Oprah\u27s Not Over \u27Til Harpo Returns

Peter Newby\u27s theory of \u27Arepoid\u27 word squares being merely classical recreational linguistics is fine as far as it goes, but he marred his discussion by supplying perfect examples of English construction. If, as he suggests, AREPO is a non-word, then each of his squares also should have contained a non-word

You Will Oscar, You Will

The November 1990 Word Ways carried an article entitled The Shaming of the True by one Peter Newby - whoever he may be. His premise, supported by a series of non-anagrams, was to the effect that the film Kiss Me Kate was written by the actor whom he misspelt as James \u27Stuart\u27. This is nonsense

Glycine Betaine Fluxes in Lactobacillus plantarum during Osmostasis and Hyper- and Hypo-osmotic Shock

Bacteria respond to changes in medium osmolarity by varying the concentrations of specific solutes in order to maintain constant turgor. The primary response of Lactobacillus plantarum to an osmotic upshock involves the accumulation of compatible solutes such as glycine betaine, proline, and glutamate. We have studied the osmotic regulation of glycine betaine transport in L. plantarum by measuring the overall and unidirectional rates of glycine betaine uptake and exit at osmostasis, and under conditions of osmotic upshock and downshock. At steady state conditions, a basal flux of glycine betaine (but no net uptake or efflux) is observed that amounts to about 20% of the rate of “activated” uptake (uptake at high osmolarity). No direct exchange of 14C-labeled glycine betaine in the medium for unlabeled glycine betaine in the cytoplasm was observed in glucose metabolizing and resting cells, indicating that a separate glycine betaine efflux system is responsible for the exit of glycine betaine. Upon osmotic upshock, the uptake system for glycine betaine is rapidly activated (within seconds), whereas the basal efflux is inhibited. These two responses account for a rapid accumulation of glycine betaine until osmostasis is reached. Upon osmotic downshock, glycine betaine is rapidly released by the cells in a process that has two kinetic components, i.e. one with a half-life of less than 2 s which is unaffected by the metabolic status of the cells, the other with a half-life of 4–5 min in glucose-metabolizing cells which is dependent on internal pH or a related parameter. We speculate that the former activity corresponds to a stretch-activated channel, whereas the latter may be facilitated by a carrier protein. Glycine betaine uptake is strongly inhibited immediately after an osmotic downshock, but slowly recovers in time. These studies demonstrate that in L. plantarum osmostasis is maintained through positive and negative regulation of both glycine betaine uptake and efflux, of which activation of uptake upon osmotic upshock and activation of a “channel-like” activity upon osmotic downshock are quantitatively most important.

Effects of GRAS substances on pharmacologic effects of drugs

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117153/1/cpt1977225part2743.pd

Movement and Countermovement: Loosely Coupled Conflict

http://deepblue.lib.umich.edu/bitstream/2027.42/51070/1/302.pd

Governance of basic services provision in sub-Saharan Africa and the need to shift gear

During 1970 to mid 1980s, governments’ policies on basic services in sub-Saharan Africa (SSA) had an almost exclusive focus on directly provided, publicly-funded. This approach coupled with disintegration of the economic structures resulted in steep decline in people’s access to basic services. Recent developments however show that policies and strategies have changed and so is people’s access to the services. Decentralisation within the state and from the state to market and to civil society has been implemented in an unprecedented fashion in a number of countries. In addition, the strategy of ‘unbundled’ chain of service production has resulted in increasingly complex institutional arrangements between governments and non-state actors. Using data on the provision of primary education, primary health care, sanitation and solid waste collection, and drinking water from a number of countries in SSA, this paper shows that the new approach has not only changed how basic services are provided and managed but has also influenced improvements in coverage and people’s access, though quality varies and inequalities between localities have not much declined

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure.

Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca2+) handling, energy failure and impaired mitophagy resulting in contractile dysfunction and myocyte death. We have previously shown that the 18-kDa mitochondrial translocator protein of the outer mitochondrial membrane (TSPO) can modulate mitochondrial Ca2+ uptake. Experiments were designed to test the role of the TSPO in a murine pressure-overload model of HF induced by transverse aortic constriction (TAC). Conditional, cardiac-specific TSPO knockout (KO) mice were generated using the Cre-loxP system. TSPO-KO and wild-type (WT) mice underwent TAC for 8 weeks. TAC-induced HF significantly increased TSPO expression in WT mice, associated with a marked reduction in systolic function, mitochondrial Ca2+ uptake, complex I activity and energetics. In contrast, TSPO-KO mice undergoing TAC had preserved ejection fraction, and exhibited fewer clinical signs of HF and fibrosis. Mitochondrial Ca2+ uptake and energetics were restored in TSPO KO mice, associated with decreased ROS, improved complex I activity and preserved mitophagy. Thus, HF increases TSPO expression, while preventing this increase limits the progression of HF, preserves ATP production and decreases oxidative stress, thereby preventing metabolic failure. These findings suggest that pharmacological interventions directed at TSPO may provide novel therapeutics to prevent or treat HF

Kinetic Equations for Longwavelength Excitations of the Quark-Gluon Plasma

We show that longwavelength excitations of the quark-gluon plasma are described by simple kinetic equations which represent the exact equations of motion at leading order in $g$. Properties of the so-called ``hard thermal loops'', i.e. the dominant contributions to amplitudes with soft external lines, find in this approach a natural explanation. In particular, their generating functional appears here as the effective action describing long wavelength excitations of the plasma.Comment: January 8, 1993; 8 pages; SPhT/93-

Humans\u27 Bonding with their Companion Dogs: Cardiovascular Benefits during and after Stress

This study examined whether having one\u27s companion dog present during and after stress posed similar cardiovascular benefits as having a close friend present, even when the relationship quality for both the companion dog and friend was highly positive. Positive aspects of relationship quality for participants\u27 dog and friend were not associated with one another, suggesting that these relationships exist independently. Additionally, compared to participants with a close friend present, those with their dog present had lower heart rate and diastolic blood pressure (p\u27s \u3c .05) while undergoing the stressors, and tended to have lower heart rate and systolic blood pressure (p\u27s \u3c .09) when recovering from stressors. This study indicates that even when relationship quality is similarly high for companion dogs and friends, dogs may be associated with greater reductions in owners\u27 cardiovascular reactivity to stress, particularly if there is a potential for evaluation apprehension in the human friendships. These findings support the value of the human- companion animal relationship in promoting human welfare