3D Numerical Modelling of Turbulent Flow in a Channel Partially Filled with Different Blockage Ratios of Metal Foam

The aim of the present research work is to understand the intricacies of fluid flow through a rectangular channel that has been partially filled with a metal foam block of different blockage ratio (0.16-1), with a pore density (5–30 Pores Per Inch i.e. PPI), along with varying inlet velocity (6.5–12.5 m/s). For the porous region, numerical solutions are acquired using the Darcy Extended Forchheimer model. The Navier-Stokes equation is used in the non-porous zone. Different flow behaviours were seen as a function of PPI, height, and inlet velocity. The pressure drop increases with inlet velocity, PPI, and block height, with a maximum value of approximately 4.5 kPa for the case of 30 PPI, 12.5 m/s, and a blockage ratio of 1. Results show that the existence and location of the formation of eddies depends on the inlet velocity, PPI, and blockage ratio. Such studies have been reported less and will aid research on forced convection through a channel partially filled with metal foam and optimisation studies between increased heat transmission and the additional pressure drop for the same by providing a detailed fluid flow analysis

Genetic variability among _Coleus sp_ studied by RAPD banding pattern analysis

Genetic improvement of the medicinal plants depends upon the existence, nature and extent of the genetic variability available for manipulation. Genetic analysis with RAPD markers has been extensively used to determine genetic diversity among _Coleus sp_ and to identify the best quality for human consumption for its medicinal purpose. The objectives of the present study were to assess molecular variation among _C.amboinicus_, _C.aromaticus_ and _C.forskohlii_. and to determine the level of genetic similarity among them. We performed random amplification of polymorphic DNA (RAPD) analysis on three strains of _Coleus sp_. Random primers were used for the PCR. Electrophoresis on denaturing acrylamide gels improved RAPD reproducibility and increased the band number. The primer OPW 6 and OPW 7 gave reproducible results and the band profiles

Solanum tuberosum L: Botanical, Phytochemical, Pharmacological and Nutritional Significance

Solanum tuberosum commonly known as potato belongs to solanaceae family. The whole part of potato plant including leaves; tuber, peel and juice are used in traditional medicine. A number of pharmacological activities of potato have been reported viz. Antioxidant, anticancer, antiallergy, antibacterial, anti-inflammatory, antiobesity, anti-ulcer activity. Potato contains Phenolic acids, anthocyanin, flavonoids, vitamin B6, vitamin B3, pantothenic acid, potassium, manganese, phosphorous; copper and fibres. The medicinal properties, traditional uses, nutritional value, phytochemical constituents, taxonomy, geographic origin and distribution have been mentioned in this present review to provide collective data for multipurpose benefits.

From Khoi-San indigenous knowledge to bioengineered CeO2 nanocrystals to exceptional UV-blocking green nanocosmetics

Single phase CeO2 nanocrystals were bio-synthesized using Hoodia gordonii natural extract as an effective chelating agent. The nanocrystals with an average diameter of 〈Ø〉 ~ 5–26 nm with 4+ electronic valence of Ce displayed a remarkable UV selectivity and an exceptional photostability. The diffuse reflectivity profile of such CeO2 exhibited a unique UV selectivity, in a form of a Heaviside function-like type profile in the solar spectrum. While the UV reflectivity is significantly low; within the range of 0.7%, it reaches 63% in the VIS and NIR. Their relative Reactive Oxygen Species (ROS) production was found to be < 1 within a wide range of concentration (0.5–1000 μg/ml). This exceptional photostability conjugated to a sound UV selectivity opens a potential horizon to a novel family of green nano-cosmetics by green nano-processing

MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium

Little is known about the molecular mechanism including microRNAs (miRNA) in hypercholesterolemia-induced cardiac dysfunction. We aimed to explore novel hypercholesterolemia-induced pathway alterations in the heart by an unbiased approach based on miRNA omics, target prediction and validation. With miRNA microarray we identified forty-seven upregulated and ten downregulated miRNAs in hypercholesterolemic rat hearts compared to the normocholesterolemic group. Eleven mRNAs with at least 4 interacting upregulated miRNAs were selected by a network theoretical approach, out of which 3 mRNAs (beta-2 adrenergic receptor [Adrb2], calcineurin B type 1 [Ppp3r1] and calcium/calmodulin-dependent serine protein kinase [Cask]) were validated with qRT-PCR and Western blot. In hypercholesterolemic hearts, the expression of Adrb2 mRNA was significantly decreased. ADRB2 and PPP3R1 protein were significantly downregulated in hypercholesterolemic hearts. The direct interaction of Adrb2 with upregulated miRNAs was demonstrated by luciferase reporter assay. Gene ontology analysis revealed that the majority of the predicted mRNA changes may contribute to the hypercholesterolemia-induced cardiac dysfunction. In summary, the present unbiased target prediction approach based on global cardiac miRNA expression profiling revealed for the first time in the literature that both the mRNA and protein product of Adrb2 and PPP3R1 protein are decreased in the hypercholesterolemic heart

Effects of molecular structure on the physical, chemical, and electrical properties of ester‐based transformer insulating liquids

This article presents the experimental studies carried out on the environmental friendly polyol ester insulating liquids to investigate the effect of molecular structure on the physical, chemical, and electrical properties. Six different polyol esters that can be produced from the transesterification of various methyl esters with neopentylglycol/trimethylolpropane alcohols were synthesized and compared with those of refined, bleached, and deodorized palm oil (RBDPO) and mineral transformer oil. The finding suggests that the physical properties like fire point, pour point, and viscosity are very much affected by the molecular weight and molecular composition of the polyol esters. The electrical properties are also highly influenced by the molecular structure‐related characteristics, such as the polarity, dipole polarization, carbon chain length, and degree of branching. The results confirm the findings of previous studies that the polyol esters and RBDPO have more polarity and dipole polarization compared to mineral oil. The experimental evidence showed that the newly synthesized insulating liquids have favorable thermal and electrical properties, thus suggesting that the insulating liquids have the potential to replace conventional insulating liquids to provide a more sustainable power system in the future

