Transition Metal Complexes of 6-Methyl-2-Amino Benzothiazole -Part III

Complexes of the type ML/sub2/X/sub2/ and ML/sub4/X/sub2/ (where M=Cu(II),Ni(II), Co(II), Mn(II), Zin(II), Hg(II) and Cd(II); L=6-methyl-2-aminobenzothiazole;X=-I, -NCS and -OAC have been isolated and characterised on the basis of analytical, magnetic moment, molar conductance, electronic and i.r.spectal data. The antifungal screening of Cu(II) and Hg(II) complexes is also reported

Blockchain inspired secure and reliable data exchange architecture for cyber-physical healthcare system 4.0

A cyber-physical system is considered to be a collection of strongly coupled communication systems and devices that poses numerous security trials in various industrial applications including healthcare. The security and privacy of patient data is still a big concern because healthcare data is sensitive and valuable, and it is most targeted over the internet. Moreover, from the industrial perspective, the cyber-physical system plays a crucial role in the exchange of data remotely using sensor nodes in distributed environments. In the healthcare industry, Blockchain technology offers a promising solution to resolve most securities-related issues due to its decentralized, immutability, and transparency properties. In this paper, a blockchain-inspired secure and reliable data exchange architecture is proposed in the cyber-physical healthcare industry 4.0. The proposed system uses the BigchainDB, Tendermint, Inter-Planetary-File-System (IPFS), MongoDB, and AES encryption algorithms to improve Healthcare 4.0. Furthermore, blockchain-enabled secure healthcare architecture for accessing and managing the records between Doctors and Patients is introduced. The development of a blockchain-based Electronic Healthcare Record (EHR) exchange system is purely patient-centric, which means the entire control of data is in the owner's hand which is backed by blockchain for security and privacy. Our experimental results reveal that the proposed architecture is robust to handle more security attacks and can recover the data if 2/3 of nodes are failed. The proposed model is patient-centric, and control of data is in the patient's hand to enhance security and privacy, even system administrators can't access data without user permission

Cost-effectiveness of long-acting reversible contraceptive methods: a review

Long-acting reversible contraception (LARC) methods are proven to be effective in preventing unintended pregnancies. Evidence on cost-effectiveness of these methods will enable policy makers to introduce them in national policies and programs to improve contraceptive access. The aim was to review the studies based on economic evaluations of LARC methods and provide evidence to policy makers to renew their commitment to family planning access. A review of studies on economic evaluations of LARC methods was done. This article uses data from three electronic databases: PubMed, Cochrane and Web of Science to examine whether LARC is cost-effective for clinical trials. The results are presented as a narrative review and summary tables. The literature search yielded 87 studies and 12 studies (five economic evaluations studies from USA) and (five studies from Europe while two studies were from low and middle-income countries) were included. Out of 12 papers, nine had multiple comparators; seven included female sterilization as a comparator, while two studies compared one individual LARC contraceptive method with an individual SARC method. All studies consistently showed that LARCs dominated all SARC (short acting reversible contraceptives) methods. Within LARC, copper IUD, LNG-IUS and implant were more cost-effective than DMPA. After a period of five years, female sterilization turned out to be more cost-effective than LARC methods. LARC methods are cost-effective as compared to SARC methods, especially after 1 year of use. Vasectomy is more cost-effective than LARC methods. Policy makers can consider the findings of this review to aid decision making in contraceptive method introduction or scale-up access

Mixed Ligand Complexes of N-6 methyl Benzothiazol-2-yl-salicylaldimine and 2-methyl Benzimidazole with Cu(II) Ni(II) Co(II) Mn(II) VO(II) Zn(II) Cd(II) and Hg(II)

Mixed-ligand complexes of the type MS/sub2/ (MeBI)/sub2/ (where M=Cu(II), Ni(II), Co(II), Mn(II), Zn(II), Cd(II), Hg(II), SH=N-6-methyl benzothiazol-2-yl-salicyladldimine and MeBI=2-methyl benzimidazole) and VOS/sub2/. MeBI have been synthesised and characterised on the basis of analysis, molar conductance, magnetic moments, electronic and i.r. spectral data. All the complexes, were found to be nonelectrolyte and possessed octahedral geometry

Enhancement of keV X-rays from low-density cellulose triacetate (TAC) foam targets

The interaction of a high-power laser with a low-density foam target can in some instances result in a significant enhancement in x-ray generation relative to that when the same laser is incident upon a homogenous solid. In this paper, we present x-ray emission studies from foam targets where the density is varied from under-dense to over-dense. The targets are irradiated with the first harmonic of Nd:Glass laser. The laser intensity on the target was approximately 2 × 1014 W/cm2 with the pulse duration of 500 ps. Mass-matched cellulose triacetate foam targets with densities of 2 mg/cc, 4 mg/cc, 7 mg/cc, and 20 mg/cc were used. The areal density presented by the targets on the laser beam axis was held constant at 0.2 mg/cm2 by varying the target thickness in inverse proportion to the density. The x-ray yield in the spectral range (5-8 keV) and (4.5-16 keV) was found to be enhanced by approximately 2.3 times in foam targets with the density of 2 mg/cc (under-dense) compared with foam targets with the density of 20 mg/cc (over-dense)

