162 research outputs found
SocialLink: exploiting graph embeddings to link DBpedia entities to Twitter profiles
SocialLink is a project designed to match social media profiles on Twitter to corresponding entities in DBpedia. Built to bridge the vibrant Twitter social media world and the Linked Open Data cloud, SocialLink enables knowledge transfer between the two, both assisting Semantic Web practitioners in better harvesting the vast amounts of information available on Twitter and allowing leveraging of DBpedia data for social media analysis tasks. In this paper, we further extend the original SocialLink approach by exploiting graph-based features based on both DBpedia and Twitter, represented as graph embeddings learned from vast amounts of unlabeled data. The introduction of such new features required to redesign our deep neural network-based candidate selection algorithm and, as a result, we experimentally demonstrate a significant improvement of the performances of SocialLink
Large Process Models: Business Process Management in the Age of Generative AI
The continued success of Large Language Models (LLMs) and other generative
artificial intelligence approaches highlights the advantages that large
information corpora can have over rigidly defined symbolic models, but also
serves as a proof-point of the challenges that purely statistics-based
approaches have in terms of safety and trustworthiness. As a framework for
contextualizing the potential, as well as the limitations of LLMs and other
foundation model-based technologies, we propose the concept of a Large Process
Model (LPM) that combines the correlation power of LLMs with the analytical
precision and reliability of knowledge-based systems and automated reasoning
approaches. LPMs are envisioned to directly utilize the wealth of process
management experience that experts have accumulated, as well as process
performance data of organizations with diverse characteristics, e.g., regarding
size, region, or industry. In this vision, the proposed LPM would allow
organizations to receive context-specific (tailored) process and other business
models, analytical deep-dives, and improvement recommendations. As such, they
would allow to substantially decrease the time and effort required for business
transformation, while also allowing for deeper, more impactful, and more
actionable insights than previously possible. We argue that implementing an LPM
is feasible, but also highlight limitations and research challenges that need
to be solved to implement particular aspects of the LPM vision
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
2-Oxoglutarate (2OG)-dependent oxygenases have important roles in the regulation of gene expression via demethylation of N-methylated chromatin components1,2 and in the hydroxylation of transcription factors3 and splicing factor proteins4. Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA5,6,7 and ribosomal proteins8 have been shown to be important in translation relating to cellular growth, TH17-cell differentiation and translational accuracy9,10,11,12. The finding that ribosomal oxygenases (ROXs) occur in organisms ranging from prokaryotes to humans8 raises questions as to their structural and evolutionary relationships. In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively. The functional assignments of ROXs open therapeutic possibilities via either ROX inhibition or targeting of differentially modified ribosomes. Despite differences in the residue and protein selectivities of prokaryotic and eukaryotic ROXs, comparison of the crystal structures of E. coli YcfD and Rhodothermus marinus YcfD with those of human MINA53 and NO66 reveals highly conserved folds and novel dimerization modes defining a new structural subfamily of 2OG-dependent oxygenases. ROX structures with and without their substrates support their functional assignments as hydroxylases but not demethylases, and reveal how the subfamily has evolved to catalyse the hydroxylation of different residue side chains of ribosomal proteins. Comparison of ROX crystal structures with those of other JmjC-domain-containing hydroxylases, including the hypoxia-inducible factor asparaginyl hydroxylase FIH and histone NĪµ-methyl lysine demethylases, identifies branch points in 2OG-dependent oxygenase evolution and distinguishes between JmjC-containing hydroxylases and demethylases catalysing modifications of translational and transcriptional machinery. The structures reveal that new protein hydroxylation activities can evolve by changing the coordination position from which the iron-bound substrate-oxidizing species reacts. This coordination flexibility has probably contributed to the evolution of the wide range of reactions catalysed by oxygenases
Pionska apsorpcija u 4He
