174 research outputs found
Looking at the bright side - The story of AA Dor as revealed by its cool companion
Irradiation effects in close binaries are crucial for a reliable
determination of system parameters and understanding the close binary
evolution. We study irradiated light originating from the low mass component of
an eclipsing system comprising a hot subdwarf primary and a low mass companion,
to precisely interpret their high precision photometric and spectroscopic data,
and accurately determine their system and surface parameters. We re-analyse the
archival VLT/UVES spectra of AA Dor system where irradiation features have
already been detected. After removing the predominant contribution of the hot
subdwarf primary, the residual spectra reveal more than 100 emission lines from
the heated side of the secondary with maximum intensity close to the phases
around secondary eclipse. We analyse 22 narrow emission lines of the irradiated
secondary, mainly of OII, with a few CII lines. Their phase profiles constrain
the emission region of the heated side to a radius 95% of the radius of
the secondary. The shape of their velocity profiles reveals two distinct
asymmetry features one at the quadrature and the other at the secondary
eclipse. We identify more than 70 weaker emission lines originating from HeI,
NII, SiIII, CaII and MgII. We correct the radial velocity semi-amplitude of the
center-of-light to the centre-of-mass of the secondary and calculate accurate
masses of both components. The resulting masses =0.46
0.01 and =0.079 0.002 are in perfect
accordance with those of a canonical hot subdwarf primary and a low mass star
just at the substellar limit for the companion. We compute a first generation
atmosphere model of the irradiated low mass secondary, which matches the
observed spectrum well. We find an indication of an extended atmosphere of the
irradiated secondary star.Comment: 13 pages, 9 figures, accepted for publication in A&
ANACAMPTODON SPLACHNOIDES (AMBLYSTEGIACEAE): HUNGARIAN POPULATIONS OF A MOSS SPECIES WITH A PECULIAR HABITAT
Twenty-seven colonies of Anacamptodon splachnoides, a rare and endangered species throughout its distributional range, and protected by law in Hungary, were discovered in the Transdanubian Mountain Range, Balaton Uplands, Vértes and Gerecse Mts, as well as in the North Hungarian Mountains, Börzsöny Mts. Th ey grow in decaying hollows of Quercus cerris fi lled with rain water (dend ro tel ma) or in wet holes without standing water. Th e sites are enumerated, the size of
populations is estimated, and distribution maps, illustrations and a short description of the species are provided
Twinning of cubic diamond explains reported nanodiamond polymorphs
The unusual physical properties and formation conditions attributed to h-, i-, m-, and n-nanodiamond polymorphs has resulted in their receiving much attention in the materials and planetary science literature. Their identification is based on diffraction features that are absent in ordinary cubic (c-) diamond (space group: Fd-3m). We show, using ultra-high-resolution transmission electron microscope (HRTEM) images of natural and synthetic nanodiamonds, that the diffraction features attributed to the reported polymorphs are consistent with c-diamond containing abundant defects. Combinations of {113} reflection and rotation twins produce HRTEM images and d-spacings that match those attributed to h-, i-, and m-diamond. The diagnostic features of n-diamond in TEM images can arise from thickness effects of c-diamonds. Our data and interpretations strongly suggest that the reported nanodiamond polymorphs are in fact twinned c-diamond. We also report a new type of twin ( rotational), which can give rise to grains with dodecagonal symmetry. Our results show that twins are widespread in diamond nanocrystals. A high density of twins could strongly influence their applications
