Problem drinking and associated factors in older adults in South Africa

Objective: Alcohol abuse poses special risks for increased morbidity and mortality among older adults. Little attention has focused on assessing alcohol use and associated factors among older adults in transitional societies such as South Africa. This study aimed to determine the prevalence of alcohol use and associated factors in older South Africans who participated in the Study of Global Ageing and Adults Health (SAGE) in 2008. Method: We conducted a national population-based cross-sectional study with a sample of 3840 aged 50 years or older in South Africa in 2008. In this study we analysed data from all 2144 participants who were over 60 years old. The questionnaire included socio-demographic characteristics, alcohol intake as well as comorbidity. Risky drinking was defined in two ways: heavy drinkers (>7 drinks/week) and binge drinkers (>3 drinks/one occasion/week).Results: Four percent of participants reported heavy drinking and 3.7% binge drinking. Male gender (Odds Ratio (OR) =3.79, Confidence Interval (CI) =1.38-10.37) and white population group (OR=3.01, CI=1.31-6.89) were associated with risky drinking in multivariate analysis; as well as tobacco use (OR=5.25, CI=2.20-12.52) and not being obese (OR=0.14, CI=0.05-0.35). Hypertension, diabetes and depression were not associated. Conclusion: This study reveals moderate rates of risky drinking among older adults (60 years and more) in South Africa that puts them at risk of morbidity. Alcohol problems among older adults are commonly under-recognized, indicating a need for health care worker intervention.Keywords: Alcohol abuse; Prevalence; Risk factors; Older adults; South Afric

Perceived HIV/AIDS impact among staff in tertiary institutions in the Eastern Cape, South Africa

A descriptive questionnaire-based study was undertaken among staff in tertiary institutions in the Eastern Cape Province.The objective of the study was to explore perceived HIV/AIDS impact on duties at work, staff morale, job satisfaction and workload among a proportionate sample of 872 employees in eight randomly selected tertiary institutions.The results of the study showed that HIV/AIDS impacts negatively on duties at work, lowers staff morale and increases staff workload. Keywords: HIV,AIDS, impact, tertiary institutions, South Africa.R&#201SUM&#201Une &#233tude bas&#233e sur un questionnaire descriptif a &#233t&#233 faite parmi le personnel des &#233tablissements d&#39enseignement sup&#233rieur de la province du Cap de l&#39Est. Le but de cette &#233tude fut d&#39&#233tudier l&#39impact du VIH/SIDA perçu sur les fonctions &#224 remplir dans le lieu de travail, le moral du personnel, la satisfaction professionnelle et la charge de travail parmi un &#233chantillon proportionnel de 872 employ&#233s de huit &#233tablissements s&#233lectionn&#233s au hasard. Les r&#233sultats de cette &#233tude ont montr&#233 que le VIH/SIDA a un impact n&#233gatif sur les fonctions &#224 remplir dans le lieu de travail, qu'il r&#233duit le moral du personnel et qu&#39il augmente la charge de travail. Mots cl&#233s: VIH, SIDA, impact, &#233tablissements d&#39enseignement sup&#233rieur, l&#39Afrique du Sud. Journal of Social Aspects of HIV/AIDS, Vol 2(2) 2005: 277-28

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling

The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway. TNF signaling can result in different biological outcomes including gene activation and cell death induction in the form of apoptosis or necroptosis. RIPK1 is believed to be crucial for regulating the balance between these opposing outcomes. It is therefore not surprising that RIPK1 is highly regulated, most notably by phosphorylation, ubiquitination, and their respective reversals. In this review, we discuss the biological functions of RIPK1 within the context of TNFR1 signaling. Finally, we discuss recent advances in the knowledge on three ubiquitin E3 ligases that exert regulatory functions on RIPK1 signaling: cIAP1, cIAP2, and LUBAC

Examining the impact of HIV&AIDS on South African educators

Our aim in this study was to examine the impact of HIV&AIDS on South African educators. A cross-sectional survey was conducted in public schools combining HIV testing and a face-to-face interview with participants from a nationally representative sample of public educators. The results show that HIV is highly prevalent among South African public educators (12.7%) and the educators who are absent from school for longer periods (20 days or more) compared with those who are absent for less than four days have higher HIV prevalence (16.8% vs 11.95%). Educators also spend time away from teaching while they attend funerals for colleagues who have died (6.7%), for family members (13.4%) and for members of their communities (47.6%). This makes them feel depressed (71%). These results suggest that HIV&AIDS has an impact on the quality of education. There is a need to prevent new HIV infections and reduce morbidity through the implementation of comprehensive integrated prevention and treatment programmes targeted at educators. There is also a need to support educators in coping with the problem of HIV&AIDS at work and in the community

Assessing missed opportunities for the prevention of mother-to-child HIV transmission in an Eastern Cape local service area

Background. Prevention of new HIV infections is a critical imperative for South Africa; the prevention of mother-to-child transmission (PMTCT) is one of the most efficacious HIV prevention interventions.Objective. Assessment of a PMTCT programme to determine missed opportunities.Setting. The Kouga local service area (LSA), bordering Nelson Mandela Bay Municipality (Port Elizabeth) in the Eastern Cape.Methods. An assessment was conducted in 2007 before implementing technical support for strengthening the PMTCT programme, including: interviews with 20 PMTCT managers, 4 maternity staff and 27 other health workers on service provision, management, infrastructure, human resources and the health information system; 296 antenatal clinic users on their service perceptions; 70 HIV-positive women onHIV knowledge, infant feeding, coping, support and service perceptions; 8 representatives from community organisations and 101 traditional health practitioners (THPs). Observations were conducted during site visits to health facilities, and the District Health Information System (DHIS) data were reviewed.Results. Staff had high levels of awareness of HIV policies and most had received some relevant training. Nevirapine uptake varied by clinic, with an average of 56%. There were many missed opportunities for PMTCT, with 67% of pregnant women tested for HIV and only 43% of antenatal care attendees tested during a previous pregnancy. Only 6% of HIV-positive women reported support group participation.Conclusions. Reducing missed opportunities for PMTCT requires strengthening of the formal health sector, intersectoral liaison, and greater community support. Priority areas that require strengthening in the formal health sector include HIV counselling and testing; family planning and nutrition counselling; infant follow-up; human resources; and monitoring and evaluation

