625 research outputs found
Integral and Nonnegativity Preserving Approximations of Functions
In this paper we consider the problem of approximating a function by continuous piecewise linear functions that preserve the integral and nonnegativity of the original function. (c) 2006 Elsevier Inc. All rights reserved
Cosmic shear analysis of archival HST/ACS data: I. Comparison of early ACS pure parallel data to the HST/GEMS Survey
This is the first paper of a series describing our measurement of weak
lensing by large-scale structure using archival observations from the Advanced
Camera for Surveys (ACS) on board the Hubble Space Telescope (HST).
In this work we present results from a pilot study testing the capabilities
of the ACS for cosmic shear measurements with early parallel observations and
presenting a re-analysis of HST/ACS data from the GEMS survey and the GOODS
observations of the Chandra Deep Field South (CDFS). We describe our new
correction scheme for the time-dependent ACS PSF based on observations of
stellar fields. This is currently the only technique which takes the full time
variation of the PSF between individual ACS exposures into account. We estimate
that our PSF correction scheme reduces the systematic contribution to the shear
correlation functions due to PSF distortions to < 2*10^{-6} for galaxy fields
containing at least 10 stars. We perform a number of diagnostic tests
indicating that the remaining level of systematics is consistent with zero for
the GEMS and GOODS data confirming the success of our PSF correction scheme.
For the parallel data we detect a low level of remaining systematics which we
interpret to be caused by a lack of sufficient dithering of the data.
Combining the shear estimate of the GEMS and GOODS observations using 96
galaxies arcmin^{-2} with the photometric redshift catalogue of the GOODS-MUSIC
sample, we determine a local single field estimate for the mass power spectrum
normalisation sigma_{8,CDFS}=0.52^{+0.11}_{-0.15} (stat) +/- 0.07 (sys) (68%
confidence assuming Gaussian cosmic variance) at fixed Omega_m=0.3 for a
LambdaCDM cosmology. We interpret this exceptionally low estimate to be due to
a local under-density of the foreground structures in the CDFS.Comment: Version accepted for publication in Astronomy & Astrophysics with 28
pages, 25 figures. A version with full resolution figures can be downloaded
from http://www.astro.uni-bonn.de/~schrabba/papers/cosmic_shear_acs1_v2.pd
Looking through the same lens: Shear calibration for LSST, Euclid, and WFIRST with stage 4 CMB lensing
The next-generation weak lensing surveys (i.e., LSST, Euclid, and WFIRST) will require exquisite control over systematic effects. In this paper, we address shear calibration and present the most realistic forecast to date for LSST/Euclid/WFIRST and CMB lensing from a stage 4 CMB experiment (âCMB S4â). We use the cosmolike code to simulate a joint analysis of all the two-point functions of galaxy density, galaxy shear, and CMB lensing convergence. We include the full Gaussian and non-Gaussian covariances and explore the resulting joint likelihood with Monte Carlo Markov chains. We constrain shear calibration biases while simultaneously varying cosmological parameters, galaxy biases, and photometric redshift uncertainties. We find that CMB lensing from CMB S4 enables the calibration of the shear biases down to 0.2%â3% in ten tomographic bins for LSST (below the
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0.5
%
requirements in most tomographic bins), down to 0.4%â2.4% in ten bins for Euclid, and 0.6%â3.2% in ten bins for WFIRST. For a given lensing survey, the method works best at high redshift where shear calibration is otherwise most challenging. This self-calibration is robust to Gaussian photometric redshift uncertainties and to a reasonable level of intrinsic alignment. It is also robust to changes in the beam and the effectiveness of the component separation of the CMB experiment, and slowly dependent on its depth, making it possible with third-generation CMB experiments such as AdvACT and SPT-3G, as well as the Simons Observatory
Looking through the same lens: Shear calibration for LSST, Euclid, and WFIRST with stage 4 CMB lensing
Generalized compactness in linear spaces and its applications
The class of subsets of locally convex spaces called -compact sets is
considered. This class contains all compact sets as well as several noncompact
sets widely used in applications. It is shown that many results well known for
compact sets can be generalized to -compact sets. Several examples are
considered.
