5,643 research outputs found

    Timing of progression from Chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modelling study

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    PMCID: PMC3505463The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2334/12/187. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

    Herzog & Rowan, ISAZ 2019 Meeting Presentation

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    The presentation covers differences in relative pet dog (dogs per 1,000 people) and cat populations in different states in the United States and in different countries around the world

    Non-local two-photon correlations using interferometers physically separated by 35 meters

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    An experimental demonstration of quantum correlations is presented. Energy and time entangled photons at wavelengths of 704 and 1310 nm are produced by parametric downconversion in KNbO3 and are sent through optical fibers into a bulk-optical (704 nm) and an all-fiber Michelson-interferometer (1310 nm), respectively. The two interferometers are located 35 meters aside from one another. Using Faraday-mirrors in the fiber-interferometer, all birefringence effects in the fibers are automatically compensated. We obtained two-photon fringe visibilities of up to 95 % from which one can project a violation of Bell's inequality by 8 standard deviations. The good performance and the auto-aligning feature of Faraday-mirror interferometers show their potential for a future test of Bell's inequalities in order to examine quantum-correlations over long distances.Comment: 9 pages including 3 postscript figures, to be published in Europhys. Let

    Critical dynamics in spontaneous resting-state oscillations are associated with the attention-related P300 ERP in a go/nogo task

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    Sustained attention is the ability to continually concentrate on task-relevant information, even in the presence of distraction. Understanding the neural mechanisms underlying this ability is critical for comprehending attentional processes as well as neuropsychiatric disorders characterized by attentional deficits, such as attention deficit hyperactivity disorder (ADHD). In this study, we aimed to investigate how trait-like critical oscillations during rest relate to the P300 evoked potential-a biomarker commonly used to assess attentional deficits. We measured long-range temporal correlations (LRTC) in resting-state EEG oscillations as index for criticality of the signal. In addition, the attentional performance of the subjects was assessed as reaction time variability (RTV) in a continuous performance task following an oddball paradigm. P300 amplitude and latencies were obtained from EEG recordings during this task. We found that, after controlling for individual variability in task performance, LRTC were positively associated with P300 amplitudes but not latencies. In line with previous findings, good performance in the sustained attention task was related to higher P300 amplitudes and earlier peak latencies. Unexpectedly, we observed a positive relationship between LRTC in ongoing oscillations during rest and RTV, indicating that greater criticality in brain oscillations during rest relates to worse task performance. In summary, our results show that resting-state neuronal activity, which operates near a critical state, relates to the generation of higher P300 amplitudes. Brain dynamics close to criticality potentially foster a computationally advantageous state which promotes the ability to generate higher event-related potential (ERP) amplitudes

    Post-transcriptional regulation by 3' UTRs can be masked by regulatory elements in 5' UTRs

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    In mRNA sequences, 3' UTRs are thought to contain most elements that specifically regulate localization, turnover, and translation. Although high-throughput experiments indicate that many RNA-binding proteins (RBPs) also bind 5' UTRs, much less is known about specific post-transcriptional control exerted by 5' UTRs. GLD-1 is a conserved RBP and a translational repressor with essential roles in Caenorhabditis elegans germ cell development. Previously, we showed that GLD-1 binds highly conserved sites in both 3' and 5' UTRs. Here, by targeted single-copy insertion of transgenes, we systematically tested in vivo functionality of 5' and 3' UTR binding sites individually and in combination. Our data show that sites in 5' UTRs mediate specific and strong translational repression, independent of exact position. Intriguingly, we found that the functionality of 3' UTR sites can be masked by 5' UTR sites and vice versa. We conclude that it is important to study both UTRs simultaneously

    Compositional Performance Modelling with the TIPPtool

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    Stochastic process algebras have been proposed as compositional specification formalisms for performance models. In this paper, we describe a tool which aims at realising all beneficial aspects of compositional performance modelling, the TIPPtool. It incorporates methods for compositional specification as well as solution, based on state-of-the-art techniques, and wrapped in a user-friendly graphical front end. Apart from highlighting the general benefits of the tool, we also discuss some lessons learned during development and application of the TIPPtool. A non-trivial model of a real life communication system serves as a case study to illustrate benefits and limitations

    Health Behaviors and Behavior Change during Pregnancy: Theory-Based Investigation of Predictors and Interrelations

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    (1) Background: Preventing pregnancy complications and maternal deaths and helping women stay healthy before, during, and after pregnancy by means of sexual health and behavior is imperative. Previous research demonstrated that a lack of social support and perceived discrimination have adverse effects on pregnancy outcomes. These determinants may impact health behavior as an important mediator of pregnancy outcomes. To better understand this relation, the Compensatory Carry-Over Action Model (CCAM) was applied. The research question was: how do predictors of health behavior, specifically intention, planning, self-efficacy, social support, and discrimination, interrelate with different health behaviors during pregnancy? (2) Methods: By means of qualitative interviews with ten pregnant women (20–39 years, mean = 28.6) from different cultural backgrounds, the predictors of health behaviors and experiences with pregnancy, including racial discrimination, were investigated. (3) Results: Not all women changed their unhealthy behaviors even though their higher-level goal was to ensure their baby’s and their own health. This appeared partially due to lack of social support, racial discrimination, and unexpected pregnancy side effects. The women who previously performed health behaviors revealed a healthier pattern with maintaining or even expanding their health behaviors, while those performing no health behavior in the past reported more obstacles with a healthy lifestyle. (4) Conclusions: Pregnant women appear to be having difficulties translating good intentions into behavior. The reasons include lack of support, fear, and insecurity, which impact self-efficacy and planning. Improvements in health behaviors were facilitated by specific circumstances, such as working from home. Policy and practice should take these aspects into account and help mobilize support and overcome discrimination by means of more rights and support for pregnant women while also empowering the individuals

    Social Attitudes and Animals

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    This chapter is an overview of the attitudes of Americans toward the treatment and moral status of nonhuman animals. We discuss problems of attitude assessment, the social psychology of attitudes toward animals, and the complex relationship between attitudes and behavior. We also review changes in attitudes toward animals over the past fifty years and current public opinion regarding a variety of issues related to animal welfare

    The large N limit of M2-branes on Lens spaces

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    We study the matrix model for N M2-branes wrapping a Lens space L(p,1) = S^3/Z_p. This arises from localization of the partition function of the ABJM theory, and has some novel features compared with the case of a three-sphere, including a sum over flat connections and a potential that depends non-trivially on p. We study the matrix model both numerically and analytically in the large N limit, finding that a certain family of p flat connections give an equal dominant contribution. At large N we find the same eigenvalue distribution for all p, and show that the free energy is simply 1/p times the free energy on a three-sphere, in agreement with gravity dual expectations.Comment: 28 pages, 4 figure
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