Multi-dimensional parametric assessment with IoT in acquaintance of digital pipeline

In IoT researches are found millions of devices are connected in global digital infrastructure framed in network fashion. Most of the things on the network use cloud or central database to share their data and control signals to control and manage the devices on the IoT network. Devices on the network need fast traversing paths, to take correct decision in right time. The data synchronization between source and destination is very important in real time parameter maintenance. The multidimensional parametric evaluation of the environment or the surrounding area is facing problems with data synchronization and congestion in the sensor network. This will lead arrival of fault data at the destination. The fault data also leads a misconception at user end. In the present work pipeline integration is proposed to overcome the misconception and synchronization failures. The pipeline and Arduino UNO processor are integrated on Proteus simulation tool. Transducer nodes and the functionalities are analysed with pipeline

METHOD DEVELOPMENT AND VALIDATION STUDY FOR QUANTITATIVE DETERMINATION OF GENOTOXIC IMPURITY AND ITS PRECURSOR IN FLUCONAZOLE SAMPLE BY LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY

Objective: The objective of this work is method development and validation study for quantitative determination of 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole, a genotoxic impurity and its precursor in a fluconazole drug sample by liquid chromatography–tandem mass spectrometry.Methods: LC-MS/MS analysis of these impurities was performed on Hypersil BDS C18 (100 mm x 4.0 mm, 3 µm) column. 5 mmol ammonium acetate and acetonitrile in the ratio of 65:35 (v/v) was used as the mobile phase with a flow rate of 0.4 ml/min. The developed method was accomplished with a short run time of 10 min. Triple quadrupole mass detector coupled with positive electrospray ionization was used for the quantification of genotoxic impurities in multiple reaction monitoring (MRM).Results: The method was validated as per International Conference on Harmonization (ICH) guidelines. The method was linear in the range of 0.30 µg/g to 11.37 µg/g for impurity A and 0.30 µg/g to 11.34 µg/g for impurity B with a correlation coefficient of 0.999. The accuracy of the method was in the range of 98.25 % to 100.53 % for both impurities.Conclusion: A specific, selective, highly sensitive and more accurate analytical method using LC-MS/MS coupled with positive electrospray ionization has been developed for the quantification of genotoxic impurity (1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole) and its precursor (1-(2,4-difluorophenyl)-2-[1,2,4]triazol-1-yl-ethanone) at 0.3 µg/g with respect to the 5.0 mg/ml of fluconazole

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Not AvailableIt is reported that about 41 compounds are found in substantial quantities to enable the smoker to perceive their impact on smoke flavour. With the objective of analysing neutral volatile compounds responsible for smoke flavour in FCV tobacco grown in Northern Light Soils (NLS), Karnataka Light Soils (KLS) & Southern Light Soils (SLS), steam volatile compounds were extracted and gas chromatography- mass spectrometry (GC-MS) analysis was carried out. As authentic standards of the compounds are not available for quantification, the area normalization method was adopted and the proportion of a particular compound in the total neutral volatile fraction was calculated. Composition of the neutral volatile fraction varied in tobacco samples from different agro-climatic zones. Higher proportion of neophytadiene (40.8%), megastigmatrienone isomers (10.1%), thunbergol (7.2%), 3- hydroxysolavetivone (6.7%), solavetivone (4.6%) and duvatriendiol (4.1%) was observed in NLS samples. Neophytadiene (21.0%), dibutyl phthalate (21.5%), viridiflorol (13.9%), 3-hydroxysolavetivone (12.3%), 1-nonadecene (12.0%), thunbergol (11.3%), solavetivone (8.1%), cembrene (6.3%) and megastigmatrienone isomers (5.9%) were the important compounds in the fraction in KLS samples. These differences could be attributed to the climatic conditions and agronomic practices, the variety Kanchan being common. In the samples from SLS region, the proportion of neophytadiene (28.4%), thunbergol (23.5%), viridiflorol (17.2%), caryophyllene oxide (9.6%), duvatrienediol (9.2%) and megastigmatrienone isomers (8.9%) was high, thus implying the varietal effect, as Hema and Siri are predominantly cultivated in the region. Identification of compounds viz., rishitin, solavetivone, nerolidol, farnesol and linalool necessitates further investigations on their role in insect-pest management.Not Availabl

Application and Analysis of Machine Learning Algorithms on Pima and Early Diabetes Datasets for Diabetes Prediction

