DYNAMICS OF SURFACE EXPRESSION OF TRIGGER RECEPTOR, EXPRESSED BY MYELOID CELLS-1 (TREM-1) ON VARIOUS SUBPOPULATIONS OF MONOCYTES IN EARLY POSTOPERATIVE PERIOD OF DIRECT REVASCULARIZATION OF MYOCARDIUM

We studied surface expression of trigger receptor, expressed by myeloid cells-1 (TREM-1) on various subpopulations of monocytes before direct revascularization of myocardium with artificial blood flow and in early postoperative period. We registered that various expression of TREM-1 on the surface corresponds to subpopulations of monocytes, and the highest level is observed on CD14hiCD16+ monocytes. By the 1st day of postoperative period elevation of surface expression of TREM-1 occurs on all subpopulations of monocytes, testifying to enlargement of their proinflammatory potential

ISOLATION OF GLICOPROTEID FROM THE FIXED RABIES VIRUS, STRAIN «MOSCOW 3253», AND CONSTRUCTING OF DOT-IMMUNOASSAY DIAGNOSTICUM ON ITS BASIS

Described here are the results of glicoproteid isolation from the fixed rabies virus, strain «Moscow 3253», using non-ionic detergent with subsequent chromatographic purification. The obtained antigen was demonstrated to be applicable as immunoreagent for construction of diagnosticum, by means of conjugation with colloid gold nanoparticles. The diagnosticum is meant for detection of specific antibodies in immune sera of horsesproducers, and in the preparation of anti-rabies immunoglobulin, in dot-immunoassay

ИССЛЕДОВАНИЕ ГОЛОВНОГО МОЗГА У ПАЦИЕНТА С САХАРНЫМ ДИАБЕТОМ 1-го ТИПА С ИСПОЛЬЗОВАНИЕМ МЕТОДИК МАГНИТНО-РЕЗОНАНСНОЙ ТОМОГРАФИИ

Type 1 diabetes mellitus (T1DM) is now widely distributed worldwide and in theRussian Federation, it is an important medical and social problem in connection with the development of serious, disabling complications. Some of these complications could make changes in the brain which are accompanied by cognitive impairments that decrease quality of life and worsening disease compensation. The diagnosis of these disorders to date, possible by using modern methods of magnetic resonance imaging, which describe not only the morphological changes of the brain, but also the metabolism of nervous tissue. The study of the brain, namely structural and metabolic manifestations of diabetes, is one of the priority problem of modern medical science.The aim of the study was to evaluate dynamics in the different techniques of magnetic resonance imaging in the diagnosis of brain changes in patients with T1DM.Research methods included physical examination, in accordance with the diagnostic algorithm of patients with T1DM, a neurologist consultation, an assessment of cognitive function, analysis of brain changes using standard magnetic resonance imaging and spectroscopy. Statistical processing was performed using software package R-system. This publication presents a clinical case of a patient with T1DM and severe cognitive impairments are associated with changes in the brain, diagnosed using standard magnetic resonance imaging and spectroscopy. The study shows the positive role of correction of carbohydrate metabolism in improving cognitive function in a patient with T1DM.In addition, the process analysis revealed the absence of dynamic changes in the brain of a patient with T1DM according to standard magnetic resonance imaging. This required the use of additional techniques – magnetic resonance spectroscopy, which revealed changes of metabolism in the thalamus N-acetyl aspartate, choline and creatinine.Сахарный диабет (СД) 1-го типа (СД-1) в настоящее время широко распространен как во всем мире, так и в Российской Федерации, и является важной медико-социальной проблемой в связи с развитием серьезных инвалидизирующих осложнений. К таким осложнениям относятся изменения головного мозга, которые сопровождаются когнитивными нарушениями, значительно снижающими качество жизни и ухудшающими компенсацию заболевания. Диагностика и выявление этих нарушений на сегодняшний день возможны с помощью современных методик магнитно-резонансной томографии (МРТ), которые описывают не только морфологические изменения головного мозга, но и метаболизм нервной ткани. Исследование структурных и метаболических изменений головного мозга на фоне СД является одной из приоритетных задач современной медицинской науки.Цель исследования – оценить изменения головного мозга с помощью различных методик магнитно-резонансной томографии у пациента с СД-1 и когнитивной дисфункцией.Материал и методы. Проведены общеклиническое обследование в соответствии с алгоритмом диагностики больных СД-1, консультация невролога, оценка когнитивной функции, анализ изменений головного мозга с помощью стандартной МРТ и спектроскопии.В данной публикации представлен клинический случай пациента с СД-1 и выраженными когнитивными нарушениями, а также с изменениями головного мозга, диагностированными с помощью стандартной МРТ и спектроскопии.Результаты. Выявлены нарушение углеводного обмена и наличие когнитивной дисфункции у пациента с СД-1. Кроме того, в процессе анализа обнаружены неспецифические изменения головного мозга у пациента с СД-1 по данным стандартной МРТ. Это потребовало использования дополнительной методики – магнитно-резонансной спектроскопии, с помощью которой удалось выявить изменения метаболизма в таламусе N-ацетиласпартата, холина и креатина