The first HyDRA challenge for computational vibrational spectroscopy

Vibrational spectroscopy in supersonic jet expansions is a powerful tool to assess molecular aggregates in close to ideal conditions for the benchmarking of quantum chemical approaches. The low temperatures achieved as well as the absence of environment effects allow for a direct comparison between computed and experimental spectra. This provides potential benchmarking data which can be revisited to hone different computational techniques, and it allows for the critical analysis of procedures under the setting of a blind challenge. In the latter case, the final result is unknown to modellers, providing an unbiased testing opportunity for quantum chemical models. In this work, we present the spectroscopic and computational results for the first HyDRA blind challenge. The latter deals with the prediction of water donor stretching vibrations in monohydrates of organic molecules. This edition features a test set of 10 systems. Experimental water donor OH vibrational wavenumbers for the vacuum-isolated monohydrates of formaldehyde, tetrahydrofuran, pyridine, tetrahydrothiophene, trifluoroethanol, methyl lactate, dimethylimidazolidinone, cyclooctanone, trifluoroacetophenone and 1-phenylcyclohexane-cis-1,2-diol are provided. The results of the challenge show promising predictive properties in both purely quantum mechanical approaches as well as regression and other machine learning strategies

Various Trade-Off Scenarios in Thermo-Hydrodynamic Performance of Metal Foams Due to Variations in Their Thickness and Structural Conditions

The long standing issue of increased heat transfer, always accompanied by increased pressure drop using metal foams, is addressed in the present work. Heat transfer and pressure drop, both of various magnitudes, can be observed in respect to various flow and heat transfer influencing aspects of considered metal foams. In this regard, for the first time, orderly varying pore density (characterized by visible pores per inch, i.e., PPI) and porosity (characterized by ratio of void volume to total volume) along with varied thickness are considered to comprehensively analyze variation in the trade-off scenario between flow resistance minimization and heat transfer augmentation behavior of metal foams with the help of numerical simulations and TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) which is a multi-criteria decision-making tool to address the considered multi-objective problem. A numerical domain of vertical channel is modelled with zone of metal foam porous media at the channel center by invoking LTNE and Darcy–Forchheimer models. Metal foams of four thickness ratios are considered (1, 0.75, 0.5 and 0.25), along with varied pore density (5, 10, 15, 20 and 25 PPI), each at various porosity conditions of 0.8, 0.85, 0.9 and 0.95 porosity. Numerically obtained pressure and temperature field data are critically analyzed for various trade-off scenarios exhibited under the abovementioned variable conditions. A type of metal foam based on its morphological (pore density and porosity) and configurational (thickness) aspects, which can participate in a desired trade-off scenario between flow resistance and heat transfer, is illustrated

Various Trade-Off Scenarios in Thermo-Hydrodynamic Performance of Metal Foams Due to Variations in Their Thickness and Structural Conditions

The long standing issue of increased heat transfer, always accompanied by increased pressure drop using metal foams, is addressed in the present work. Heat transfer and pressure drop, both of various magnitudes, can be observed in respect to various flow and heat transfer influencing aspects of considered metal foams. In this regard, for the first time, orderly varying pore density (characterized by visible pores per inch, i.e., PPI) and porosity (characterized by ratio of void volume to total volume) along with varied thickness are considered to comprehensively analyze variation in the trade-off scenario between flow resistance minimization and heat transfer augmentation behavior of metal foams with the help of numerical simulations and TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) which is a multi-criteria decision-making tool to address the considered multi-objective problem. A numerical domain of vertical channel is modelled with zone of metal foam porous media at the channel center by invoking LTNE and Darcy&ndash;Forchheimer models. Metal foams of four thickness ratios are considered (1, 0.75, 0.5 and 0.25), along with varied pore density (5, 10, 15, 20 and 25 PPI), each at various porosity conditions of 0.8, 0.85, 0.9 and 0.95 porosity. Numerically obtained pressure and temperature field data are critically analyzed for various trade-off scenarios exhibited under the abovementioned variable conditions. A type of metal foam based on its morphological (pore density and porosity) and configurational (thickness) aspects, which can participate in a desired trade-off scenario between flow resistance and heat transfer, is illustrated

Numerical Study for Enhancement of Heat Transfer Using Discrete Metal Foam with Varying Thickness and Porosity in Solar Air Heater by LTNE Method

A two-dimensional rectangular domain is considered with a discrete arrangement at equal distances from copper metal foam in a solar air heater (SAH). The local thermal non-equilibrium model is used for the analysis of heat transfer in a single-pass rectangular channel of SAH for different mass flow rates ranging from 0.03 to 0.05 kg/s at 850 W/m2 heat flux. Three different pores per inch (PPI) and porosities of copper metal foam with three different discrete thicknesses at equal distances are studied numerically. This paper evaluates the performance of SAH with 10 PPI 0.8769 porosity, 20 PPI 0.8567 porosity, and 30 PPI 0.92 porosity at 22 mm, 44 mm, and 88 mm thicknesses. The Nusselt number for 22 mm, 44 mm, and 88 mm thicknesses is 157.64%, 183.31%, and 218.60%, respectively, higher than the empty channel. The performance factor for 22 mm thick metal foam is 5.02% and 16.61% higher than for 44 mm and 88 mm thick metal foam, respectively. Hence, it is found that metal foam can be an excellent option for heat transfer enhancement in SAH, if it is designed properly