权重连接神经网络的光电实现

在Ｈｏｐｆｉｅｌｄ模型基础上，对具有权重连接的Ｈｏｐｆｉｅｌｄ模型引入连接权重矩阵，这样只要在Ｈｏｐｆｉｅｌｄ内容寻址记忆光电阵列前多加一个连接权重矩阵阵列，则得具有权重连接的神经网络模型的光电实现

Association between the rs6950982 polymorphism near the SERPINE1 gene and blood pressure and lipid parameters in a high-cardiovascular-risk population: interaction with Mediterranean diet

The SERPINE1 (serpin peptidase inhibitor, clade E, member 1) gene, better known by its previous symbol PAI-1 (plasminogen activator inhibitor 1), has been associated with cardiovascular phenotypes with differing results. Our aim was to examine the association between the rs6950982 (G > A) near the SERPINE1 gene, blood pressure (BP) and plasma lipid concentrations as well as the modulation of the polymorphism effects by adherence to Mediterranean diet (AMD). We studied 945 high-cardiovascular-risk subjects. Biochemical, clinical, dietary and genetic data (rs6950982) were obtained. We also determined the common rs1799768 (4G/5G), for checking independent effects. AMD was measured by a validated questionnaire, and four groups were considered. rs6950982 (A > G) and rs1799768 (4G/5G) were only in moderate–low linkage disequilibrium (D′ = 0.719; r2 = 0.167). The most significant associations we obtained were with rs6950982 (A > G). In males, the G allele was nominally associated with higher diastolic BP (AA: 81.5 ± 10.9, AG: 82.1 ± 11.4, GG: 85.7 ± 10.5 mmHg; Padditive = 0.030) and systolic BP (AA + AG: 141.4 ± 6.9 mmHg vs. GG: 149.8 ± 8.0 mmHg; Precessive = 0.036). In the whole population, the rs6950982 was also associated with plasma lipids. Subject with the G allele presented higher total cholesterol (Padditive = 0.016, Precessive = 0.011), low-density lipoprotein cholesterol (Padditive = 0.032, Precessive = 0.031) and triglycerides (Padditive = 0.040, Precessive = 0.029). AMD modulated the effect of rs6950982 on triglyceride concentrations (P for interaction = 0.036). Greater AMD reduced the higher triglyceride concentrations in GG subjects. No significant interactions were found for the other parameters. The rs6950982 was associated with higher BP in men and higher triglycerides in the whole population, this association being modulated by AMD

Low HDL Cholesterol, Smoking and IL-13 R130Q Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study

This study was carried out in Greek Cypriot males to identify risk factors that predispose to myocardial infarction (MI). Genetic and lipid risk factors were investigated for the first time in a Greek Cypriot male case-control study.Contrary to other studies, mean low density lipoprotein cholesterol did not differ between cases and controls. High density lipoprotein cholesterol on the other hand, although within normal range in cases and controls, was significantly higher in the control population. In agreement with many other studies, smoking was significantly more prevalent in cases compared with controls. In pooled cases and controls, smokers had a significantly lower HDL-C level compared with non-smokers. The frequency of the IL-13 R130Q homozygotes for the mutation (QQ), as well as the mutant allele were significantly higher in cases compared with controls. The IL-13 R130Q variant, or another locus, linked to it, may increase the risk of MI

The incidence, determinants and outcomes of coronary perforation during percutaneous coronary intervention in the United Kingdom between 2006–2013: an analysis of 527,121 cases from the British Cardiovascular Intervention Society database

Background: As coronary perforation (CP) is a rare but serious complication of percutaneous coronary intervention (PCI) the current evidence base is limited to small series. Using a national PCI database the incidence, predictors and outcomes of CP as a complication of PCI were defined. Methods and Results: Data were prospectively collected and retrospectively analysed from the British Cardiovascular Intervention Society dataset on all PCI procedures performed in England and Wales between 2006 and 2013. Multivariable logistic regressions and propensity scores were used to identify predictors of CP and its association with outcomes. In total 1,762 coronary perforations were recorded from 527,121 PCI procedures (incidence of 0.33%). Patients with CP were more often female or older, with a greater burden of co-morbidity and underwent more complex PCI procedures. Factors predictive of CP included age per year (odds ratio (OR) 1.03, 95% CI 1.02-1.03, p<0.001), previous CABG (OR 1.44, 1.17-1.77, p<0.001), left main (OR 1.54, 1.21-1.96, p<0.001) use of rotational atherectomy (OR 2.37, 1.80-3.11, p<0.001) and CTO intervention (OR 3.96, 3.28-4.78, p<0.001). Adjusted odds of adverse outcomes were higher for all major adverse coronary events including stroke, bleeding and mortality. Emergency surgery was required in 3% of cases. Predictors of mortality in patients with CP included age, diabetes, previous myocardial infarction, renal disease, ventilatory support, use of circulatory support, glycoprotein inhibitor use and stent type. Conclusions: Using a national PCI database for the first time the incidence, predictors and outcomes of coronary perforation were defined. Although CP as a complication of PCI occurred rarely, it was strongly associated with poor outcomes

Meta-analysis of Percutaneous Coronary Intervention with Drug Eluting Stent Versus Coronary Artery Bypass Grafting for Isolated Proximal Left Anterior Descending Coronary Disease

We performed a meta-analysis of the studies comparing the efficacy and safety of coronary artery bypass surgery (CABG) against percutaneous coronary intervention with drug-eluting stents (PCI-DES) among patients with isolated LAD disease. Due to limited randomised trial data the optimal revascularisation strategy for patients with isolated LAD disease remains uncertain. Using MEDLINE and EMBASE to source data 11 articles (3 randomized trials and 8 cohort studies) including 5,044 participants were identified. No significant difference in mortality between PCI-DES to CABG (111/2,122 (5.2%) and 120/2,574 (4.7%); RR 1.23;95%CI 0.90-1.69) was detected. For MACE, PCI-DES was associated with significant increase in adverse events (RR 1.41;95%CI 1.03-1.93, 8 studies, 4,230 participants). There were no significant differences in the risk of myocardial infarction (RR 0.86;95%CI 0.58-1.26) or stroke (RR 2.36;95%CI 0.54-10.43) between the two groups. There were 239 TVR events among 2,237 participants in the PCI-DES group (10.7%), and 145 TVR events among 2,793 participants in the CABG group (5.2%) with a significant increase risk of TVR in the PCI group (RR 2.52;95%CI 1.69-3.77, 5,030 participants) compared to CABG. In conclusion, for patients with isolated disease of the LAD, meta-analysis of the available data suggests revascularization with a PCI-DES strategy offers similar mortality, MI and stroke rates to CABG at the expense of increased TVR. Much of the data is derived from registries using first generation DES and further randomized trials with more contemporary platforms are needed