Sirtuin inhibition induces apoptosis-like changes in platelets and thrombocytopenia

Sirtuins are evolutionarily conserved NAD+-dependent acetyl-lysine deacetylases that belong to class III type of histone deacetylases. In humans, seven sirtuin isoforms (Sirt1 to Sirt7) have been identified. Sirtinol, a cell permeable lactone ring derived from naphthol, is a dual Sirt1/Sirt2 inhibitor of low potency whereas EX-527 is a potent and selective Sirt1 inhibitor. Here we have demonstrated that Sirt1, Sirt2 and Sirt3 are expressed in enucleate platelets. Both sirtinol or EX-527 induced apoptosis-like changes in platelets as revealed from enhanced annexin V binding, ROS production and drop in mitochondrial transmembrane potential. Above changes were associated with increased phagocytic clearance of the platelets by macrophages. Expression of acetylated p53 and the conformationally active form of Bax were found to be significantly higher in both sirtinol- as well as EX-527-treated platelets, thus implicating p53-Bax axis in apoptosis induced by sirtuin inhibitors. Administration of either sirtinol or EX-527 in mice led to reduction in both platelet count and number of reticulated platelets. Our results, for the first time, implicate sirtuins as a central player in determination of platelet aging. Since sirtuin inhibitors are being evaluated for their anti-tumor activity, this study rekindles attention to potential side effect of sirtuin inhibition in delimiting platelet life span and management of thrombosis

Multiple brain abscesses of odontogenic origin. May oral microbiota affect their development? a review of the current literature

In the last few years, the role of oral microbiota in the setting of oral diseases such as caries, periodontal disease, oral cancer and systemic infections, including rheumatoid arthritis, car-diovascular disease and brain abscess (BA), has attracted the attention of physicians and researchers. Approximately 5–7% of all BAs have an odontogenic origin, representing an important pathological systemic condition with a high morbidity and mortality. A systematic search of two databases (Pubmed and Ovid EMBASE) was performed for studies published up to 5 January 2021, reporting multiple BAs attributed to an odontogenic origin. According to PRISMA guidelines, we included a total of 16 papers reporting multiple BAs due to odontogenic infections. The aim of this review is to investigate the treatment modality and the clinical outcome of patients with multiple BAs due to odontogenic infections, as well as to identify the most common pathogens involved in this pathological status and their role, in the oral microbiota, in the onset of oral infections. A multidisciplinary approach is essential in the management of multiple BAs. Further studies are required to understand better the role of microbiota in the development of multiple BAs

First occurrence of foot rot of chickpea caused by Operculella padwickii in Bangladesh and Nepal

hile conducting diagnostic surveys in March 1999 to determine the chickpea disease prevalence in the rice-wheat cropping systems of Bangladesh and Nepal, a new disease of chickpea showing symptoms of foot rot (O. padwickii [Phacidiopycnis padwickii]) was observed. Dark brown to black sunken lesions on cotyledons and collar region of the plant were observed. Later, the lesions enlarged, became sunken, dark brown to black, extending to the epicotyl and basal tap root of the plant. In advanced stages of disease development, a complete girdling of the plant in the collar region took place, resulting in the wilting and death of the plants. Leaves were pale green and finally became straw-coloured. In culture, the fungus produced white mycelium and pycnidia. Long and short conidiophores were observed. The pathogen was confirmed as O. padwickii. Pathogenicity tests were conducted and the pathogen was reisolated from the infected plants. This is thought to be the first report of O. padwickii on chickpea in Bangladesh and Nepal

Relative Biological Effectiveness Studies Using 3 MeV Proton Beam from Folded Tandem Ion Accelerator: An Experimental and Theoretical Approach

Proton being the easiest light ion to accelerate and achieve desired beam profile, has been pursued as a popular particulate radiation for therapy applications. In the present study, Saccharomyces cerevisiae D7 strain was used to estimate the RBE values of the 3 MeV proton beam, and an attempt was made to derive mathematical formula for calculating RBE value with respect to the dose. Dosimetry studies were carried out using Fricke dosimetry and Semiconductor Surface Barrier detector to calibrate the absorbed doses of Gamma chamber-1200 and Folded Tandem Ion Accelerator respectively. Gold standard cell survival assay and gene conversion assay were used to compare gamma and proton radiation induced cell death and genetic endpoint. Multi target single hit model was used to derive mathematical formula for RBE estimation. The results show a linear survival-dose response after proton radiation and sigmoid survival-dose response after gamma radiation treatment. The calculated RBE value from the survival and gene conversion studies was 1.60 and 3.93, respectively. The derived mathematical formula is very useful in calculating RBE value, which varies from 3.61 to 1.80 with increasing dose. The estimated RBE value from the mathematical formula is comparable with the experimental values. With the help of the present mathematical formulation, RBE value at any dose can be calculated in the exponential and sigmoidal regions of the survival curve without actually extending the experiment in that dose region, which is not possible using conventional methods