Diversity of ornamental trees from Amravati city of West Vidarbha region

The present study deals with the diversity of ornamental trees from Amravati District of West Vidarbha region of Maharashtra. All these ornamental trees show diversity in their habitat, floral structure, flowering period, etc. In the present investigation, extensive field surveys were conducted in the different localities of Amravati district during 2005-2011containing description, distribution, origin, vegetative and flowering period of 25 ornamental trees species from 19 families with their photographs and preserved as Herbaria

Phytochemical screening of some Euphorbiaceae members

The present investigation includes the Phytochemical screening of some medicinally important plants from the family Euphorbiaceae. All the members studied are exotic but naturalized except Ricinnus communis L. which is commercially cultivated in India. Plant extracts were prepared in various solvents and phytochemically they were tested in the solvent where the good extraction or active extraction observed, Phytochemical tests were carried out specially for screening secondary metabolites from the selected exotic medicinal plants from family Euphorbiaceae. Six genera and seven species of Euphorbiaceae were phytochemically analyzed to find secondary metabolites. Â

Treatment strategies in primary vitreoretinal lymphoma: a 17-center European collaborative study.

IMPORTANCE: The best treatment option for primary vitreoretinal lymphoma (PVRL) without signs of central nervous system lymphoma (CNSL) involvement determined on magnetic resonance imaging or in cerebrospinal fluid is unknown. OBJECTIVE: To evaluate the outcomes of treatment regimens used for PVRL in the prevention of subsequent CNSL. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study was conducted at 17 referral ophthalmologic centers in Europe. We reviewed clinical, laboratory, and imaging data on 78 patients with PVRL who did not have CNSL on presentation between January 1, 1991, and December 31, 2012, with a focus on the incidence of CNS manifestations during the follow-up period. INTERVENTIONS: The term extensive treatment was used for various combinations of systemic and intrathecal chemotherapy, whole-brain radiotherapy, and peripheral blood stem cell transplantation. Therapy to prevent CNSL included ocular radiotherapy and/or ocular chemotherapy (group A, 31 patients), extensive systemic treatment (group B, 21 patients), and a combination of ocular and extensive treatment (group C, 23 patients); 3 patients did not receive treatment. A total of 40 patients received systemic chemotherapy. MAIN OUTCOMES AND MEASURES: Development of CNSL following the diagnosis of PVRL relative to the use or nonuse of systemic chemotherapy and other treatment regimens. RESULTS: Overall, CNSL developed in 28 of 78 patients (36%) at a median follow-up of 49 months. Specifically, CNSL developed in 10 of 31 (32%) in group A, 9 of 21 (43%) in group B, and 9 of 23 (39%) in group C. The 5-year cumulative survival rate was lower in patients with CNSL (35% [95% CI, 50% to 86%]) than in patients without CNSL (68% [95% CI, 19% to 51%]; P = .003) and was similar among all treatment groups (P = .10). Adverse systemic effects occurred in 9 of 40 (23%) patients receiving systemic chemotherapy; the most common of these effects was acute renal failure. CONCLUSIONS AND RELEVANCE: In the present series of patients with isolated PVRL, the use of systemic chemotherapy was not proven to prevent CNSL and was associated with more severe adverse effects compared with local treatment

High-Sensitivity Cardiac Troponin I and the Diagnosis of Coronary Artery Disease in Patients with Suspected Angina Pectoris

Background: High-sensitivity assays can quantify cardiac troponin I concentrations in nearly all individuals. We determined whether cardiac troponin can improve our estimation of the pre-test probability for obstructive coronary artery disease in patients with suspected stable angina. Methods: In a pre-specified sub-study of the Scottish COmputed Tomography of the Heart (SCOT-HEART) trial, plasma cardiac troponin I was measured using a high-sensitivity single molecule counting assay (Singulex) in 943 adults with suspected stable angina who had undergone coronary computed tomography angiography. Rates of obstructive coronary artery disease (diameter stenosis ≥50% in ≥1 major epicardial vessel) were compared with the pre-test probability determined by the European Society of Cardiology (ESC) Coronary Artery Disease Consortium risk model with and without cardiac troponin concentrations. Results: Higher cardiac troponin concentrations were associated with obstructive coronary artery disease with a 5-fold increase across quintiles (9 to 48%, p < 0.001) independent of known cardiovascular risk factors (odds ratio [OR] 1.35 [95% confidence interval (CI) 1.25-1.46] per doubling of troponin). Cardiac troponin concentrations improved the discrimination of the ESC model for identifying obstructive coronary artery disease (c-statistic 0.785 to 0.800, p < 0.003) and improved classification into ESC-recommended categories of clinical risk (net reclassification improvement 0.143 [95% CI, 0.093-0.193]). Conclusions: High-sensitivity cardiac troponin I concentration is an independent predictor of obstructive coronary artery disease in patients with suspected stable angina. Use of this test may improve the selection of patients for further investigation and treatment