This paper presents a large solid angle measurement of the positive pion absorption cross-section on 4He and its decomposition into partial channels. A large fraction of the absorption cross-section at incident pion kinetic energies of TĻ+ =70, 118, 162, 239, and 330 MeV is due to multinucleon channels.Daju se ishodi mjerenja pod velikim prostornim kutom udarnog presjeka za apsorpciju pozitivnih piona u He4 i razdjela na pojedine kanale. Velik dio apsorpcijskog udarnog presjeka za energije upadnih piona od TĻ+ =70, 118, 162, 239 i 330 MeV je posljedica viÅ”enukleonskih kanala
Pionska apsorpcija u 4He
This paper presents a large solid angle measurement of the positive pion absorption cross-section on 4He and its decomposition into partial channels. A large fraction of the absorption cross-section at incident pion kinetic energies of TĻ+ =70, 118, 162, 239, and 330 MeV is due to multinucleon channels.Daju se ishodi mjerenja pod velikim prostornim kutom udarnog presjeka za apsorpciju pozitivnih piona u He4 i razdjela na pojedine kanale. Velik dio apsorpcijskog udarnog presjeka za energije upadnih piona od TĻ+ =70, 118, 162, 239 i 330 MeV je posljedica viÅ”enukleonskih kanala
ViŔenukleonska emisija nakon pionske apsorpcije u N, Ar i Xe
Positive pion absorption was studied in an almost 4Ļ geometry allowing simultaneous measurements of various charge and neutral multiplicities. Total absorption cross sections and its decomposition into the most important channels is determined. The results are presented for N, Ar and Xe nuclei at incident pion energies of 118,162 and 239 MeV. The role of multinucleon emission in the absorption process is emphasized.ProuÄava se pionska apsorpcija s blizu 4Ļ detekcijom koja dozvoljava istovremeno mjerenje raznih nabojskih i neutralnih viÅ”estrukosti. OdreÄuju se ukupni udarni presjeci i njihovo razlaganje u najvažnije kanale. Predstavljaju se rezultati za jezgre N, Ar i Xe na energijama 118,162 i 239 MeV. IstiÄe se uloga viÅ”enukleonske emisije u procesu apsorpcije
ViŔenukleonska emisija nakon pionske apsorpcije u N, Ar i Xe
Positive pion absorption was studied in an almost 4Ļ geometry allowing simultaneous measurements of various charge and neutral multiplicities. Total absorption cross sections and its decomposition into the most important channels is determined. The results are presented for N, Ar and Xe nuclei at incident pion energies of 118,162 and 239 MeV. The role of multinucleon emission in the absorption process is emphasized.ProuÄava se pionska apsorpcija s blizu 4Ļ detekcijom koja dozvoljava istovremeno mjerenje raznih nabojskih i neutralnih viÅ”estrukosti. OdreÄuju se ukupni udarni presjeci i njihovo razlaganje u najvažnije kanale. Predstavljaju se rezultati za jezgre N, Ar i Xe na energijama 118,162 i 239 MeV. IstiÄe se uloga viÅ”enukleonske emisije u procesu apsorpcije
The development of compassionate engagement and action scales for self and others
Background Studies of the value of compassion on physical and mental health and social relationships have proliferated in the last 25 years. Although, there are several conceptualisations and measures of compassion, this study develops three new measures of compassion competencies derived from an evolutionary, motivational approach. The scales assess 1. the compassion we experience for others, 2. the compassion we experience from others, and 3. self-compassion based on a standard definition of compassion as a āsensitivity to suffering in self and others with a commitment to try to alleviate and prevent itā. We explored these in relationship to other compassion scales, self-criticism, depression, anxiety, stress and well-being. Methods Participants from three different countries (UK, Portugal and USA) completed a range of scales including compassion for others, self-compassion, self-criticism, shame, depression, anxiety and stress with the newly developed āThe Compassionate Engagement and Actionsā scale. Results All three scales have good validity. Interestingly, we found that the three orientations of compassion are only moderately correlated to one another (rā<ā.5). We also found that some elements of self-compassion (e.g., being sensitive to, and moved by oneās suffering) have a complex relationship with other attributes of compassion (e.g., empathy), and with depression, anxiety and stress. A path-analysis showed that self-compassion is a significant mediator of the association between self-reassurance and well-being, while self-criticism has a direct effect on depressive symptoms, not mediated by self-compassion. Discussion Compassion evolved from caring motivation and in humans is associated with a range of different socially intelligent competencies. Understanding how these competencies can be inhibited and facilitated is an important research endeavour. These new scales were designed to assess these competencies. Conclusions This is the first study to measure the three orientations of compassion derived from an evolutionary model of caring motivation with specified competencies. Our three new measures of compassion further indicate important complex relationships between different potentiationās of compassion, well-being, and vulnerability to psychopathologies.N/
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