Денежно-кредитная политика в контексте теоретических и методологических проблем экономической науки

The paper focuses on the issue of theoretical and methodological justification of monetary policy and its tools. A review of Russian economists’ theoretical approaches to this problem allowed the authors to identify theoretical, methodological and applied bases of evaluation of monetary policy of the Bank of Russia. The paper presents the authors’ view of the scientific discussion on appropriateness of the monetary policy adopted by the Bank of Russia for the current state of the economy. The authors reveal principle distinctions between theoretical arguments of the supporters of the Bank’s monetary policy and their opponents. The research theoretically and conceptually validates the changes in basic definitions and ideas contributing to the existing understanding of inflation in the monetary policy of the Bank of Russia. The analysis of macroeconomic theory and actual monetary policy gives grounds to conclude about their strong correlation. The suggested review of theoretical approaches to the problem studied will allow determining theoretical, methodological and applied rationale for monetary policy more accurately

The main approaches to the formation socially important qualities of students in social-cultural activities

The article considers the main approaches to the formation of socially significant qualities of students – citizenship, familyship, spirituality, self-development. These qualities will help person to adapt in a constantly changing world and will provide future professional self-confidence, self-sufficiency, the ability to find appropriate solutions to a problems. The proposed model of the formation of these qualities in the studying process of students in a technical University.Рассмотрены основные подходы к формированию социально значимых качеств личности студентов – гражданственности, семейственности, духовности, стремлению к саморазвитию, помогающих человеку адаптироваться в постоянно меняющемся конкурентном мире и обеспечивающих будущему профессионалу уверенность в себе, самодостаточность, умение находить адекватные способы решения проблем. Предложена модель формирования данных качеств в процессе обучения студентов в техническом вузе

Development of probabilistic and statistical models for evaluation of the effectiveness of proppant hydraulic fracturing (on example of the Tl-Bb reservoir of the Batyrbayskoe field)

The main factors affecting the efficiency of proppant hydraulic fracturing of Tl-Bb clastic reservoir depending on various parameters are statistically studied. There are 36 hydraulic fracturing treatments pumped from 2008 to 2016 with an average increase in oil production rate of 8.6 tons per day. Probabilistic statistical models were built to determine the parameters that influence the effectiveness of hydraulic fracturing. The average annual increase in oil production is used as a dependent variable; geological, technological and technical parameters are used as independent variables. To determine the degree of impact of parameters wells are divided into two classes of effectiveness: Qo > 8 tons/day (class 1), Qo < 8 tons/day (class 2). For the first class of each parameter individual statistical models are built for prediction and its probability is calculated. For the combined use of individual models complex probability is calculated separately for geological technological and technical indicators. As a result, regression models are built using step-by-step regression analysis. The standard error of the model for geological and technological parameters is 2.0 tons/day and 2.2 tons/day for technical. The joint consideration of geological technological and technical parameters in the regression model reduces the standard error to 1.5 tons/day. It is concluded that a separate description of the processes of hydraulic fracturing allows evaluating the efficiency of hydraulic fracturing in specific geological and technological conditions at the design stage, based on the use of developed individual models. After the hydraulic fracturing performed using the developed models considering technical conditions it is possible to preliminary estimate the effectiveness of hydraulic fracturing. The developed methodology for predicting the efficiency of hydraulic fracturing, performed on the Tl-Bb reservoir, is recommended to be used at other reservoirs of the field after correction of the built models. On the other fields where information for building the probabilistic and statistical models is available, it is necessary to develop new probabilistic and statistical models

Study of oil recovery from reservoirs of different void types with use of multidimensional statistical analysis