Design of Fault-Tolerant Control for Trajectory Tracking
International audienceThe paper proposes a fault-tolerant integrated control system with the brake and the steering for developing a driver assistance system. The purpose is to design a fault-tolerant control which is able to guarantee the trajectory tracking and lateral stability of the vehicle against actuator fault scenarios. Since both actuators affect the lateral dynamics of the vehicle, in the control design a balance and priority between them must be achieved. The method is extended with a fault-tolerant feature based on a robust LPV method, into which the detected fault information are incorporated. The control design is performed by using the Matlab/Simulink software and the verification of the designed controller is performed by using the CarSim software
The receptor RAGE: Bridging inflammation and cancer
The receptor for advanced glycation end products (RAGE) is a single transmembrane receptor of the immunoglobulin superfamily that is mainly expressed on immune cells, neurons, activated endothelial and vascular smooth muscle cells, bone forming cells, and a variety of cancer cells. RAGE is a multifunctional receptor that binds a broad repertoire of ligands and mediates responses to cell damage and stress conditions. It activates programs responsible for acute and chronic inflammation, and is implicated in a number of pathological diseases, including diabetic complications, stroke, atheriosclerosis, arthritis, and neurodegenerative disorders. The availability of Rage knockout mice has not only advanced our knowledge on signalling pathways within these pathophysiological conditions, but also on the functional importance of the receptor in processes of cancer. Here, we will summarize molecular mechanisms through which RAGE signalling contributes to the establishment of a pro-tumourigenic microenvironment. Moreover, we will review recent findings that provide genetic evidence for an important role of RAGE in bridging inflammation and cancer
REVISION OF THE RED LIST STATUS OF HUNGARIAN BRYOPHYTES 1. NEW OCCURRENCES OF SPECIES PREVIOUSLY THOUGHT TO BE REGIONALLY EXTINCT OR WITHOUT RECENT DATA
For 37 species that have been without recent data and therefore listed in the categories regionally extinct (RE) and data defi cient (DD, DD-va), new occurrences have been detected.
Th ese are documented with precise localities, date of collection, collectors, herbarium specimens, associated bryophytes, and taxonomic annotations where appropriate. Some are also illustrated by photographs, and for three of them we include distribution maps. According to the present state of
knowledge and IUCN criteria, of these 37 species 10 are critically endangered, 14 are endangered, 2 are vulnerable and 5 are near threatened. In spite of the new occurrences, 6 species are rated data defi cient (DD)
Remarkable finds of bryophytes in Hungary during the last two years (2015-2017)
Extant occurrences of 9 species without recent data (DD, DD-va in the Hungarian
bryophyte redlist of 2010) were discovered in the period 2015-2017: Brachythecium
campestre (Börzsöny: 8180.1, Mecsek: 9875.2, VendvidĂ©k: 9163.2, TiszĂĄntĂșl: 8496.2),
B. plumosum (Zempléni-hg.: 7594.1, Måtra: 8186.1, Vértes: 8476.3), Bryum
archangelicum (Börzsöny: 8179.1), Ephemerum serratum (=E. stoloniferum (Hedw.) L.T.
Ellis & M.J. Price) (Börzsöny: 8080.3, ĆrsĂ©g: 9164.3), Jungermannia subulata (Mecsek:
9776.4), Marsupella emarginata (Börzsöny: 8079.2), Orthotrichum rogeri (Zemplénihg.:
7894.3), Pseudoleskea saviana (Måtra: 8186.1, Börzsöny: 8079.2, 8079.4),
Schistidium confertum (Börzsöny: 8079.2, Måtra: 8186.1).
