Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources

Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a ?One Health? perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identifed in the four candidate genes: 26% of them were not previously described; 29 variants afected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a frst step towards a ?One Health? perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the describedFE1B-06B2-126F | Jos? Pedro Pinto de Ara?joN/

Challenges facing novice principals: A study in Colombian schools using a socialisation perspective

18 p�ginasThis research examined challenges faced by novice principals in Colombia in connecting_x000D_ to their school communities through their socialisation processes. Interviews with 37_x000D_ newly appointed principals in rural and urban schools revealed that the complexity of_x000D_ their school contexts accentuated the need to work on the relational dimension of their_x000D_ jobs. Forging relationships with teachers and parents based on trust and communication,_x000D_ introspection and knowledge about their school communities emerged as crucial factors_x000D_ to foster social justice and to transcend deficit views of their communities. The article_x000D_ questions the role of supporting services for novice principals, emphasises the_x000D_ importance of organisational socialisation, and stresses the role of preparation programs_x000D_ in providing principals with tools for learning during this phase of their professional_x000D_ careers

Evaluaci?n y manejo cl?nico de las autolesiones en la adolescencia: protocolo basado en la evidencia

Las autolesiones se han convertido en un importante problema de salud p?blica en la adolescencia. El t?rmino autolesi?n o lesi?n autoinfligida, se ha definido como un acto llevado a cabo por una persona con el objetivo de hacerse da?o a s? mismo. Independientemente de las consecuencias que la autolesi?n pueda tener para la salud f?sica o mental, puede asociarse a distintos niveles de intencionalidad suicida. En el caso de que esta no existiera se denomina autolesi?n no suicida. El incremento de las autolesiones en la adolescencia ha sido progresivo en las ?ltimas d?cadas, con un incremento exponencial en los 10 ?ltimos a?os. Adem?s, en la actualidad se ha detectado un incremento notorio de las autolesiones en la poblaci?n adolescente, en parte, relacionado con el estr?s psicol?gico y distanciamiento social causado por la pandemia por COVID-19. El objetivo general de este documento es elaborar un documento basado en la evidencia cient?fica que permita favorecer una mejor evaluaci?n y manejo cl?nico de las autolesiones en la adolescencia. En la actualidad, las autolesiones constituyen un grave problema en la poblaci?n adolescente y, por ello, es relevante establecer los mecanismos que permitan su adecuada detecci?n y manejo cl?nico. El presente documento sintetiza la evidencia m?s relevante, as? como recoge las principales actuaciones en atenci?n primaria y atenci?n especializada, con el objetivo de guiar a los profesionales y favorecer la toma de decisiones compartida. Tambi?n se proponen indicadores para la monitorizaci?n de la pr?ctica cl?nica y se ha desarrollado un documento para adolescentes, familias y profesionales de la educaci?n. La investigaci?n futura deber? centrarse en evaluar la efectividad de las diferentes intervenciones y dise?ar nuevos enfoques preventivos y terap?uticos