2,266 research outputs found
Heavy-Flavor production and spectroscopy at CMS
A representative sample of recent CMS measurements in Heavy-
Flavor physics, based on proton-proton collision data collected in 2011 at a center-ofmass energy of 7TeV, are reviewed. Particular emphasis is given to exotic quarkonia,
properties of b-hadrons and observation of new hadrons
Multidimensional prognostic index and mortality in intermediate care facilities: A retrospective study
Multidimensional prognostic index (MPI) is a frailty assessment tool used for stratifying prognosis in older hospitalized people, but data regarding older people admitted to intermediate care facilities (ICFs) are missing. The aim of this study is to evaluate whether MPI can predict mortality in older patients admitted to the ICFs. MPI was calculated using different domains explored by a standard comprehensive geriatric assessment and categorized into tertiles (MPI-1 †0.20, MPI 2 0.20â0.34, MPI 3 > 0.34). A Coxâs regression analysis, taking mortality as the outcome, was used, reporting the results as hazard ratios (HRs) with 95% confidence intervals (CIs). In total, 653 older patients were enrolled (mean age: 82 years, 59.1% females). Patients in MPI-2 (HR = 3.66; 95%CI: 2.45â5.47) and MPI-3 (HR = 6.22; 95%CI: 4.22â9.16) experienced a higher risk of mortality, compared to MPI-1. The accuracy of MPI in predicting mortality was good (area under the curve (AUC) = 0.74, 95%CI: 0.70â0.78). In conclusion, our study showed that prognostic stratification, as assessed by the MPI, was associated with a significantly different risk of mortality in older patients admitted to the ICFs, indicating the necessity of using a CGA-based tool for better managing older people in this setting as well. © 2021 by the authors. Licensee MDPI, Basel, Switzerland
Mortality attributable to COVID-19 in nursing home residents: a retrospective study
Aim: Coronavirus-19 disease (COVID-19) is a widespread condition in nursing home (NH). It is not known whether COVID-19 is associated with a higher risk of death than residents without COVID-19. Therefore, the aim of this study was to assess whether COVID-19 is associated with a higher mortality rate in NH residents, considering frailty status assessed with the Multidimensional Prognostic Index (MPI). Methods: In this retrospective study, made in 31 NHs in Venice, Italy, the presence of COVID-19 was ascertained with a nasopharyngeal swab. Frailty was evaluated using the MPI, modified according to the tools commonly used in our NHs. A Coxâs regression analysis was used reporting the results as hazard ratios (HRs) with 95% confidence intervals (CIs), using COVID-19 as exposure and mortality as outcome and stratified by MPI tertiles. Similar analyses were run using MPI tertiles as exposure. Results: Overall, 3946 NH residents (median age = 87 years, females: 73.9%) were eligible, with 1136 COVID-19 +. During a median follow-up of 275 days, higher values of MPI, indicating frailer people, were associated with an increased risk of mortality. The incidence of mortality in COVID-19 + was more than doubled than COVID-19- either in MPI-1, MPI-2 and MPI-3 groups. The presence of COVID-19 increased the risk of death (HR = 1.85; 95% CI 1.59â2.15), also in the propensity score model using MPI as confounder (HR = 2.48; 95% CI 2.10â2.93). Conclusion: In this retrospective study of NH residents, COVID-19 was associated with a higher risk of all-cause mortality than those not affected by COVID-19 also considering the different grades of frailty. © 2021, The Author(s)
Aspectos econÎmico-produtivos da atividade leiteira em sistemas de produção de base familiar na região noroeste do Rio Grande do Sul.
A RegiĂŁo Noroeste do Rio Grande do Sul representa um importante pĂłlo de produção leiteira e, a qual estĂĄ, em grande parte, baseada em unidades familiares. Assim, o objetivo deste trabalho foi caracterizar, analisar e discutir aspectos econĂŽmico-produtivos desses sistemas de produção, com enfoque na pecuĂĄria leiteira. Interagindo com as famĂlias de agricultores participantes do Programa Rede Leite, tem-se acompanhado vĂĄrias unidades produtivas, observando e realizando registros. Nesse estudo, analisaram-se dados provenientes de 29 propriedades, caracterizadas por 18 indicadores econĂŽmico-produtivos, utilizando-se como ferramenta a estatĂstica multivariada. Identificou-se a formação de dois tipos bĂĄsicos de sistemas de produção, diferenciados principalmente pela ĂĄrea total da propriedade, que, por sua vez, condiciona diferenças em outras variĂĄveis. Os agricultores dispĂ”em de variadas estratĂ©gias produtivas em função das condiçÔes e recursos prĂłprios do sistema. A identificação e caracterização dos tipos de sistemas de produção nos permitem gerar proposiçÔes no sentido de melhorar os processos produtivos e conferir maior sustentabilidade
Total dose effects on deep-submicron SOI technology for Monolithic Pixel Sensor development
We developed and characterized Monolithic pixel detectors in deep-submicron Fully Depleted (FD) Silicon On Insulator (SOI) technology. This paper presents the first studies of total dose effects from ionizing radiation performed on single transistor test structures. This work shows how the substrate bias condition during irradiation heavily affects the resulting radiation damage
Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway (vol 6, 2018)
This corrects the article DOI: 10.1038/srep18785
Improvement of diaphragmatic performance through orthotopic application of decellularized extracellular matrix patch.
AbstractMuscle tissue engineering can provide support to large congenital skeletal muscle defects using scaffolds able to allow cell migration, proliferation and differentiation. Acellular extracellular matrix (ECM) scaffold can generate a positive inflammatory response through the activation of anti-inflammatory T-cell populations and M2 polarized macrophages that together lead to a local pro-regenerative environment. This immunoregulatory effect is maintained when acellular matrices are transplanted in a xenogeneic setting, but it remains unclear whether it can be therapeutic in a model of muscle diseases. We demonstrated here for the first time that orthotopic transplantation of a decellularized diaphragmatic muscle from wild animals promoted tissue functional recovery in an established atrophic mouse model. In particular, ECM supported a local immunoresponse activating a pro-regenerative environment and stimulating host muscle progenitor cell activation and migration. These results indicate that acellular scaffolds may represent a suitable regenerative medicine option for improving performance of diseased muscles
Dry acellular oesophageal matrix prepared by supercritical carbon dioxide
The research leading to these results received funding from Cassa di Risparmio di Trento e Rovereto (CaRiTRo) within the research project âSupercritical decellularization of engineered tissues for clinical applicationâ, biomedical science section, 2013. PDC is supported by NIHR Professorship and the Catapult Cell Therapy, UK. NMP is supported by the European Research Council (ERC StG Ideas 2011 BIHSNAM no. 279985 on âBio-Inspired hierarchical super-nanomaterialsâ, ERC PoC 2013 KNOTOUGH no. 632277 on âSuper-tough knotted fibresâ, ERC PoC 2015 SILKENE no. 693670 on âBionic silk with graphene or other nanomaterials spun by silkwormsâ) and by the European Commission under the Graphene Flagship (WP14 âPolymer Compositesâ, no. 696656). NE thanks Lorenza Lazzari for the donation of BM-MSCs from the Cell Factory Bank (Milan-Italy)
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