Diabetes is a chronic condition that strike how your body burns food for energy. Much of the food you consume is converted by your body into sugar (glucose), which is then released into your bloodstream. Your pancreas releases insulin when your blood sugar levels rise. Over the years, several scholars have sought to create reliable diabetes prediction models. Due to a lack of adequate data sets and prediction techniques, this discipline still faces many unsolved research issues, which forces researchers to apply big data analytics and ML-based methodology. Four distinct machine learning algorithms are used in the study to analyze healthcare prediction analytics and solve the issues. In this investigation, the Pima and Early detection datasets were employed. We applied the Decision Tree, MLP, Naive Bayes, and Random Forest algorithms to these datasets and evaluated the accuracy and F-Measure. The goal of this research is to develop a system that could more precisely predict a patient's risk of developing diabetes

Dynamic hip screw technique in the management of trochanteric fracture

Background: Study was conducted to find the results of dynamic hip screw in the management of trochanteric fracture by analyzing the factors which influence post-operative mobility.Methods: Study was conducted in the department of orthopedics, GSL Medical College. Individuals >18 years, both genders who were diagnosed having trochanteric type I and II Boyd and Griffin stable fractures were included in the study. All surgeries were performed under spinal anesthesia, internal fixation with dynamic hip screw and 135o angled blade plate. Injectable third generation cephalosporins were used 24 hours preoperatively, intra- operatively and 5 days post-operatively, and oral antibiotics till suture removal. Patients allowed to sit on bed on 2nd and 3rd day and static quadriceps exercises were started from 2nd day onwards, hip and knee flexion exercises from 6 or 7th day and weight bearing walking form 10th day.Results: The average age was of the participants was 61.53 years, ranged between 41 to 80 years; 65% were female participants and 35% were male patients. In the study, 20 (50%) patients had right side fracture and left sided affection of trochanteric fracture to the remaining 50%. Most of the patients (67.5%) in this study were classified as type II Boyd and Griffin criteria, and 32.5% were type I. The clinical and functional outcome was calculated using the Kyle's criteria; 25% (10) showed excellent response, followed by good (50%), fair (15%) and poor (10%) results.Conclusions: Dynamic hip screw is the operative treatment of choice for stable trochanteric fractures. However, studies on large sample for long time are recommended

Functional outcome in displaced proximal humeral fractures in adults treated by proximal humeral locking plates

Background: The management of proximal humerus fractures (PHF) is a challenging task to any surgeon. Study was conducted to evaluate the clinical and functional outcome of the proximal humeral internal locking system in fixation of displaced proximal humeral fractures.Methods: Study was conducted in the Department of Orthopedics, GSL Medical College. Informed written consent was taken from the study participants. All skeletally mature patients aged >18 years, presenting with displaced PHF according to Neer two, three and four part fracture were included in the study. Either deltopectoral or deltoid splitting approach was used for surgery, post-operative rehabilitation was started on day one.Results: Twenty-five patients with PHF were enrolled in the study; five-holed proximal humerus locking plate (PHLP) was used for 18 patients, eight-holed PHLP for 05 and three-holed, ten-holed PHLP for 01 for one each. The Constant-Murley score was significantly improved (p=0.000) over each successive follow-up period with the average improvement of around 19 scores between 1st and 2nd follow-up and around 15 score improvement between 2nd and 3rd follow-up.Conclusions: The proximal humeral locking plate is an adequate device for the fixation of displaced two-part, three-part and four-part PHF. Patient can regain good shoulder function, resume normal activities much earlier

Formation constants of binary & ternary chelates of Ln(III) with maltol & kojic acid in presence of amino carboxylic acids

174-175The formation constants of binary and ternary systems involving 3-hydroxy-2-methyl-4-pyrone (HMP) (maltol) and 5-hydroxy-2-hydroxymethyl-4-pyrone (HOMP) (kojic acid), with lanthanide metal ions [La(III), Pr(II), Nd(III), Gd(III), Dy(III) and Y(III)] in the presence of iminodiacetic acid (IMDA), hydroxyethyliminodiacetic acid (HIMDA) and nitrilotriacetic acid (NTA) have been determined in aqueous medium at 30°C and μ = 0.1 M (NaClO4). The order of stabilities of ternary systems is: HMP > HOMP and IMDA > HIMDA > NTA. These are explained in the light of the basi-cities of the Iigands and charge neutralisation