Superform formulation for vector-tensor multiplets in conformal supergravity

The recent papers arXiv:1110.0971 and arXiv:1201.5431 have provided a superfield description for vector-tensor multiplets and their Chern-Simons couplings in 4D N = 2 conformal supergravity. Here we develop a superform formulation for these theories. Furthermore an alternative means of gauging the central charge is given, making use of a deformed vector multiplet, which may be thought of as a variant vector-tensor multiplet. Its Chern-Simons couplings to additional vector multiplets are also constructed. This multiplet together with its Chern-Simons couplings are new results not considered by de Wit et al. in hep-th/9710212.Comment: 28 pages. V2: Typos corrected and references updated; V3: References updated and typo correcte

Orbital decay in the classroom

The objective of this paper is to provide a pedagogical framework for the phenomenon of orbital decay of satellites in low Earth orbit. The dynamics of orbital decay are derived considering atmospheric drag as the only dissipative mechanism and using an educational approach suitable for undergraduate calculus-based physics and engineering courses. The resulting nonlinear first-order differential equation for the altitude as a function of time is solved numerically for the isothermal-barotropic atmospheric model with a fixed scale height. The model is validated using the uncontrolled reentry data of the Chinese space station Tiangong-1

Symplectic structure of N=1 supergravity with anomalies and Chern-Simons terms

The general actions of matter-coupled N=1 supergravity have Peccei-Quinn terms that may violate gauge and supersymmetry invariance. In addition, N=1 supergravity with vector multiplets may also contain generalized Chern-Simons terms. These have often been neglected in the literature despite their importance for gauge and supersymmetry invariance. We clarify the interplay of Peccei-Quinn terms, generalized Chern-Simons terms and quantum anomalies in the context of N=1 supergravity and exhibit conditions that have to be satisfied for their mutual consistency. This extension of the previously known N=1 matter-coupled supergravity actions follows naturally from the embedding of the gauge group into the group of symplectic duality transformations. Our results regarding this extension provide the supersymmetric framework for studies of string compactifications with axionic shift symmetries, generalized Chern-Simons terms and quantum anomalies.Comment: 27 pages; v2: typos corrected; version to be published in Class.Quantum Gra

N=2 supergravity in five dimensions revisited

We construct matter-coupled N=2 supergravity in five dimensions, using the superconformal approach. For the matter sector we take an arbitrary number of vector-, tensor- and hyper-multiplets. By allowing off-diagonal vector-tensor couplings we find more general results than currently known in the literature. Our results provide the appropriate starting point for a systematic search for BPS solutions, and for applications of M-theory compactifications on Calabi-Yau manifolds with fluxes.Comment: 35 pages; v.2: A sign changed in a bilinear fermion term in (5.7

Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis

© 2014, Springer-Verlag Berlin Heidelberg. Opportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these issues, our investigations have focused on novel derivatives of the antifungal antibiotic Nystatin A1, generated by modifications at the amino group of this molecule. The aims of this study were to evaluate the antifungal effectiveness and host cell toxicity of these new compounds using an in vitro model of oral candidosis based on a reconstituted human oral epithelium (RHOE). Initial studies employing broth microdilution, revealed that against planktonic C. albicans, Nystatin A1had lower minimal inhibitory concentration than novel derivatives. However, Nystatin A1was also markedly more toxic against human keratinocyte cells. Interestingly, using live/dead staining to assess C.albicans and tissue cell viability after RHOE infection, Nystatin A1derivatives were more active against Candida with lower toxicity to epithelial cells than the parent drug. Lactate dehydrogenase activity released by the RHOE indicated a fourfold reduction in tissue damage when certain Nystatin derivatives were used compared with Nystatin A1. Furthermore, compared with Nystatin A1, colonisation of the oral epithelium by C. albicans was notably reduced by the new polyenes. In the absence of antifungal agents, confocal laser scanning microscopy showed that C. albicans extensively invaded the RHOE. However, the presence of the novel derivatives greatly reduced or totally prevented this fungal invasion