The main result of the paper is a generalization to -compact convex sets
of the Vesterstrom-O'Brien theorem showing equivalence of the particular
properties of a compact convex set (s.t. openness of the mixture map, openness
of the barycenter map and of its restriction to maximal measures, continuity of
a convex hull of any continuous function, continuity of a convex hull of any
concave continuous function). It is shown that the Vesterstrom-O'Brien theorem
does not hold for pointwise -compact convex sets defined by the slight
relaxing of the -compactness condition. Applications of the obtained
results to quantum information theory are considered.Comment: 27 pages, the minor corrections have been mad
Evidence for Color Dichotomy in the Primordial Neptunian Trojan Population
In the current model of early Solar System evolution, the stable members of
the Jovian and Neptunian Trojan populations were captured into resonance from
the leftover reservoir of planetesimals during the outward migration of the
giant planets. As a result, both Jovian and Neptunian Trojans share a common
origin with the primordial disk population, whose other surviving members
constitute today's trans-Neptunian object (TNO) populations. The cold classical
TNOs are ultra-red, while the dynamically excited "hot" population of TNOs
contains a mixture of ultra-red and blue objects. In contrast, Jovian and
Neptunian Trojans are observed to be blue. While the absence of ultra-red
Jovian Trojans can be readily explained by the sublimation of volatile material
from their surfaces due to the high flux of solar radiation at 5AU, the lack of
ultra-red Neptunian Trojans presents both a puzzle and a challenge to formation
models. In this work we report the discovery by the Dark Energy Survey (DES) of
two new dynamically stable L4 Neptunian Trojans,2013 VX30 and 2014 UU240, both
with inclinations i >30 degrees, making them the highest-inclination known
stable Neptunian Trojans. We have measured the colors of these and three other
dynamically stable Neptunian Trojans previously observed by DES, and find that
2013 VX30 is ultra-red, the first such Neptunian Trojan in its class. As such,
2013 VX30 may be a "missing link" between the Trojan and TNO populations. Using
a simulation of the DES TNO detection efficiency, we find that there are 162
+/- 73 Trojans with Hr < 10 at the L4 Lagrange point of Neptune. Moreover, the
blue-to-red Neptunian Trojan population ratio should be higher than 17:1. Based
on this result, we discuss the possible origin of the ultra-red Neptunian
Trojan population and its implications for the formation history of Neptunian
Trojans
Astrometric calibration and performance of the Dark Energy Camera
We characterize the ability of the Dark Energy Camera (DECam) to perform
relative astrometry across its 500~Mpix, 3 deg^2 science field of view, and
across 4 years of operation. This is done using internal comparisons of ~4x10^7
measurements of high-S/N stellar images obtained in repeat visits to fields of
moderate stellar density, with the telescope dithered to move the sources
around the array. An empirical astrometric model includes terms for: optical
distortions; stray electric fields in the CCD detectors; chromatic terms in the
instrumental and atmospheric optics; shifts in CCD relative positions of up to
~10 um when the DECam temperature cycles; and low-order distortions to each
exposure from changes in atmospheric refraction and telescope alignment. Errors
in this astrometric model are dominated by stochastic variations with typical
amplitudes of 10-30 mas (in a 30 s exposure) and 5-10 arcmin coherence length,
plausibly attributed to Kolmogorov-spectrum atmospheric turbulence. The size of
these atmospheric distortions is not closely related to the seeing. Given an
astrometric reference catalog at density ~0.7 arcmin^{-2}, e.g. from Gaia, the
typical atmospheric distortions can be interpolated to 7 mas RMS accuracy (for
30 s exposures) with 1 arcmin coherence length for residual errors. Remaining
detectable error contributors are 2-4 mas RMS from unmodelled stray electric
fields in the devices, and another 2-4 mas RMS from focal plane shifts between
camera thermal cycles. Thus the astrometric solution for a single DECam
exposure is accurate to 3-6 mas (0.02 pixels, or 300 nm) on the focal plane,
plus the stochastic atmospheric distortion.Comment: Submitted to PAS
Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs\u27 therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less frequently. The majority of irAEs are mild to moderate in severity; however, serious and occasionally life-threatening irAEs are reported in the literature, and treatment-related deaths occur in up to 2% of patients, varying by ICI. Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. There is an urgent need for multidisciplinary guidance reflecting broad-based perspectives on how to recognize, report and manage organ-specific toxicities until evidence-based data are available to inform clinical decision-making. The Society for Immunotherapy of Cancer (SITC) established a multidisciplinary Toxicity Management Working Group, which met for a full-day workshop to develop recommendations to standardize management of irAEs. Here we present their consensus recommendations on managing toxicities associated with immune checkpoint inhibitor therapy
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