17 research outputs found
A reforma educacional no MĂ©xico e no Chile: apontamentos sobre as rupturas e continuidades
Nutritional psychiatry research: an emerging discipline and its intersection with global urbanization, environmental challenges and the evolutionary mismatch
Homogeneidade e heterogeneidade nos sistemas educacionais: Argentina, Brasil, Chile e MĂ©xico
On the mechanism of Candida tropicalis biofilm reduction by the combined action of naturally-occurring anthraquinones and blue light
Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study
Effect of VIUSID AgroÂź and FitoMas-EÂź on the Ex Vitro Acclimatization of Sugarcane Plants (Saccharum spp.) Cultivar C90-469
Identification of Novel Cyclic Lipopeptides from a Positional Scanning Combinatorial Library with Enhanced Antibacterial and Antibiofilm Activities
Treating bacterial infections can be difficult due to innate or acquired resistance mechanisms, and the formation of biofilms. Cyclic lipopeptides derived from fusaricidin/LI-F natural products represent particularly attractive candidates for the development of new antibacterial and antibiofilm agents, with the potential to meet the challenge of bacterial resistance to antibiotics. A positional-scanning combinatorial approach was used to identify the amino acid residues responsible for driving antibacterial activity, and increase the potency of these cyclic lipopeptides. Screening against the antibiotic resistant ESKAPE pathogens revealed the importance of hydrophobic as well as positively charged amino acid residues for activity of this class of peptides. The improvement in potency was especially evident against bacterial biofilms, since the lead cyclic lipopeptide showed promising in vitro and in vivo anti-biofilm activity at the concentration far below its respective MICs. Importantly, structural changes resulting in a more hydrophobic and positively charged analog did not lead to an increase in toxicity toward human cells