Measurement of inclusive D*+- and associated dijet cross sections in photoproduction at HERA

Inclusive photoproduction of D*+- mesons has been measured for photon-proton centre-of-mass energies in the range 130 < W < 280 GeV and a photon virtuality Q^2 < 1 GeV^2. The data sample used corresponds to an integrated luminosity of 37 pb^-1. Total and differential cross sections as functions of the D* transverse momentum and pseudorapidity are presented in restricted kinematical regions and the data are compared with next-to-leading order (NLO) perturbative QCD calculations using the "massive charm" and "massless charm" schemes. The measured cross sections are generally above the NLO calculations, in particular in the forward (proton) direction. The large data sample also allows the study of dijet production associated with charm. A significant resolved as well as a direct photon component contribute to the cross section. Leading order QCD Monte Carlo calculations indicate that the resolved contribution arises from a significant charm component in the photon. A massive charm NLO parton level calculation yields lower cross sections compared to the measured results in a kinematic region where the resolved photon contribution is significant.Comment: 32 pages including 6 figure

Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN)-RMS commonly with RAS pathway mutations. RMS express myogenic master transcription factors MYOD and MYOG yet are unable to terminally differentiate. Here, we report that SNAI2 is highly expressed in FN-RMS, is oncogenic, blocks myogenic differentiation, and promotes growth. MYOD activates SNAI2 transcription via super enhancers with striped 3D contact architecture. Genome wide chromatin binding analysis demonstrates that SNAI2 preferentially binds enhancer elements and competes with MYOD at a subset of myogenic enhancers required for terminal differentiation. SNAI2 also suppresses expression of a muscle differentiation program modulated by MYOG, MEF2, and CDKN1A. Further, RAS/MEK-signaling modulates SNAI2 levels and binding to chromatin, suggesting that the differentiation blockade by oncogenic RAS is mediated in part by SNAI2. Thus, an interplay between SNAI2, MYOD, and RAS prevents myogenic differentiation and promotes tumorigenesis

Measurement of Jet Shapes in Photoproduction at HERA

The shape of jets produced in quasi-real photon-proton collisions at centre-of-mass energies in the range $134-277$ GeV has been measured using the hadronic energy flow. The measurement was done with the ZEUS detector at HERA. Jets are identified using a cone algorithm in the $\eta - \phi$ plane with a cone radius of one unit. Measured jet shapes both in inclusive jet and dijet production with transverse energies $E^{jet}_T>14$ GeV are presented. The jet shape broadens as the jet pseudorapidity ($\eta^{jet}$) increases and narrows as $E^{jet}_T$ increases. In dijet photoproduction, the jet shapes have been measured separately for samples dominated by resolved and by direct processes. Leading-logarithm parton-shower Monte Carlo calculations of resolved and direct processes describe well the measured jet shapes except for the inclusive production of jets with high $\eta^{jet}$ and low $E^{jet}_T$. The observed broadening of the jet shape as $\eta^{jet}$ increases is consistent with the predicted increase in the fraction of final state gluon jets.Comment: 29 pages including 9 figure

Angular and Current-Target Correlations in Deep Inelastic Scattering at HERA

Correlations between charged particles in deep inelastic ep scattering have been studied in the Breit frame with the ZEUS detector at HERA using an integrated luminosity of 6.4 pb-1. Short-range correlations are analysed in terms of the angular separation between current-region particles within a cone centred around the virtual photon axis. Long-range correlations between the current and target regions have also been measured. The data support predictions for the scaling behaviour of the angular correlations at high Q2 and for anti-correlations between the current and target regions over a large range in Q2 and in the Bjorken scaling variable x. Analytic QCD calculations and Monte Carlo models correctly describe the trends of the data at high Q2, but show quantitative discrepancies. The data show differences between the correlations in deep inelastic scattering and e+e- annihilation.Comment: 26 pages including 10 figures (submitted to Eur. J. Phys. C