Multiple-relaxation-time Finsler-Lagrange dynamics in a compressed Langmuir monolayer

In this paper an information geometric approach has been proposed to describe the two-dimensional (2d) phase transition of the first order in a monomolecular layer (monolayer) of amphiphilic molecules deposited on air/water interface. The structurization of the monolayer was simulated as an entropy evolution of a statistical set of microscopic states with a large number of relaxation times. The electrocapillary forces are considered as information constraints on the statistical manifold. The solution curves of Euler-Lagrange equations and the Jacobi field equations point out contracting pencils of geodesic trajectories on the statistical manifold, which may change into spreading ones, and converse. It was shown that the information geometrodynamics of the first-order phase transition in the Langmuir monolayer finds an appropriate realization within the Finsler-Lagrange framework

Geometrization of the theory of electromagnetic and spinor fields on the background of the Schwarzschild spacetime

The geometrical Kosambi–Cartan–Chern approach has been applied to study the systems of differential equations which arise in quantum-mechanical problems of a particle on the background of non-Euclidean geometry. We calculate the geometrical invariants for the radial system of differential equations arising for electromagnetic and spinor fields on the background of the Schwarzschild spacetime. Because the second invariant is associated with the Jacobi field for geodesics deviation, we analyze its behavior in the vicinity of physically meaningful singular points r = M, ∞. We demonstrate that near the Schwarzschild horizon r = M the Jacobi instability exists and geodesics diverge for both considered problems.The geometrical Kosambi–Cartan–Chern approach has been applied to study the systems of differential equations which arise in quantum-mechanical problems of a particle on the background of non-Euclidean geometry. We calculate the geometrical invariants for the radial system of differential equations arising for electromagnetic and spinor fields on the background of the Schwarzschild spacetime. Because the second invariant is associated with the Jacobi field for geodesics deviation, we analyze its behavior in the vicinity of physically meaningful singular points r = M, ∞. We demonstrate that near the Schwarzschild horizon r = M the Jacobi instability exists and geodesics diverge for both considered problems

Isophots of Zodiacal Light and Its Terrestrial Component

Isophotes of zodiacal light and its terrestrial component due to interplanetary dust in vicinity of earth-moon syste

FORMATION OF INNATE AND ADAPTIVE IMMUNE RESPONSE UNDER THE INFLUENCE OF DIFFERENT FLAVIVIRUS VACCINES

The review examines in a comparative perspective the key moments of formation of innate and adaptive immune responses to different types of current flavivirus vaccines: live attenuated against yellow fever virus and inactivated whole virus against tick-borne encephalitis virus. Particular attention is paid to the ability of these different vaccines, containing exogenous pathogen-associated molecular structures, to stimulate innate immunity. Live attenuated vaccine by infecting several subtypes of dendritic cells activates them through various pattern-recognition receptors, such as Tolland RIG-I-like receptors, which leads to significant production of proinflammatory cytokines, including interferon-α primary mediator of innate antiviral immunity. By simulating natural viral infection, this vaccine quickly spreads over the vascular network, and the dendritic cells, activated by it, migrate to the draining lymph nodes and trigger multiple foci of Tand B-cell activation. Inactivated vaccine stimulates the innate immunity predominantly at the injection site, and for the sufficient activation requires the presence in its composition of an adjuvant (aluminum hydroxide), which effects the formation and activation of inflammasomes, ensuring the formation and secretion of IL-1β and IL-18 that, in turn, trigger a cascade of cellular and humoral innate immune responses. We demonstrated the possibility of involvement in the induction of innate immunity, mediated by the inactivated vaccine, endogenous pathogenassociated molecular patterns (uric acid and host cell DNA), forming at the vaccine injection site. We discuss the triggering of Band T-cell responses by flavivirus vaccines that determine various duration of protection against various pathogens. A single injection of the live vaccine against yellow fever virus induces polyvalent adaptive immune response, including the production of cytotoxic T-lymphocytes, Th1and Th2-cells and neutralizing antibodies, which may persist for up to 40 years after the vaccination. To induce and maintain protective immunity, mediated by the inactivated vaccine against tick-borne encephalitis virus, it is required: triple immunization, which results in the production primarily of neutralizing antibodies, and subsequent booster injections every 3 years. We considered the potential use of the data on immunological mechanisms of action of current vaccines to generate new highly efficient vaccines

Thermodynamics of propionate degradation in methanogenic paddy soil

Propionate is syntrophically degraded in methanogenic paddy soil via a randomizing pathway. To study the thermodynamic conditions of this syntrophy, propionate degradation was measured in the presence of different H2 partial pressures (1-20,000 Pa) using methanogenic soil slurries taken from planted Italian paddy soil. The logarithmic decrease of [1-14C]propionate or [2-14C]propionate was measured during an incubation period of about 2-3 h to determine degradation rate constants (k). The change of the H2 partial pressure was measured during the same period. Values of k decreased with increasing Ha partial pressures (averaged over the incubation period). However, k was still relatively high, although the Gibbs free energy (ΔG) of syntrophic propionate conversion to acetate, bicarbonate and H2 was already strongly endergonic reaching ΔG values of +60 kJ mol-1 propionate. Assuming propionate conversion to acetate plus formate resulted in the same or even higher ΔG values indicating that this degradation pathway was not realistic. We therefore assume that propionate was degraded within microbial aggregates in which syntrophic propionate degraders were shielded from thermodynamically unfavorable H2 by methanogenic bacteria consuming H2. Gibbs free energies for H2 formation from propionate correlated negatively with the ΔG values for H2 conversion to CH4, but the latter values were generally < -5 kJ mol-1 H2 so that methanogenesis from H2 was always possible. Addition of sulfate did not result in a significant decrease of the de values for H2 formation from propionate demonstrating that H2 consumption by sulfate reducers was not relevant during the short incubation period. Nevertheless, propionate degradation was less strongly inhibited by H2 when sulfate was present indicating that propionate was then mainly degraded by sulfate reduction rather than by syntrophy. The major degradation product of [2-14C]propionate was 14C-acetate (followed by 14CO2 and 14CH4) showing that the sulfate reducers oxidized propionate primarily to acetate, bicarbonate and H2. As a conceptual model we therefore speculate that propionate was degraded within methanogenic bacterial aggregates both in the presence and the absence of sulfate and that propionate degraders operated either as sulfate reducers or as H2-producing syntrophs

Analysis of the problems of formation of calligraphic skills in primary school pupils

The article presents the results of a study of calligraphic writing skills in primary school pupils of the general education school and analyzes problems with the acquisition of these skills.В статье представлены результаты исследования каллиграфического навыка письма у обучающихся начальных классов общеобразовательной школы, проведен анализ трудностей овладения данным навыком