22 taxa were first recorded in Hungary since november 2015: Barbilophozia hatcheri
(Budai-hg.: 8579.2), Brachythecium curtum (Zempléni-hg.: 7594.1, Börzsöny: 8079.4),
Bryum tenuisetum (Csepel-sziget: 8679.2, BelsĆ Somogy: 9971.1, KemeneshĂĄt: 8768.1,
KĆszegi-hg.: 8665.2), Campylopus subulatus (KemeneshĂĄt: 8967.1), Crossidium
squamiferum (Börzsöny: 8279.2), Didymodon tophaceus subsp. erosus (Duna-Tiszaköze:
9786.1), D. tophaceus subsp. sicculus (Duna-Tisza-közé: 9786.1, 9280.4, 8781.1),
Ditrichum lineare (Zempléni-hg.: 7494.4), Fissidens bambergeri (Zempléni-hg.: 7494.2,
BĂŒkk: 8088.1, Börzsöny: 7979.4, 8179.1, 8180.1, VisegrĂĄdi-hg.: 8279.2, 8280.3, Budaihg.:
8479.1, 8479.4, Gerecse: 8377.1, VĂ©rtes: 8675.2, KĆszegi-hg.: 8664.4, 8665.1,
Vendvidék: 9162.2, Zala: 9166.4), F. crispus (Börzsöny: 8079.2), Fossombronia incurva
(VisegrĂĄdi-hg.: 8279.3, ĆrsĂ©g: 9164.3, Geresdi-dombsĂĄg: 9777.3), Heterocladium
heteropterum (KĆszegi-hg.: 8664.2), Pellia neesiana (VendvidĂ©k: 9062.4, 9162.2),
Plagiothecium latebricola (KĆszegi-hg.: 8664.2), Rhabdoweisia crispata (KĆszegi-hg.:
8664.2), Riccia beyrichiana (VisegrĂĄdi-hg.: 8279.2), Seligeria acutifolia (Pilis: 8279.4),
Sematophyllum adnatum (KemeneshĂĄt: 8967.1), Syntrichia ruralis var. epilosa
(Keszthelyi-hg.: 9270.1, KĆszegi-hg.: 8665.1), Ulota crispula (ZemplĂ©ni-hg.: 7594.1,
MĂĄtra: 8085.3, Börzsöny: 8080.1, BalatonfelvidĂ©k: 9171.1, KĆszegi-hg.: 8664.2, 8664.4,
8665.1, 8565.3, VendvidĂ©k: 9062.4, 9163.1, ĆrsĂ©g: 9263.2, KemeneshĂĄt: 8967.1, Zselic:
9873.2), U. intermedia (ZemplĂ©ni-hg.: 7594.3, Börzsöny: 8079.2, KĆszegi-hg.: 8664.2,
Vas-hegycsoport: 8764.4, VendvidĂ©k: 9062.4, ĆrsĂ©g: 9164.3, 9264.1, Zselic: 9873.2),
and Zygodon forsteri (Balatonfelvidék: 9071.3, 9171.1)
Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation
<p>Abstract</p> <p>Background</p> <p>In the past, molecular mechanisms that drive the initiation of an inflammatory response have been studied intensively. However, corresponding mechanisms that sustain the expression of inflammatory response genes and hence contribute to the establishment of chronic disorders remain poorly understood. Recently, we provided genetic evidence that signaling via the receptor for advanced glycation end products (Rage) drives the strength and maintenance of an inflammatory reaction. In order to decipher the mode of Rage function on gene transcription levels during inflammation, we applied global gene expression profiling on time-resolved samples of mouse back skin, which had been treated with the phorbol ester TPA, a potent inducer of skin inflammation.</p> <p>Results</p> <p>Ranking of TPA-regulated genes according to their time average mean and peak expression and superimposition of data sets from wild-type (<it>wt</it>) and <it>Rage</it>-deficient mice revealed that Rage signaling is not essential for initial changes in TPA-induced transcription, but absolutely required for sustained alterations in transcript levels. Next, we used a data set of differentially expressed genes between TPA-treated <it>wt </it>and <it>Rage</it>-deficient skin and performed computational analysis of their proximal promoter regions. We found a highly significant enrichment for several transcription factor binding sites (TFBS) leading to the prediction that corresponding transcription factors, such as Sp1, Tcfap2, E2f, Myc and Egr, are regulated by Rage signaling. Accordingly, we could confirm aberrant expression and regulation of members of the E2f protein family in epidermal keratinocytes of Rage-deficient mice.</p> <p>Conclusions</p> <p>In summary, our data support the model that engagement of Rage converts a transient cellular stimulation into sustained cellular dysfunction and highlight a novel role of the Rb-E2f pathway in Rage-dependent inflammation during pathological conditions.</p
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