critical. The idea is to take advantage of differences in price among various types of spot instances to reach both high availability and significant cost saving. We first propose a fault-tolerant model for web applications provisioned by spot instances. Based on that, we devise novel auto-scaling polices for hourly billed cloud markets. We implemented the proposed model and policies both on a simulation testbed for repeatable validation and Amazon EC2. The experiments on the simulation testbed and the real platform against the benchmarks show that the proposed approach can greatly reduce resource cost and still achieve satisfactory Quality of Service (QoS) in terms of response time and availability

Does participatory water management contribute to smallholder incomes? Evidence from Minle County, Gansu Province, P.R. China

Since the early 1990s, the Chinese water sector has undergone an important institutional reform that has shifted major responsibilities in irrigation management from the government toward water users, organized in so-called Water User Associations (WUAs). Such participatory water management is not only assumed to increase water use efficiency, but also to stimulate the incomes of member households. This study aims to provide empirical evidence of the impact of participatory water management on WUA performance and farmer incomes, using data collected for the year 2007 among 317 households and 35 WUAs in Minle County, Gansu Province. We find that having democratically elected leaders has a positive effect on WUA performance, by increasing investment levels and improving canal quality. Participation in decision making, however, has a significant negative impact on canal quality and does not affect other WUA performance indicators. Two aspects of WUA performance, investment levels and financial health, are found to have a positive impact on the farm income of member households, while water use per mu has a significant negative impact on farm incomes. We find evidence that households belonging to better performing WUAs increase their farm incomes at the expense of non-farm income. The resulting net impact of participatory water management on total household income is not significant for the households in our sample

X-ray Timing Observations of PSR J1930+1852 in the Crab-like SNR G54.1+0.3

We present new X-ray timing and spectral observations of PSR J1930+1852, the young energetic pulsar at the center of the non-thermal supernova remnant G54.1+0.3. Using data obtained with the Rossi X-ray Timing Explorer and Chandra X-ray observatories we have derived an updated timing ephemeris of the 136 ms pulsar spanning 6 years. During this interval, however, the period evolution shows significant variability from the best fit constant spin-down rate of $\dot P = 7.5112(6) \times 10^{-13}$ s s$^{-1}$, suggesting strong timing noise and/or glitch activity. The X-ray emission is highly pulsed ($71\pm5$ modulation) and is characterized by an asymmetric, broad profile ($\sim 70$ duty cycle) which is nearly twice the radio width. The spectrum of the pulsed emission is well fitted with an absorbed power law of photon index $\Gamma = 1.2\pm0.2$; this is marginally harder than that of the unpulsed component. The total 2-10 keV flux of the pulsar is $1.7 \times 10^{-12}$ erg cm$^{-2}$ s$^{-1}$. These results confirm PSR J1930+1852 as a typical Crab-like pulsar.Comment: 14 pages with 7 figures included, accepted to Ap

Hot electrons in low-dimensional phonon systems

A simple bulk model of electron-phonon coupling in metals has been surprisingly successful in explaining experiments on metal films that actually involve surface- or other low-dimensional phonons. However, by an exact application of this standard model to a semi-infinite substrate with a free surface, making use of the actual vibrational modes of the substrate, we show that such agreement is fortuitous, and that the model actually predicts a low-temperature crossover from the familiar T^5 temperature dependence to a stronger T^6 log T scaling. Comparison with existing experiments suggests a widespread breakdown of the standard model of electron-phonon thermalization in metals

Contribution of Fe3O4 nanoparticles to the fouling of ultrafiltration with coagulation pre-treatment

A coagulation (FeCl3)-ultrafiltration process was used to treat two different raw waters with/without the presence of Fe3O4 nanoparticle contaminants. The existence of Fe3O4 nanoparticles in the raw water was found to increase both irreversible and reversible membrane fouling. The transmembrane pressure (TMP) increase was similar in the early stages of the membrane runs for both raw waters, while it increased rapidly after about 15 days in the raw water with Fe3O4 nanoparticles, suggesting the involvement of biological effects. Enhanced microbial activity with the presence of Fe3O4 nanoparticles was evident from the measured concentrations of extracellular polymeric substances (EPS) and deoxyribonucleic acid (DNA), and fluorescence intensities. It is speculated that Fe3O4 nanoparticles accumulated in the cake layer and increased bacterial growth. Associated with the bacterial growth is the production of EPS which enhances the bonding with, and between, the coagulant flocs; EPS together with smaller sizes of the nano-scale primary particles of the Fe3O4-CUF cake layer, led to the formation of a lower porosity, more resilient cake layer and membrane pore blockage

Deducing topology of protein-protein interaction networks from experimentally measured sub-networks.

BackgroundProtein-protein interaction networks are commonly sampled using yeast two hybrid approaches. However, whether topological information reaped from these experimentally-measured sub-networks can be extrapolated to complete protein-protein interaction networks is unclear.ResultsBy analyzing various experimental protein-protein interaction datasets, we found that they are not random samples of the parent networks. Based on the experimental bait-prey behaviors, our computer simulations show that these non-random sampling features may affect the topological information. We tested the hypothesis that a core sub-network exists within the experimentally sampled network that better maintains the topological characteristics of the parent protein-protein interaction network. We developed a method to filter the experimentally sampled network to result in a core sub-network that more accurately reflects the topology of the parent network. These findings have fundamental implications for large-scale protein interaction studies and for our understanding of the behavior of cellular networks.ConclusionThe topological information from experimental measured networks network as is may not be the correct source for topological information about the parent protein-protein interaction network. We define a core sub-network that more accurately reflects the topology of the parent network

Allele-specific expression analysis does not support sex chromosome inactivation on the chicken Z chromosome

Heterogametic sex chromosomes have evolved many times independently, and in many cases the loss of functional genes from the sex-limited Y or W chromosome leaves only one functional gene copy on the corresponding X or Z chromosome in the heterogametic sex. Because gene dose often correlates with gene expression level, this difference in gene dose between males and females for X or Z-linked genes in some cases has selected for chromosome-wide transcriptional dosage compensation mechanisms to counteract any reduction in expression in the heterogametic sex. These mechanisms are thought to restore the balance between sex-linked loci and the autosomal genes they interact with, and this also typically results in equal expression between the sexes. However, dosage compensation in many other species is incomplete, and in the case of birds average expression from males (ZZ) remains higher than in females (ZW). Interestingly, recent reports in chickens and related species have shown that the Z chromosome is expressed less in males than would be expected from two copies of the chromosome, and recent data from cell-based approaches on 11 loci in chicken have suggested that one Z chromosome is partially inactivated in males, in a mechanism thought to be homologous to X inactivation in therian mammals. In the present study, we use controlled crosses in three tissues to test for the presence of Z inactivation in males, which would be expected to bias transcription to the active gene copy (allele-specific expression). We show that for the vast majority of genes on the chicken Z chromosome, males express both parental alleles at statistically similar levels, indicating no Z chromosome inactivation. For those Z chromosome loci with detectable ASE in males, we show that the most likely cause is cis-regulatory variation, rather than Z chromosome inactivation. Taken together, our results indicate that unlike the X chromosome in mammals, Z inactivation does not affect an appreciable number of loci in chicken