Experimental Measurement of Particle Dispersion in Turbulent Flow

The dispersion of particles in turbulent flows, phenomena such as dispersion, diffusion, and sedimentation, and a more fundamental point of view, the description of particle interaction with the turbulent field are recently of increasing interest. A system capable of investigating statistical structure of the motion of particles in a turbulent fluid flow using a turbulent water pipe flow system and particles tagged with C0-60 radioactive pellets has been constructed and tested. The particles were followed in their trajectory by a group of detectors consisting of NaI(Tℓ) crystals mounted on photomultiplier tubes which move with the particles on a movable carriage. From the photomultiplier voltages a time series of particle position and velocity was calculated. Results included Eulerian and convected frame measurements in the underlying fluid field in the pipe, representative measurements from recent experiments with particles, and an analysis of noise and statistical reliability of the results

SCOS 2: ESA's new generation of mission control system

New mission-control infrastructure is currently being developed by ESOC, which will constitute the second generation of the Spacecraft Control Operations system (SCOS 2). The financial, functional and strategic requirements lying behind the new development are explained. The SCOS 2 approach is described. The technological implications of these approaches is described: in particular it is explained how this leads to the use of object oriented techniques to provide the required 'building block' approach. The paper summarizes the way in which the financial, functional and strategic requirements have been met through this combination of solutions. Finally, the paper outlines the development process to date, noting how risk reduction was achieved in the approach to new technologies and summarizes the current status future plans

IMBES pre-conference: using insight from research to improve education

In September 2016, the International Mind, Brain, and Education Society (IMBES) biennial conference took place in Toronto, Canada. The pre-conference (organized by the Wellcome Trust) was designed to share new findings, lessons learned, and inspirational innovation within the field, and to encourage the community to not only identify current challenges, but to start planning potential ways to address them. This article provides a brief summary of the discussions from the day, and suggests steps that members of the community, conference organizers, and funders can take in helping to move the field forward. Finally, it outlines new work Wellcome has commissioned since the conference in response to some of the challenges defined on the day

Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize.

Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes. To overcome radioresistance, certain drugs have been found to sensitize cells to ionizing radiation (IR). In theory, more potent radiosensitizing drugs should increase tumour kill and improve patient outcomes. In practice, clinical utility of potent radiosensitizing drugs is curtailed by off-target side effects. Here we report potent anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize to tumours based on surface receptor expression. While two classes of potent anti-tubulins, auristatins and maytansinoids, indiscriminately radiosensitize tumour cells, conjugating these potent anti-tubulins to anti-ErbB antibodies restrict their radiosensitizing capacity. Of translational significance, we report that a clinically used maytansinoid ADC, ado-trastuzumab emtansine (T-DM1), with IR prolongs tumour control in target expressing HER2+ tumours but not target negative tumours. In contrast to ErbB signal inhibition, our findings establish an alternative therapeutic paradigm for ErbB-based radiosensitization using antibodies to restrict radiosensitizer delivery

A Review of Behavioral Conceptualizations and Treatments of Child Noncompliance

This article reviews behavioral conceptualizations and approaches to the treatment of child noncompliance. This includes discussion of behavioral definitions and methods of assessment, generalization of treatment effects, future research directions, and potential ethical concerns in treating childhood noncompliance

The Simultaneous Presentation Procedure: Use in Selecting Reinforcers for Behavioral Intervention

Used a simultaneous presentation procedure to select quality reinforcers for 2 identical twin boys (aged 4 yrs) in a summer school program, who were developmentally delayed, noncompliant, and mute. Use of the simultaneous presentation procedure quickly and efficiently helped determine each boy\u27s preferred reinforcer. This preferred reinforcer was then used in an instructional task. For both Ss, the percentage of compliance increased over baseline levels during both the simultaneous presentation and preferred reinforcer phases. However, increased compliance was associated almost exclusively with the selection of each S\u27s preferred reinforcer. The simultaneous presentation procedure may enable trainers to use positive reinforcement instead of negative reinforcement procedures for individuals with disabilities, thus increasing the efficacy and the acceptability of training

S_3 and the L=1 Baryons in the Quark Model and the Chiral Quark Model

The S_3 symmetry corresponding to permuting the positions of the quarks within a baryon allows us to study the 70-plet of L=1 baryons without an explicit choice for the spatial part of the quark wave functions: given a set of operators with definite transformation properties under the spin-flavor group SU(3) x SU(2) and under this S_3, the masses of the baryons can be expressed in terms of a small number of unknown parameters which are fit to the observed L=1 baryon mass spectrum. This approach is applied to study both the quark model and chiral constituent quark model. The latter theory leads to a set of mass perturbations which more satisfactorily fits the observed L=1 baryon mass spectrum (though we can say nothing, within our approach, about the physical reasonableness of the parameters in the fit). Predictions for the mixing angles and the unobserved baryon masses are given for both models as well as a discussion of specific baryons.Comment: 24 pages, requires picte