174 research outputs found
Epidemiological study of canine trypanosomosis in an urban area of Ivory Coast
Following confirmed cases of trypanosomosis in military working dogs, c cross-sectional study was undertaken to evaluate the source of infection and determine the prevalence of canine infection with Trypanosoma congolense in the urban focus of Abidjan, Ivory Coast. Blood from 123 dogs were collected and subjected to PCR using specific primers for Trypanosoma congolense "forest type". In addition, an entomological study was conducted in an urban area near the forest surronding the military camp. The observed prevalence was 30.1% end PCR positivity to Trypanosoma congolense was not significantly associated with sex or age of animals. This study demonstrates the high contamination rate of dogs in enzootic zones, the potential risk of introduction of the disease in free animal populations and the ability of Glossina palpalis to adopt to urban areas and to transmit trypanosomosis in such areas. The factors leading to a possible emergence of canine trypanosomiasis in enzootic zones need further investigations
Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin
The coordinated migration and maturation of dendritic cells (DCs) such as intraepithelial Langerhans cells (LCs) is considered critical for T cell priming in response to inflammation in the periphery. However, little is known about the role of inflammatory mediators for LC maturation and recruitment to lymph nodes in vivo. Here we show in human dermatopathic lymphadenitis (DL), which features an expanded population of LCs in one draining lymph node associated with inflammatory lesions in its tributary skin area, that the Langerin/CD207+ LCs constitute a predominant population of immature DCs, which express CD1a, and CD68, but not CD83, CD86, and DC–lysosomal-associated membrane protein (LAMP)/CD208. Using LC-type cells generated in vitro in the presence of transforming growth factor (TGF)-β1, we further found that tumor necrosis factor (TNF)-α, as a prototype proinflammatory factor, and a variety of inflammatory stimuli and bacterial products, increase Langerin expression and Langerin dependent Birbeck granules formation in cell which nevertheless lack costimulatory molecules, DC–LAMP/CD208 and potent T cell stimulatory activity but express CCR7 and respond to the lymph node homing chemokines CCL19 and CCL21. This indicates that LC migration and maturation can be independently regulated events. We suggest that during DL, inflammatory stimuli in the skin increase the migration of LCs to the lymph node but without associated maturation. Immature LCs might regulate immune responses during chronic inflammation
Effect of a dc electric field on the liquid-vapor interface in a grooved flat heat pipe
In this communication, a grooved flat plate heat pipe is considered
with an electric field applied between the top and bottom
plates of the heat pipe. In this way, a dielectric force arises,
which aims at pumping the liquid phase together with the capillary
force. The ability of the electric field to change the shape
of the liquid-vapor interface is theoretically investigated by a numerical
approach. This approach consists in the strong coupling
between the Laplace-Young equation, extended with the electric
stress, and the Poisson equation for the electric potential. The
former is used for the calculation of the shape of the liquid-vapor
interface while the latter is solved for the determination of the
electric stress along the interface. The results show that the electric
field can extend the capillary limit of the heat pipe by increasing
the maximum curvature of the liquid-vapor interface before
the meniscus recession. This effect is even greater than the electric
pumping effect for non-wetting fluids. A final discussion is
presented to highlight the configurations for which the use of an
electric field yields significant improvements to the performance
of a grooved flat plate heat pipe.Papers presented at the 13th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Portoroz, Slovenia on 17-19 July 2017 .International centre for heat and mass transfer.American society of thermal and fluids engineers
The Mass Function of an X-Ray Flux-Limited Sample of Galaxy Clusters
A new X-ray selected and X-ray flux-limited galaxy cluster sample is
presented. Based on the ROSAT All-Sky Survey the 63 brightest clusters with
galactic latitude |bII| >= 20 deg and flux fx(0.1-2.4 keV) >= 2 * 10^{-11}
ergs/s/cm^2 have been compiled. Gravitational masses have been determined
utilizing intracluster gas density profiles, derived mainly from ROSAT PSPC
pointed observations, and gas temperatures, as published mainly from ASCA
observations, assuming hydrostatic equilibrium. This sample and an extended
sample of 106 galaxy clusters is used to establish the X-ray
luminosity--gravitational mass relation. From the complete sample the galaxy
cluster mass function is determined and used to constrain the mean cosmic
matter density and the amplitude of mass fluctuations. Comparison to
Press--Schechter type model mass functions in the framework of Cold Dark Matter
cosmological models and a Harrison--Zeldovich initial density fluctuation
spectrum yields the constraints OmegaM = 0.12^{+0.06}_{-0.04} and sigma8 =
0.96^{+0.15}_{-0.12} (90% c.l.). Various possible systematic uncertainties are
quantified. Adding all identified systematic uncertainties to the statistical
uncertainty in a worst case fashion results in an upper limit OmegaM < 0.31.
