Consistent Estimation of Mixed Memberships with Successive Projections

This paper considers the parameter estimation problem in Mixed Membership Stochastic Block Model (MMSB), which is a quite general instance of random graph model allowing for overlapping community structure. We present the new algorithm successive projection overlapping clustering (SPOC) which combines the ideas of spectral clustering and geometric approach for separable non-negative matrix factorization. The proposed algorithm is provably consistent under MMSB with general conditions on the parameters of the model. SPOC is also shown to perform well experimentally in comparison to other algorithms

Oxygen sorbent

The present invention discloses a novel and unique family of agents which reversibly binds molecular oxygen at room temperature

Studies on the mode of action of reserpine

1. The actions of reserpine have been investigated using a number of tissues containing contractile elements. 2. Both the direct effects of reserpine and its actions upon drug- induced responses have been investigated. 3. Reserpine has been found to antagonise some of the effects of acetylcholine, (-)-adrenaline, (-)-noradrenaline, 5-hydroxytryptamine, pitressin, barium chloride and potassium chloride on such preparations as the frog rectus abdominis muscle, the isolated guinea-pig ileum, and auricles, the isolated perfused heart and the spinal cat. 4. It is suggested that reserpine may affect the metabolic processes which underlie muscular contraction

A novel role for the CBF3 kinetochore–scaffold complex in regulating septin dynamics and cytokinesis

In budding yeast, the kinetochore scaffold complex centromere binding factor 3 (CBF3) is required to form kinetochores on centromere DNA and to allow proper chromosome segregation. We have previously shown that SKP1 and SGT1 balance the assembly and turnover of CBF3 complexes, a cycle that we suggest is independent of its role in chromosome segregation (Rodrigo-Brenni, M.C., S. Thomas, D.C. Bouck, and K.B. Kaplan. 2004. Mol. Biol. Cell. 15:3366–3378). We provide evidence that this cycle contributes to a second, kinetochore-independent function of CBF3. In this study, we show that inhibiting the assembly of CBF3 causes disorganized septins and defects in cell polarity that give rise to cytokinesis failures. Specifically, we show that septin ring separation and disassembly is delayed in anaphase, suggesting that CBF3 regulates septin dynamics. Only mutations that affect the CBF3 cycle, and not mutants in outer kinetochore subunits, cause defects in septins. These results demonstrate a novel role for CBF3 in regulating cytokinesis, a role that is reminiscent of passenger proteins. Consistent with this possibility, we find that CBF3 interacts with Bir1p, the homologue of the passenger protein Survivin. Mutants in Bir1p similarly affect septin organization, leading us to propose that CBF3 and Bir1p act as passenger proteins to coordinate chromosome segregation with cytokinesis

Finding the coast: environmental governance and the characterisation of land and sea

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.In environmental governance for land and sea, the cultural is increasingly imbricated with the natural in the language of ecosystem services and the promise of integrated management. We are witnessing accelerated efforts to bring cultural and natural landscape character assessments into dialogue with other sorts of planning and governance mechanisms for coastal and marine environments. As land, sea, nature and culture are brought into closer correspondence, the coast assumes ever greater significance as a site and object of decision‐making in planning and environmental governance. In this paper, I draw on the critical analytical techniques of cultural geography to argue that coasts suffer from definitional ambiguity and conceptual insufficiency, both of which are exemplified by landscape and seascape characterisation, with specific consequences for environmental governance. I argue that we need to (1) both recognise and destabilise the unhelpful dichotomy between land and sea embodied in landscape and seascape character assessments, which have their provenance in landscape architecture; and (2) engage new language and conceptual tools that help us to rethink coasts critically. To this end, later on this paper, I briefly discuss alternative ways of conceptualising the coast, for example as a liminal space

Rotation-induced 3D vorticity in 4He superfluid films adsorbed on a porous glass

Detailed study of torsional oscillator experiments under steady rotation up to 6.28 rad/sec is reported for a 4He superfluid monolayer film formed in 1 micrometer-pore diameter porous glass. We found a new dissipation peak with the height being in proportion to the rotation speed, which is located to the lower temperature than the vortex pair unbinding peak observed in the static state. We propose that 3D coreless vortices ("pore vortices") appear under rotation to explain this new peak. That is, the new peak originates from dissipation close to the pore vortex lines, where large superfluid velocity shifts the vortex pair unbinding dissipation to lower temperature. This explanation is confirmed by observation of nonlinear effects at high oscillation amplitudes.Comment: 4pages, 5figure

Clinical Implementation of Germ Line Cancer Pharmacogenetic Variants During the Next-Generation Sequencing Era

Over 100 FDA-approved medications include pharmacogenetic biomarkers in the drug label, many with cancer indications referencing germline DNA variations. With the advent of next-generation sequencing (NGS) and its rapidly increasing uptake into cancer research and clinical practice, an enormous amount of data to inform documented gene-drug associations will be collected, which must be exploited to optimize patient benefit. This state-of-the-art article focuses on the implementation of germline cancer pharmacogenetics into clinical practice. Specifically, it discusses the importance of germline variation in cancer and the role of NGS in pharmacogenetic discovery and implementation. In the context of a scenario where massive NGS-based genetic information will be increasingly available to health stakeholders, this review explores the ongoing debate over the threshold of evidence necessary for implementation, provides an overview of recommendations in cancer by professional organizations and regulatory bodies, discusses limitations of current guidelines and strategies to improve third-party coverage

Characterizing correlations of flow oscillations at bottlenecks

"Oscillations" occur in quite different kinds of many-particle-systems when two groups of particles with different directions of motion meet or intersect at a certain spot. We present a model of pedestrian motion that is able to reproduce oscillations with different characteristics. The Wald-Wolfowitz test and Gillis' correlated random walk are shown to hold observables that can be used to characterize different kinds of oscillations