Oil recovery laws that take into account distribution of reservoirs with different void types within the same accumulation. Carbonate field data of development of Tournaisian-Famennian oil accumulation was used. For comparison purposes data of development of the field with similar oil properties but reservoir of clastic grain rock and pore type were used. One injector and neighbor producers were used as components of applied production scheme. The type of reservoir within one development object was determined by several studies including pressure build-up curve processed by Warren-Root method. At the first stage correlation coefficients between injection and production of neighbor well were calculated. Calculation was done for different time and with assumption, according to which correlation coefficient is a quantitative measure of interactions between two wells. It is determined that use of correlation coefficient for pore reservoirs is significantly differ to the character of its behavior for fracture reservoir type. Multidimensional mathematical models that characterize flooding and allow determining producer’s rate were obtained with considered void type. Linear discriminant functions are built with considered void type of reservoir. Analysis of those functions determined that replacement of oil by water in clastic and carbonates porous rocks and carbonate naturally fractured reservoirs follow different scenarios

Development of the methodology for evaluation of possibilities to determine reservoir types based on pressure build-up curves, geological and reservoir properties of the formation (case study of famen deposits of Ozernoe field)

One of the features of geological structure of Famen deposits of Ozernoe field is naturally fractured reservoir zones. Results of hydrodynamic study of wells on unsteady regime that were processed by Warren-Root model show that naturally fractured zones are oriented North-East. In order to prove existence of zones with different reservoirs statistical analysis was performed. Wherein geological and physical reservoir parameters (absolute elevation, thickness, permeability), several parameters of well performance (initial rate, productivity index) and litho-facial analysis (on cores and seismic) were additionally involved. In this paper interval probabilities that belong to naturally fractured and pore types are determined. Average values of varying intervals compared with interval probabilities. Based on that data pair correlation coefficients calculated and regression equations are built taking into account all studying parameters. Correlation between probability values and addition values are shown on graph. Graphs show probability of naturally fractured reservoir existence for different values of geological and technological parameters. To build the optimal forecast model using individual probability generalized probability were calculated. Scheme that reflect its change on the area of the deposit is built. Analysis show that wells belong to cavitation type determined base on pressure build-up curves in accordance with Warren-Root model is proved by obtained reservoir characteristics. The methodology for reservoir type determination has several advantages, can be implemented on the other fields that are similar in terms of geological structure and Oil and Gas province

