1,301 research outputs found
The DiPEP (Diagnosis of PE in Pregnancy) biomarker study: An observational cohort study augmented with additional cases to determine the diagnostic utility of biomarkers for suspected venous thromboembolism during pregnancy and puerperium
This study aimed to estimate the diagnostic utility of biomarkers for suspected venous thromboembolism (VTE) in pregnancy and the puerperium. Research nurses/midwives collected blood samples from 310 pregnant/postpartum women with suspected pulmonary emboli (PE) and 18 with diagnosed deep vein thrombosis (DVT). VTE was diagnosed using imaging, treatment and adverse outcome data. Primary analysis was limited to women with conclusive imaging (36 with VTE, 247 without). The area under the curve (AUC) for each biomarker was: activated partial thromboplastin time 0·669 (95% confidence interval 0·570-0·768), B-type natriuretic peptide 0·549 (0·453-0·645), C-reactive protein 0·542 (0·445-0·639), Clauss fibrinogen 0·589 (0·476-0·701), D-Dimer (by enzyme-linked immunosorbent assay) 0·668 (0·561-0·776), near-patient D-Dimer 0·651 (0·545-0·758), mid-regional pro-atrial natriuretic peptide 0·524 (0·418-0·630), prothrombin fragment 1 + 2 0·562 (0·462-0·661), plasmin-antiplasmin complexes 0·639 (0·536-0·742), prothombin time 0·613 (0·508-0·718), thrombin generation lag time 0·702 (0·598-0·806), thrombin generation endogenous potential 0·559 (0·437-0·681), thrombin generation peak 0·596 (0·478-0·715), thrombin generation time to peak 0·655 (0·541-0·769), soluble tissue factor 0·531 (0·424-0·638) and serum troponin 0·597 (0·499-0·695). No diagnostically useful threshold for diagnosing or ruling out VTE was identified. In pregnancy and the puerperium, conventional and candidate biomarkers have no utility either for their negative or positive predictive value in the diagnosis of VTE
Lyashko-Looijenga morphisms and submaximal factorisations of a Coxeter element
When W is a finite reflection group, the noncrossing partition lattice NCP_W
of type W is a rich combinatorial object, extending the notion of noncrossing
partitions of an n-gon. A formula (for which the only known proofs are
case-by-case) expresses the number of multichains of a given length in NCP_W as
a generalised Fuss-Catalan number, depending on the invariant degrees of W. We
describe how to understand some specifications of this formula in a case-free
way, using an interpretation of the chains of NCP_W as fibers of a
Lyashko-Looijenga covering (LL), constructed from the geometry of the
discriminant hypersurface of W. We study algebraically the map LL, describing
the factorisations of its discriminant and its Jacobian. As byproducts, we
generalise a formula stated by K. Saito for real reflection groups, and we
deduce new enumeration formulas for certain factorisations of a Coxeter element
of W.Comment: 18 pages. Version 2 : corrected typos and improved presentation.
Version 3 : corrected typos, added illustrated example. To appear in Journal
of Algebraic Combinatoric
Interacting Multiple Try Algorithms with Different Proposal Distributions
We propose a new class of interacting Markov chain Monte Carlo (MCMC)
algorithms designed for increasing the efficiency of a modified multiple-try
Metropolis (MTM) algorithm. The extension with respect to the existing MCMC
literature is twofold. The sampler proposed extends the basic MTM algorithm by
allowing different proposal distributions in the multiple-try generation step.
We exploit the structure of the MTM algorithm with different proposal
distributions to naturally introduce an interacting MTM mechanism (IMTM) that
expands the class of population Monte Carlo methods. We show the validity of
the algorithm and discuss the choice of the selection weights and of the
different proposals. We provide numerical studies which show that the new
algorithm can perform better than the basic MTM algorithm and that the
interaction mechanism allows the IMTM to efficiently explore the state space
Financial Time Series Analysis of SV Model by Hybrid Monte Carlo
We apply the hybrid Monte Carlo (HMC) algorithm to the financial time sires
analysis of the stochastic volatility (SV) model for the first time. The HMC
algorithm is used for the Markov chain Monte Carlo (MCMC) update of volatility
variables of the SV model in the Bayesian inference. We compute parameters of
the SV model from the artificial financial data and compare the results from
the HMC algorithm with those from the Metropolis algorithm. We find that the
HMC decorrelates the volatility variables faster than the Metropolis algorithm.
We also make an empirical analysis based on the Yen/Dollar exchange rates.Comment: 8 pages, 3 figures, to be published in LNC
Editorial : The psychology of fake news on social media, who falls for it, who shares it, why, and can we help users detect it?