Piezo-Polymer-Composite Unimorph Actuators for Active Cancellation of Flow Instabilities Across Airfoils

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.This article presents a smart device for active cancellation of flow instabilities. An array of two piezo unimorph actuators fabricated in piezo-polymer-composite technology is combined with a thin silicone membrane to mimic a movable wall with a closed surface. By locally displacing the thin membrane, a surface wave is generated that interferes with naturally occurring flow instabilities within the boundary layer of an airfoil. Using flow sensors and an intelligent control enables a destructive interference and therefore, an attenuation of natural flow instabilities. This leads to a delay of transition. The boundary layer remains laminar which means drag is reduced. Within the next pages, the setup of the device with actuators, membrane, sensors, and control is introduced. The main focus of this article is on actuator design, modeling, and implementation for wind tunnel experiments. Results of actuator characterization are presented. The non-linear behavior of the piezoactuator (harmonic distortions and impact of high electric fields) is investigated in detail. This study concludes with the results obtained in wind tunnel experiments which prove the functionality of the presented approach. A maximal attenuation of natural occurring flow instabilities of 80% is achieved.DFG, SPP 1207, Strömungsbeeinflussung in der Natur und Techni

Prevalence, circumstances and consequences of non-fatal road traffi c injuries and other bodily injuries among older people in China, Ghana, India, Mexico, Russia and South Africa

Unintentional injuries are one of the main contributors to mortality and disability in elderly populations in low- and middle-income countries. The aim of this study was to examine the annual road traffic and other bodily (not including falls) injury prevalence and associated risk factors among older adults across six lower and upper middle-income countries. A cross- sectional survey involving face-to-face household interviews were conducted in China (n=13,177), Ghana (n=4305), India (n=6560), Mexico (n=2318), the Russian Federation (n=3938) and South Africa (n=3840), resulting in population-based cohorts of persons aged 50+ years.  Measures included questions on injury, self-rated visual difficulties, alcohol use, depression treatment, sleeping problems, self-reported health status, and vision assessment using LogMAR (logarithm of Minimum Angle of Resolution) eye charts. It comprises rows of letters and is used to measure visual acuity. Results indicate that the overall annual non-fatal road traffic injury prevalence was 2.0% and for other bodily injury 2.1% (not including falls) across the six countries. The multivariate logistic regression analysis found that residing in a rural area, taking medications or other treatment for depression in the past 12 months and having a sleeping problem were associated with road traffic injury, while younger age, residing in a rural area, hazardous or harmful alcohol use and having a sleeping problem were associated with other bodily injury. Visual impairment was not associated with prevalence of road traffic injuries. This study provides the burden of non-fatal road traffic injury and other bodily injury and their associated risk factors across the six countries’ studies. The findings of this study improves the understanding of non-fatal road traffic injury and other bodily injury upon which policy makers, programme developers and researchers in public health can design strategic interventions to reduce these preventable injuries as well as improve safety associated with unintentional injuries.Keywords: injury, traffic, ageing, China, Ghana, India, Mexico, Russian Federation, South Africa

Gas hydrate measurements at Hydrate Ridge using Raman spectroscopy

Author Posting. © Elsevier B.V., 2007. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Geochimica et Cosmochimica Acta 71: 2947-2959, doi:10.1016/j.gca.2007.03.032.Oceanic gas hydrates have been measured near the seafloor for the first time using a seagoing Raman spectrometer at Hydrate Ridge, Oregon, where extensive layers of hydrates have been found to occur near the seafloor. All of the hydrates analyzed were liberated from the upper meter of the sediment column near active gas venting sites in water depths of 770-780 m. Hydrate properties, such as structure and composition, were measured with significantly less disturbance to the sample than would be realized with core recovery. The natural hydrates measured were sI, with methane as the predominant guest component, and minor/trace amounts of hydrogen sulfide present in three of the twelve samples measured. Methane large-to-small cage occupancy ratios of the hydrates varied from 1.01 to 1.30, in good agreement with measurements of laboratory synthesized and recovered natural hydrates. Although the samples visually appeared to be solid, varying quantities of free methane gas were detected, indicating the presence of occluded gas a hydrate bubble fabric and/or partial hydrate dissociation in the under-saturated seawater.This work was supported through National Undersea Research Program grant UAF03-0098. DORISS and PUP development was funded by a grant to MBARI from the David and Lucile Packard Foundation

Increasing plant diversity does not influence productivity: empirical evidence and potential mechanisms

The relationship between species diversity and ecosystem functions has generated considerable debate among ecologists. Ecosystem functions (e.g. productivity, nutrient retention) are often positively correlated with species richness in experimental plant assemblages, but little or no correlation exists in natural communities.We examined the effects of species richness on productivity and available soil nitrate by experimentally manipulating richness using random draws from a pool of ten perennial grasses. Species richness had no significant effect on aboveground productivity or soil nitrate availability, suggesting that functional diversity may be more important than species richness in determining ecosystem functions. The relationship between diversity and ecosystem functions may also depend on resource limitation. A positive relationship is expected when below-ground resources are limiting, but the relationship is expected to weaken when below-ground resource supply rates are higher and competition for light becomes more important. Further experiments are required to determine the mechanisms underlying diversity-productivity relationships