Structure of the Students’ Professional Subject Position in Governorate College

The article describes the aspects and the structure of professional subject position of the students of a provincial college; the technological and qualitative changes in training middle managers to work in agricultural production; value-professional component as a basis for the formation of professional subject position

Badania nad właściwościami adsorpcyjnymi i flotacyjnymi odczynników roślinnych w przetwórstwie materiałów ogniotrwałych

The results of experimental studies of the adsorption and flotation characteristics of herbal extracts which are produced from the leaves and stems of widely spread heracleum plant (HSE) and oak bark (OBE) are presented. Depending on flotation conditions – pH, plant extract concentration and the order of modifier and collector addition, the possibility of improvement of the quality of Cu and Au concentrates is discussed and the dominating factors of plant modifiers behavior in flotation process are defined. It was identified that tannin and plant extracts OBE may form stable insoluble complex compounds with Fe (III) on the surface of pyrrhotite and arsenopyrite which help to hydrophilize mineral surface and decrease its floatability under flotation conditions. Experimental results of adsorption studies using UV-spectroscopy and scanning electron microscopy, added by lazer and atomic force microscopy reveales that components of herbal extracts may fix on the surface of sulfide minerals providing the selective hydrophilic coating on their surface. The formation of the new phase of reactant on pyrite surface was identified, which changed greatly initial morphology of sulfide phase. Newly formed phase is characterized by discrete non-uniform distribution. Moreover, the extract forms rather stable coverage on the mineral surface which can’t be clean off by distilled water. The results of flotation tests justify that cheap plant extracts may be used as flotation modifying agents to separate hard-to-beneficiate pairs of sulfide minerals, replacing highly toxic chemical compounds by environmentally safe substances of plant origin.Zaprezentowano wyniki badań eksperymentalnych nad właściwościami adsorpcyjnymi i flotacyjnymi ekstraktów roślinnych pochodzących z liści i łodyg powszechnie występującej rośliny heracleum plant (pol. barszcz; ang. skrót HSE) oraz kory dębu (ang. skrót OBE). W zależności od warunków flotacji – pH, stężenia ekstraktu roślinnego i kolejności dodawania modyfikatora i kolektora, omówiono możliwości podwyższenia jakości koncentratów Cu i Au, oraz określono dominujące cechy w zachowaniu modyfikatorów roślin w procesie flotacyjnym. Ustalono, że tanina i ekstrakty roślin OBE mogą uformować nierozpuszczalne złożone związki z Fe (III) na powierzchni pirotynu i arsenopirytu, co pomaga w hydrofilizacji mineralnej powierzchni i obniża jej flotowalność. Wyniki badań eksperymentalnych nad adsorpcją przy użyciu spektroskopu UV i skaningowej mikroskopii elektronowej wykazały, że składniki ekstraktów ziołowych mogą adsorbować na powierzchni minerałów siarczkowych zapewniając selektywną powłokę hydrofilową. Odkryto powstanie nowej fazy odczynnika na powierzchni pirytu, co w znaczącym stopniu zmienia wstępną morfologię fazy siarczkowej. Nowopowstała faza charakteryzuje się skokowym, nierównomiernym rozkładem. Ponadto, ekstrakt formuje dość stabilną powłokę na powierzchni mineralnej, której nie można zmyć wodą destylowaną. Wyniki testów flotacyjnych udowadniają, że tanie ekstrakty roślinne mogą być użyte jako czynniki modyfikujące flotację do oddzielania niskoopłacalnych minerałów siarczkowych, zamieniając wysokotoksyczne związki chemiczne na bezpieczne dla środowiska substancje pochodzenia roślinnego