ОСОБЛИВОСТІ БІОЦЕНОЗУ ПІХВИ У ЖІНОК ІЗ МІКОПЛАЗМОВОЮ ІНФЕКЦІЄЮ

The aim of the study – to assess the features of the genital biome and the structure of associative forms of vaginal infection in women with mycoplasma infection. Materials and Methods. 80 women with mycoplasma infection and inflammatory diseases of the genital tract (group I) and 70 women without mycoplasma infection, but with inflammatory diseases of the genital tract (group II) were examined. Microbiological analyzes were carried out and the results were recorded in accordance with order No. 234 of the Ministry of Health of Ukraine dated May 10, 2007. Gardnerellа was diagnosed by the method of bacterioscopy by staining smears according to Romanovsky, followed by taking into account the "key" cells, setting the amine test, and determining the pH. Chlamydia was diagnosed by the luminescent method using the "Chlamy-Scan" kits (Moscow, Russia). The diagnosis of mycoplasmosis was carried out by two methods: the luminescent method using ‘‘Miko-Scan’’ kits (Moscow, Russia) and the culture method using an electrolyte-deficient nutrient agar for the isolation and identification of microorganisms in the urine (Makhachkala, Russia). The results of bacteriological studies were subject to statistical processing using the Student's method. Results and Discussion. The biome of the vagina was studied in women with mycoplasma infection and inflammatory diseases of the genital tract. It was found that the microecology of the vagina in the examined women is characterized by an imbalance between the normal microflora of Lactobacillus and conditionally pathogenic microflora and the formation of 3–4 component associations of aerobic and anaerobic microorganisms, fungi of Candida in combination with Chlamidya trahomatis. It was found that in women with inflammatory diseases of the genital tract without mycoplasma infection, the vaginal biocenosis differs from the state of microecology of the genital organs of women with mycoplasma infection by a decrease in the frequency of diagnosis of chlamydia and gardnerellosis against the background of an increase in the concentration of opportunistic microflora. Conclusions. The results of the work indicate the need for bacteriological examination of women for the presence of mycoplasma infection, an in-depth study of the etiology of infectious and inflammatory diseases of the genital organs and the use of adequate methods for the prevention and treatment of vaginal dysbiotic diseases.Цель исследования – изучить особенность биома половых органов и структуру ассоциативных форм инфицирования влагалища у женщин с микоплазменной инфекцией. Материалы и методы. Обследовано 80 женщин с микоплазменной инфекцией и воспалительными заболеваниями половых путей (I группа) и 70 женщин без микоплазменной инфекции и с воспалительными заболеваниями половых путей (II группа). Проведение микробиологических анализов и учет результатов осуществляли согласно приказу № 234 МОЗ Украины от 10.05.2007 года. Гарднереллез диагностировали методом бактериоскопии путем окрашивания мазков по Романовскому с последующим учетом «ключевых» клеток, постановкой аминового теста, определением рН. Диагностику хламидиоза осуществляли люминесцентным методом с помощью наборов «Хлами-Скан» (Москва, Россия). Диагностику микоплазмоза осуществляли двумя методами: люминесцентным методом, с помощью наборов «Мико-Скан» (Москва, Россия) и культуральным методом с применением электролит-дефицитного питательного агара для выделения и идентификации микроорганизмов в моче (Махачкала, Россия). Результаты бактериологических исследований подлежали статистической обработке по методу Стьюдента. Результаты исследования и их обсуждение. Установлено, что микроэкология влагалища у обследованных женщин характеризуется дисбалансом между нормальной микрофлорой Lactobacillus и условно-патогенной микрофлорой и формированием 3–4-компонентных ассоциаций аэробных и анаэробных микроорганизмов, грибов р. Candida в сочетании с Chlamydia trahomatis. Установлено, что у пациенток с воспалительными заболеваниями половых путей без микоплазменной инфекции биоценоз влагалища отличается от состояния микроэкологии половых органов женщин с микоплазменной инфекцией снижением частоты диагностики хламидиоза и гарднереллеза на фоне увеличения концентрации условно-патогенной микрофлоры. Выводы. Результаты работы свидетельствуют о необходимости бактериологического обследования женщин на наличие микоплазменной инфекции, углубленного изучения этиологии инфекционно-воспалительных заболеваний половых органов и применения адекватных методов профилактики и терапии дисбиотических заболеваний влагалища.Мета дослідження – вивчити особливості біому статевих органів та структуру асоціативних форм інфікування піхви у жінок із мікоплазмовою інфекцією. Матеріали та методи. Обстежено 80 жінок із мікоплазмовою інфекцією та запальними захворюваннями статевих шляхів (І група) та 70 жінок без мікоплазмової інфекції, але із запальними захворюваннями статевих шляхів (ІІ група). Проведення мікробіологічних досліджень та облік результатів здійснювали відповідно до наказу № 234 МОЗ України від 10.05.2007 року. Гарднерельоз діагностували методом бактеріоскопії шляхом фарбування мазків за Романовським із подальшим урахуванням «ключових» клітин, постановкою амінового тесту та визначенням pН. Діагностику хламідіозу здійснювали люмінесцентним методом за допомогою наборів «Хламі-Скан» (Москва, Росія). Діагностику мікоплазмозу здійснювали двома методами: люмінесцентним методом, за допомогою наборів «Міко-Скан» (Москва, Росія) та культуральним методом із застосуванням електроліт-дефіцитного поживного агару для виділення та ідентифікації мікроорганізмів у сечі (Махачкала, Росія). Результати бактеріологічних досліджень підлягали статистичній обробці за методом Стьюдента. Результати дослідження та їх обговорення. Встановлено, що мікроекологія піхви в обстежених жінок характеризується дисбалансом між нормальною мікрофлорою Lactobacillus та умовно-патогенною мікрофлорою та формуванням 3–4-компонентних асоціацій аеробних та анаеробних мікроорганізмів, грибів р. Candida в поєднанні з Chlamydia trahomatis. Виявлено, що у пацієнток із запальними захворюваннями статевих шляхів без мікоплазмової інфекції біоценоз піхви відрізняється від стану мікроекології статевих органів жінок із мікоплазмовою інфекцією зниженням частоти діагностики хламідіозу та гарднерельозу на фоні збільшення концентрації умовно-патогенної мікрофлори. Висновки. Результати роботи свідчать про необхідність бактеріологічного обстеження жінок на наявність мікоплазмової інфекції, поглибленого вивчення етіології інфекційно-запальних захворювань статевих органів та застосування адекватних методів профілактики й терапії дисбіотичних захворювань піхви