For comparison to previous results a relation sigma8 = 0.43 OmegaM^{-0.38} is
derived. The mass function is integrated to show that the contribution of mass
bound within virialized cluster regions to the total matter density is small,
i.e., OmegaCluster = 0.012^{+0.003}_{-0.004} for cluster masses larger than
6.4^{+0.7}_{-0.6} * 10^{13} h_{50}^{-1} Msun.Comment: 35 pages; accepted for publication in The Astrophysical Journal; this
and related papers, supplementary information, as well as electronic files of
the tables given in this paper are available at
http://www.astro.virginia.edu/~thr4f
The Northern ROSAT All-Sky (NORAS) Galaxy Cluster Survey I: X-ray Properties of Clusters Detected as Extended X-ray Sources
In the construction of an X-ray selected sample of galaxy clusters for
cosmological studies, we have assembled a sample of 495 X-ray sources found to
show extended X-ray emission in the first processing of the ROSAT All-Sky
Survey. The sample covers the celestial region with declination and galactic latitude and comprises sources with
a count rate counts s and a source extent likelihood of 7. In
an optical follow-up identification program we find 378 (76%) of these sources
to be clusters of galaxies. ...Comment: 61 pages; ApJS in press; fixed bug in table file; also available at
(better image quality) http://www.xray.mpe.mpg.de/theorie/NORAS
Controlling the dimensionality of low-Rm MHD turbulence experimentally
International audienc
Hepatitis C virus infection protein network
A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein–protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFβ pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins
The Updated Zwicky Catalog (UZC)
The Zwicky Catalog of galaxies (ZC), with m_Zw<=15.5mag, has been the basis
for the Center for Astrophysics (CfA) redshift surveys. To date, analyses of
the ZC and redshift surveys based on it have relied on heterogeneous sets of
galaxy coordinates and redshifts. Here we correct some of the inadequacies of
previous catalogs by providing: (1) coordinates with <~2 arcsec errors for all
of the Nuzc catalog galaxies, (2) homogeneously estimated redshifts for the
majority (98%) of the data taken at the CfA (14,632 spectra), and (3) an
estimate of the remaining "blunder" rate for both the CfA redshifts and for
those compiled from the literature. For the reanalyzed CfA data we include a
calibrated, uniformly determined error and an indication of the presence of
emission lines in each spectrum. We provide redshifts for 7,257 galaxies in the
CfA2 redshift survey not previously published; for another 5,625 CfA redshifts
we list the remeasured or uniformly re-reduced value. Among our new
measurements, Nmul are members of UZC "multiplets" associated with the original
Zwicky catalog position in the coordinate range where the catalog is 98%
complete. These multiplets provide new candidates for examination of tidal
interactions among galaxies. All of the new redshifts correspond to UZC
galaxies with properties recorded in the CfA redshift compilation known as
ZCAT. About 1,000 of our new measurements were motivated either by inadequate
signal-to-noise in the original spectrum or by an ambiguous identification of
the galaxy associated with a ZCAT redshift. The redshift catalog we include
here is ~96% complete to m_Zw<=15.5, and ~98% complete (12,925 galaxies out of
a total of 13,150) for the RA(1950) ranges [20h--4h] and [8h--17h] and
DEC(1950) range [-2.5d--50d]. (abridged)Comment: 34 pp, 7 figs, PASP 1999, 111, 43
Differentiation of mouse bone marrow derived stem cells toward microglia-like cells
<p>Abstract</p> <p>Background</p> <p>Microglia, the macrophages of the brain, have been implicated in the causes of neurodegenerative diseases and display a loss of function during aging. Throughout life, microglia are replenished by limited proliferation of resident microglial cells. Replenishment by bone marrow-derived progenitor cells is still under debate. In this context, we investigated the differentiation of mouse microglia from bone marrow (BM) stem cells. Furthermore, we looked at the effects of FMS-like tyrosine kinase 3 ligand (Flt3L), astrocyte-conditioned medium (ACM) and GM-CSF on the differentiation to microglia-like cells.</p> <p>Methods</p> <p>We assessed <it>in vitro-</it>derived microglia differentiation by marker expression (CD11b/CD45, F4/80), but also for the first time for functional performance (phagocytosis, oxidative burst) and <it>in situ </it>migration into living brain tissue. Integration, survival and migration were assessed in organotypic brain slices.</p> <p>Results</p> <p>The cells differentiated from mouse BM show function, markers and morphology of primary microglia and migrate into living brain tissue. Flt3L displays a negative effect on differentiation while GM-CSF enhances differentiation.</p> <p>Conclusion</p> <p>We conclude that <it>in vitro-</it>derived microglia are the phenotypic and functional equivalents to primary microglia and could be used in cell therapy.</p
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