Enabling transition into higher education for students with asperger syndrome

This project report provides an insight into the lives of students with Asperger Syndrome (AS) during their transition into higher education. It details the experiences of eight students with AS. Students were interviewed multiple times at various junctures throughout their first academic year. Although they told stories of everyday disabling barriers, they also shared experiences of academic and social successes. The project was primarily focused on students with AS; however, its findings will hopefully help inform inclusive policy and practice within higher education institutions

Shrinkage Estimation in Multilevel Normal Models

This review traces the evolution of theory that started when Charles Stein in 1955 [In Proc. 3rd Berkeley Sympos. Math. Statist. Probab. I (1956) 197--206, Univ. California Press] showed that using each separate sample mean from $k\ge3$ Normal populations to estimate its own population mean $\mu_i$ can be improved upon uniformly for every possible $\mu=(\mu_1,...,\mu_k)'$. The dominating estimators, referred to here as being "Model-I minimax," can be found by shrinking the sample means toward any constant vector. Admissible minimax shrinkage estimators were derived by Stein and others as posterior means based on a random effects model, "Model-II" here, wherein the $\mu_i$ values have their own distributions. Section 2 centers on Figure 2, which organizes a wide class of priors on the unknown Level-II hyperparameters that have been proved to yield admissible Model-I minimax shrinkage estimators in the "equal variance case." Putting a flat prior on the Level-II variance is unique in this class for its scale-invariance and for its conjugacy, and it induces Stein's harmonic prior (SHP) on $\mu_i$.Comment: Published in at http://dx.doi.org/10.1214/11-STS363 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Bound States in n Dimensions (Especially n = 1 and n = 2)

We stress that in contradiction with what happens in space dimensions $n \geq 3$, there is no strict bound on the number of bound states with the same structure as the semi-classical estimate for large coupling constant and give, in two dimensions, examples of weak potentials with one or infinitely many bound states. We derive bounds for one and two dimensions which have the "right" coupling constant behaviour for large coupling.Comment: Talk given by A. Martin at Les Houches, October 2001, to appear in "Few-Body Problems

Ceramic materials lead to underestimated DNA quantifications : a method for reliable measurements

In the context of investigating cell-material interactions or of material-guided generation of tissues, DNA quantification represents an elective method to precisely assess the number of cells attached or embedded within different substrates. Nonetheless, nucleic acids are known to electrostatically bind to ceramics, a class of materials commonly employed in orthopaedic implants and bone tissue engineering scaffolds. This phenomenon is expected to lead to a relevant underestimation of the DNA amount, resulting in erroneous experimental readouts. The present work aims at *lpar;i) investigating the effects of DNA-ceramic bond occurrence on DNA quantification, and (ii) developing a method to reliably extract and accurately quantify DNA in ceramic-containing specimens. A cell-free model was adopted to study DNA-ceramic binding, highlighting an evident DNA loss (up to 90%) over a wide range of DNA/ceramic ratios (w/w). A phosphate buffer-based (800 mM) enzymatic extraction protocol was developed and its efficacy in terms of reliable DNA extraction and measurement was confirmed with commonly used fluorometric assays, for various ceramic substrates. The proposed buffered DNA extraction technique was validated in a cell-based experiment showing 95% DNA retrieval in a cell seeding experiment, demonstrating a 3.5-fold increase in measured DNA amount as compared to a conventional enzymatic extraction protocol. In conclusion, the proposed phosphate buffer method consistently improves the DNA extraction process assuring unbiased analysis of samples and allowing accurate and sensitive cell number quantification on ceramic containing substrates

Comparison of habitat-based indices of abundance with fishery-independent biomass estimates from bottom trawl surveys

Rockfish species are notoriously difficult to sample with multispecies bottom trawl survey methods. Typically, biomass estimates have high coefficients of variation and can fluctuate outside the bounds of biological reality from year to year. This variation may be due in part to their patchy distribution related to very specific habitat preferences. We successfully modeled the distribution of five commercially important and abundant rockf ish species. A two-stage modeling method (modeling both presence-absence and abundance) and a collection of important habitat variables were used to predict bottom trawl survey catch per unit of effort. The resulting models explained between 22% and 66% of the variation in rockfish distribution. The models were largely driven by depth, local slope, bottom temperature, abundance of coral and sponge, and measures of water column productivity (i.e., phytoplankton and zooplankton). A year-effect in the models was back-transformed and used as an index of the time series of abundance. The abundance index trajectories of three of five species were similar to the existing estimates of their biomass. In the majority of cases the habitat-based indices exhibited less interannual variability and similar precision when compared with stratified survey-based biomass estimates. These indices may provide for stock assessment models a more stable alternative to current biomass estimates produced by the multispecies bottom trawl survey in the Gulf of Alaska

Quantum nature of cosmological bounces

Several examples are known where quantum gravity effects resolve the classical big bang singularity by a bounce. The most detailed analysis has probably occurred for loop quantum cosmology of isotropic models sourced by a free, massless scalar. Once a bounce has been realized under fairly general conditions, the central questions are how strongly quantum it behaves, what influence quantum effects can have on its appearance, and what quantum space-time beyond the bounce may look like. This, then, has to be taken into account for effective equations which describe the evolution properly and can be used for further phenomenological investigations. Here, we provide the first analysis with interacting matter with new effective equations valid for weak self-interactions or small masses. They differ from the free scalar equations by crucial terms and have an important influence on the bounce and the space-time around it. Especially the role of squeezed states, which have often been overlooked in this context, is highlighted. The presence of a bounce is proven for uncorrelated states, but as squeezing is a dynamical property and may change in time, further work is required for a general conclusion.Comment: 26 page

When adolescents stop psychological therapy: rupture-repair in the therapeutic alliance and association with therapy ending

therapeutic alliance consistently predicts dropout from psychological therapy, and ruptures in the therapeutic alliance may also predict dropout, yet there is a dearth of research with adolescents. This study investigated whether markers of rupturerepair in the therapeutic alliance were indicative of different types of treatment ending in adolescents who received psychological treatment for depression. Data were from the IMPACT study, a trial investigating the effectiveness of therapies for adolescent depression. Participants were randomly allocated to receive a psychological therapy: Brief Psychosocial Intervention, Cognitive-Behavioural Therapy or Short-Term Psychoanalytic Psychotherapy. The sample (N=35) comprised adolescents who had either completed their treatment (n=14) or dropped out (n=21) according to their therapist. Dropout cases were further classified as dissatisfied (n=14) or got-whatthey- needed (n=7) based on post-therapy interviews with the adolescent and therapist. Selected audio-recordings of therapy sessions were rated using the Rupture Resolution Rating System and Working Alliance Inventory (observer-version). Therapeutic alliance and rupture-repair during therapy were similar for completers and got-what-they-needed dropouts, while dissatisfied dropouts had poorer therapeutic alliance, more ruptures, ruptures were frequently unresolved, and therapists contributed to ruptures to a greater extent. Qualitative analysis of the sessions led to the construction of three categories of therapist contribution to ruptures: therapist minimal response; persisting with a therapeutic activity; and focus on risk. Results suggest that ruptures, especially when unresolved, could be regarded as warning signs of disengagement and dropout from psychological treatment. Future research should investigate how ruptures may be effectively identified and resolved in treatment with adolescents