The article considers the economic phenomenon of MMM as an organization And S. p. Mavrodi, whose personality, as well as his activities, still cause extremely ambiguous assessments.

The article considers the economic phenomenon of MMM as an organization And S. p. Mavrodi, whose personality, as well as his activities, still cause extremely ambiguous assessments.В статье рассмотрен экономический феномен МММ как организации и С. П. Мавроди, личность которого, как и его деятельность, до сих пор вызывают крайне неоднозначные оценки

New opportunities of increase of complex therapy productivity with the symptomatic locally-caused epilepsy with the resistant current

Efficiency of Phenotropili preparation was studied in jugulating of asthenia among patients with resistant symptomatic localization related epilepsy. Some patients (62 persons) against the basic antiepileptic therapies put on Phenotropili in a dose 100 mg (18 persons) and 200 mg (22 persons) a day in a continuous course, during 3 months. The assessment of this therapy influence was conducted in relation to the group accepting a placebo (22 persons). It was specified an authentic decrease of all types of asthenia, and efficiency of a preparation in a dose of 100 mg a day practically didn't concede efficiency of 200 mg a day.Изучалась эффективность препарата Фенотропил® при купировании астении у пациентов с резистентной симптоматической локально-обусловленной эпилепсией. Пациентам (62 человека) на фоне базисной антиэпилептической терапии назначался Фенотропил® в дозе 100 (18 человек) и 200 мг (22 человека) в сутки непрерывным курсом, длительностью 3 месяца. Оценка влияния этой терапии велась по отношению к группе, принимающей плацебо (22 человека). Отмечено достоверное снижение всех типов астении, причем эффективность препарата в дозе 100 мг в сутки практически не уступала эффективности 200 мг в сутки

Применение антагонистов лейкотриеновых рецепторов при лечении больных бронхиальной астмой

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Ferroptosis-associated lesion as a potential target for cardiovascular disease: A review

Cell death is an important feature of the development of multicellular organisms, a critical factor in the occurrence of cardiovascular diseases. Understanding the mechanisms that control cell death is crucial to determine its role in the development of the pathological process. However, the most well-known types of cell death cannot fully explain the pathophysiology of heart disease. Understanding how cardiomyocytes die and why their regeneration is limited is an important area of research. Ferroptosis is an iron-dependent cell death that differs from apoptosis, necrosis, autophagy, and other forms of cell death in terms of morphology, metabolism, and protein expression. Ferroptotic cell death is characterized by the accumulation of reactive oxygen species resulting from lipid peroxidation and subsequent oxidative stress, which can be prevented by iron chelates (eg, deferoxamine) and small lipophilic antioxidants (eg, ferrostatin, liproхstatin). In recent years, many studies have been carried out on ferroptosis in the context of the development of atherosclerosis, myocardial infarction, heart failure, and other diseases. In addition to cardiovascular diseases, the review also presents data on the role of ferroptosis in the development of other socially significant diseases, such as COVID-19, chronic obstructive pulmonary disease. With the study of ferroptosis, it turned out that ferroptosis participates in the development of bacterial infection associated with the persistence in the host body of Pseudomonas aeruginosa. The review summarizes the recent advances in the study of ferroptosis, characterizing this type of cell death as a novel therapeutic target