The proliferation of fake news on social media has become a major societal concern which has been shown to impact elections, referenda, and effective public health messaging (Lewandowsky et al., 2017). To combat this, there is now a growing body of research that focuses on the role of psychological and behavioural science in understanding and mitigating the spread of misinformation (Rapp & Salovich, 2018;Van Bavel et al., 2020). For example, research on belief revision has reported a 'continued influence effect' (CIE) where misinformation lingers in the mind of a person despite being categorically refuted (e.g., Ecker et al., 2010;Desai et al., 2020), simulations have attempted to replicate the seepage of misinformation in social networks (Lewandowsky et al., 2019), and inoculation theorists are building training tools to understand and enhance psychological resistance against misinformation. Such attempts have been conducted in the context of COVID-19 (Basol et al., 2021), political disinformation (Roozenbeek & van der Linden, 2020), and climate change (Maertens et al., 2020). While it is clear that important advances have been made in our understanding of the critical psychological functions that underpin how individuals seek out, process, and share misinformation -there is still much to do. Therefore, in this special topic, we are delighted to introduce six new papers which present novel, interesting, and engaging contributions to our understanding of the fake news phenomenon
Observation of exotic meson production in the reaction at 18 GeV/c
An amplitude analysis of an exclusive sample of 5765 events from the reaction
at 18 GeV/c is described. The
production is dominated by natural parity exchange and by
three partial waves: those with and . A
mass-dependent analysis of the partial-wave amplitudes indicates the production
of the meson as well as the meson, observed for the
first time decaying to . The dominant, exotic
(non- partial wave is shown to be resonant with a mass of
GeV/c^2 and a width of GeV/c^2 . This exotic state, the , is produced with a
dependence which is different from that of the meson, indicating
differences between the production mechanisms for the two states.Comment: 5 pages with 4 figure
Calabi-Yau Duals of Torus Orientifolds
We study a duality that relates the T^6/Z_2 orientifold with N=2 flux to
standard fluxless Calabi-Yau compactifications of type IIA string theory. Using
the duality map, we show that the Calabi-Yau manifolds that arise are abelian
surface (T^4) fibrations over P^1. We compute a variety of properties of these
threefolds, including Hodge numbers, intersection numbers, discrete isometries,
and H_1(X,Z). In addition, we show that S-duality in the orientifold
description becomes T-duality of the abelian surface fibers in the dual
Calabi-Yau description. The analysis is facilitated by the existence of an
explicit Calabi-Yau metric on an open subset of the geometry that becomes an
arbitrarily good approximation to the actual metric (at most points) in the
limit that the fiber is much smaller than the base.Comment: 39 pages; uses harvmac.tex, amssym.tex; v4: minor correction
Partial-wave analysis of the eta pi+ pi- system produced in the reaction pi-p --> eta pi+ pi- n at 18 GeV/c
A partial-wave analysis of 9082 eta pi+ pi- n events produced in the reaction
pi- p --> eta pi+ pi- n at 18.3 GeV/c has been carried out using data from
experiment 852 at Brookhaven National Laboratory. The data are dominated by
J^{PC} = 0^{-+} partial waves consistent with observation of the eta(1295) and
the eta(1440). The mass and width of the eta(1295) were determined to be 1282
+- 5 MeV and 66 +- 13 Mev respectively while the eta(1440) was observed with a
mass of 1404 +- 6 MeV and width of 80 +- 21 MeV. Other partial waves of
importance include the 1++ and the 1+- waves. Results of the partial wave
analysis are combined with results of other experiments to estimate f1(1285)
branching fractions. These values are considerably different from current
values determined without the aid of amplitude analyses.Comment: 22 pages, 8 figure
A partial wave analysis of the system produced in charge exchange collisions
A partial wave analysis of the of the system produced in the
charge exchange reaction: at an incident momentum of
is presented as a function of invariant mass,
, and momentum transfer squared, , from the incident
to the outgoing system.Comment: 24 pages total,8 pages text, 14 figures, 1 table. Submitted to Phys
Rev
Evidence for Exotic J^{PC}=1^{-+} Meson Production in the Reaction pi- p --> eta pi- p at 18 GeV/c
Details of the analysis of the eta pi- system studied in the reaction pi^{-}
p --> eta pi^{-} p at 18 GeV/c are given. Separate analyses for the 2 gamma and
pi+ pi- pi0 decay modes of the eta are presented. An amplitude analysis of the
data indicates the presence of interference between the a(2)(1320)- and a
J^{PC}=1^{-+} wave between 1.2 and 1.6 GeV/c^2. The phase difference between
these waves shows phase motion not attributable solely to the a(2)(1320)-. The
data can be fitted by interference between the a(2)(1320)- and an exotic 1^{-+}
resonance with M = 1370 +-16 +50 -30} MeV/c^2 and Gamma = 385 +- 40 +65 -105
MeV/c^2. Our results are compared with those of other experiments.Comment: 50 pages of text and 34 figure
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