Forming of the professional competence of the future teacher in the process of preparation of the master: theoretical analysis of the problem

У статті автори виокремлюють основні завдання освітньої галузі на сучасному етапі, наголошуючи на потребі підготовки висококваліфікованих педагогічних кадрів. Під час навчання в магістратурі формуються професійні риси, якості та вміння, удосконалюється майстерність майбутнього педагога. Метою статті є теоретичне обґрунтування та вивчення ефективності науково-педагогічних умов формування професійної компетентності майбутніх педагогів у процесі магістерської підготовки. Для підвищення якості навчання необхідно реформувати освітній процес вищого навчального закладу, підвищити якість навчання, створити науково-педагогічні умови, які б забезпечили високу ефективність професійної підготовки майбутніх магістрів. Автори стверджують, що особливе місце у навчально-виховному процесі набуває компетентнісний підхід, що дозволяє формувати професійно мобільного фахівця з високим загальним, культурним та професійним рівнем, готового до змін, систематичного самовдосконалення та самореалізації. In the article, the authors singled out the main tasks of the educational branch at the present stage, stressing the need for the training of highly skilled pedagogical staff. It is emphasized that formation of professional competence is one of the priorities of the national education system. The purpose of the article is to substantiate theoretically and to explore the effectiveness of scientific and pedagogical conditions of formation of future teachers’ professional competence. The essence of such concepts as «professional mobility», «professional competence» and «self-development» has been grounded in the article. The authors analyzed scientific psychological, pedagogical and methodological literature concerning the disclosure of these concepts. The article is a consideration of various points of view and scientific positions on the problem of professional competence formation in students at higher educational institutions from the vantage point of the competency-based approach. It presents and generalizes the content of the main notions in the terminological apparatus of the competency-based approach and ways of professional competence formation in students as a result of their professional preparation. The authors argue that a special place in the educational process acquires a competent approach that allows the formation of a professionally mobile specialist with a high general, cultural and professional level, ready for change, systematic self-improvement and self-realization

Personally-oriented models of development of musically gifted children

Introduction. Nowadays, the development of national competitiveness depends on many factors, but the quality of human capital is first of all. One of priority tasks of education system in Russian Federation is search and support of gifted children and teenagers: creation of conditions for their productive education, full upbringing and optimum development of their abilities providing further maximum self-realisation of a person. Today, however, the implementation of these requirements is real only in megalopolises, large regional centers, but not in small cities, which have no sufficient resources and environment conditions, cultivating potential of every gifted child, especially in the case of art talent. The shortage of highly skilled teachers and cultural industry, weak involvement into cultural life (inability to attend concerts, theatrical performances, exhibitions, etc.), very limited access to participation in creative competitions, olympiads, competitions – all this negatively affects motivation engage in art activity and can lead to serious personal crises and waste of talent.The aim of the article was to reveal the content of models of work with musically gifted children, who have certain problems that block their creative development.Methodology and research methods. The research was based on personally-oriented and system-based approaches to education of gifted children. The authors considered the ideas of Russian and foreign researchers about the need for pedagogical support of gifted children, who have problems in general and cultural development. The methods of theoretical analysis of scientific and scientific-methodological resources, comparative analysis of the results of practical activity, generalisation, oral and written survey and modeling were employed.Results and scientific novelty. The most common challenges of the development of gifted children, who live in towns, are revealed: lack of motivation for creativity and further development; a low level of general culture; tense atmosphere in family, which is expressed most often in the inattentive relation of parents to interests and abilities of a child. The specialists of Ural Musical College and children’s art schools of the city of Ekaterinburg and Sverdlovsk region developed and approved the models of social and pedagogical support of gifted children to eliminate the causes of their failures in education. According to the classification of problems in the development of gifted children, three types of personally-oriented models are offered: 1) motivation to creative activity, 2) cultural self-enrichment, 3) conditions for creative development of the child in family. The realisation of each model should be based on close cooperation of staff members of specialised centres (e.g. in musical college) for work with musically gifted children, teachers of children’s music schools, teachers of educational institutions of towns, children and their parents. The most effective activities, contributing to the solution of the formulated tasks of each model, are identified: concert-performing, cultural-educational and analytical (fixation and reflection of the results of creative development).Practical significance. The experimental testing of models proved the efficiency and possibility of complete and partial use of their components in Russian schools in order to manage the process of development of musically gifted pupils