8 research outputs found
Comparative evaluation of the antimicrobial activity of Citrullus colocynthis immature fruit and seed organic extracts
Gastrointestinal problems, dermatological, gynaecological and pulmonary infections produced by micro-organisms are widespread in the entire globe. The treatment of these infections is mainly based on the use of synthetic drugs which have lost, in recent years, their effectiveness, due to the development of resistant strains and the rise of opportunistic fungal infections. Tunisian traditional medicine is a potential source of new remedies namely, Citrullus colocynthis Schrad. (Cucurbitaceae). Lyophilized aqueous and organic extracts from immature fruits and seeds were screened for activity against gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Vibrio parahaemolyticus and Vibrio alginolyticus) and gram-positive (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes and Micrococcus luteus) bacteria and various Candida spp. (Candida glabrata, Candida albicans, Candida parapsilosis and Candida kreusei). Minimal inhibition concentrations (MICs) and minimal bactericidal/fungicidal concentrations (MBCs/MFCs) were used to investigate the antimicrobial activity. Extracts from the two C. colocynthis Schrad. organs, at immature state, inhibited the growth of all the tested strains. The highest antibacterial effects were obtained against E. coli (MIC = 0.006 mg/ml) with the fruit methanol and the seed petroleum extracts. Regarding the anticandidal activity assessment, seed extracts showed the lowest results. This study demonstrated the broad spectrum antimicrobial activity of C. colocynthis immature fruit and seed extracts.Key words: Citrullus colocynthis Schrad, fruits, seeds, organic extracts, antibacterial, anticandidal
Az Össz-szövetségi Tudományos és Műszaki Információs Intézet információs kiadványainak rendszere
This report gives an account on the development and activities of the scientific information branch of VINITI. As one of its results, the VTNITI's system of publications has been developed during the past 25 years. This system is based on the serials Referativnyj Zurnal (RÍ), Ekspress Informacija (El), Signal'naja Informacija (SI) and the series ltogi Nauki i Tehniki (INT). The report gives a detailed description of the role these publications play in the system of information supply. It discusses the problems associated with the development of an international information system on pubhshed documents (MISOD) organized within the International Scientific and Technical Information System of the socialist countries.A tanulmány ismerteti a VINITI tudományos információs iskolájának létrejöttét és munkásságát. Ennek egyik eredménye a VINITI információs kiadványainak rendszere, amely az elmúlt negyed század alatt alakult ki. A rendszer gerincét a Referativnüj Zsurnal (RZS), az Ekszpreszsz Informacija (El), a Szignal'naja Informacija (SZI) és az ltogi nauki i tehniki (INT) című kiadványok, ill. ezek sorozatai képezik. A tanulmány részletesen foglalkozik a VINITI információs kiadványainak szerepével az információellátás rendszerében és tárgyalja a szocialista államok Nemzetközi Tudományos-Műszaki Információs Rendszerének keretében szervezett publikált dokumentumokról tájékoztató nemzetközi információs rendszer (MISZOD) létrehozásával kapcsolatos kérdéseket
Anti-inflammatory evaluation of immature fruit and seed aqueous extracts from several populations of Tunisian Citrullus colocynthis Schrad
Plant extracts are some of the most attractive sources of new drugs and have shown promising results for the treatment of inflammation and immune-related diseases, including rheumatoid arthritis. Citrullus colocynthis Schrad. (Cucurbitaceae) endemic in Tunisia, is widely used in folk medicine to treat many inflammation disorders. The aim of this study is to quantify the alkaloid and the flavonoid levels of different populations of C. colocynthis fruit and seed aqueous extracts at immature state. After acute toxicity assay, these extracts were screened for anti-inflammatory activity using the carrageenaninduced paw edema assay in rats. Alkaloid and flavonoid levels vary among the population. The best anti-inflammatory activities were obtained with immature fruits from south Tunisia. Therefore, C. colocynthis Schrad. could be a potential useful product suitable for further evaluation for inflammatory diseases.Key words: Citrullus colocynthis Schrad., alkaloids, flavonoids, toxicity, anti-inflammatory, Tunisia
Influence of drug concentration on the diffusion parameters of caffeine
Background and Objectives : In the fields of the pharmaceutical and
cosmetic industries and in toxicology, the study of the skin
penetration of molecules is very interesting. Various studies have
considered the impact of different physicochemical drug
characteristics, skin thickness, and formulations, on the transition
from the surface of the skin to the underlying tissues or to the
systemic circulation; however, the influence of drug concentration on
the permeation flux of molecules has rarely been raised. Our study aims
to discover the influence of caffeine concentration in a formulation on
the percutaneous penetration from gels, as a result of different dose
applications to polysulfate membrane and human skin. Materials and
Methods : For this purpose, three identical base gels were used at 1,
3, and 5% of caffeine, to evaluate the effect of the concentration of
caffeine on in vitro release through the synthetic membrane and ex vivo
permeation through the human skin, using diffusion Franz TM cells.
Results : The diffusion through the epidermal tissue was significantly
slower than through the synthetic membrane, which recorded an increase
of flux with an increase in the concentration of caffeine. The skin
permeation study showed that diffusion depended not only on the
concentration, but also on the deposited amount of gel. Nevertheless,
for the same amount of caffeine applied, the flux was more significant
from the less concentrated gel. Conclusion : Among all the different
concentrations of caffeine examined, 1% gel of caffeine applied at 5 mg
/ cm 2 showed the highest absorption characteristics across human skin