Perspective of Saudi undergraduate pharmacy students on pharmacovigilance and adverse drug reaction reporting: A National Survey

Introduction: The purpose of this study was to evaluate Saudi undergraduate pharmacy students’ knowledge, attitude, and readiness towards pharmacovigilance and reporting of adverse drug reactions (ADRs). Methods: A cross-sectional survey was conducted between January 15, 2016 and February 18, 2016 using a structured, validated and pilot-tested questionnaire among senior (year 4, 5, and 6) undergraduate pharmacy students enrolled at a governmental or private university/college. Students completed an online 27-item questionnaire developed using Google Forms™. The questionnaire consisted of four sections: demographics; knowledge about pharmacovigilance and ADR reporting; attitudes towards ADR reporting; and pharmacy students’ readiness towards ADR reporting. Results: Two hundred and fifty-nine students completed the questionnaire. Most of the participants were females (n=174; 67.2%) and were year 4 (n=128; 49.4%) students. Out of a total possible score of seven, the mean knowledge score (SD) was 4.15 (1.1). Multiple linear regression showed that after adjusting for gender and program of study (BPharm/PharmD), year of the study was found to be an independent predictor (p=0.03) of the total knowledge score. More than half of the respondents (n=166; 64.1%) acknowledged that they do not know how to report ADRs to the relevant authorities in Saudi Arabia. The majority (n=213; 82.2%) of respondents believed that information on how to report ADRs should be taught to senior pharmacy students

Optimizing voice over Multi-protocol Label Switching (VoMPLS)

Today, the Voice over Internet Protocol (VoIP) is a very growing service because of the increasing utilization of IP networks in modern enterprises. Its major benefit is the reduction of the operational and infrastructural cost that is vital for disaster management planning. This paper presents a literature review on voice transmission techniques over IP networks and discusses the advantages of the Multi-Protocol Label Switching (MPLS) backbone for transmitting voice packets. This could be a case of an emergent communication case where there is a need for utilizing available infrastructure along with the VoIP protocol. We focus on the identification of the constraints that affects the quality of service provisioning to the end users and we suggest a set of modifications to improve it. Further, we propose a plan to develop a script format to achieve optimization of voice packet (real-time) transmission performance over a MPLS based network

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack the tumour on multiple fronts. Oncolytic or "cancer-killing" viruses (OVs) represent up-and-coming multi-mechanistic immunotherapeutic drugs for the treatment of cancer. In this study, we perform an in-vitro screen based on virus-encoded artificial microRNAs (amiRNAs) and find that a unique amiRNA, herein termed amiR-4, confers a replicative advantage to the VSVΔ51 OV platform. Target validation of amiR-4 reveals ARID1A, a protein involved in chromatin remodelling, as an important player in resistance to OV replication. Virus-directed targeting of ARID1A coupled with small-molecule inhibition of the methyltransferase EZH2 leads to the synthetic lethal killing of both infected and uninfected tumour cells. The bystander killing of uninfected cells is mediated by intercellular transfer of extracellular vesicles carrying amiR-4 cargo. Altogether, our findings establish that OVs can serve as replicating vehicles for amiRNA therapeutics with the potential for combination with small molecule and immune checkpoint inhibitor therapy