Epitaxially strained ultrathin LaNiO3_3/LaAlO3_3 and LaNiO3_3/SrTiO3_3 superlattices: a density functional theory + UU study

By employing first-principles electronic structure calculations we investigate nickelate superlattices [LaNiO$_3$]$_1$/[LaAlO$_3$]$_1$ and [LaNiO$_3$]$_1$/[SrTiO$_3$]$_1$ with (001) orientation under epitaxial tensile strain. Within density functional theory augmented by mean-field treatement of on-site electronic correlations, the ground states show remarkable dependence on the correlation strength and the strain. In the weakly and intermediately correlated regimes with small epitaxial strain, the charge-disproportionated insulating states with antiferromagneitc order is favored over the other orbital and spin ordered phases. On the other hand, in the strongly correlated regime or under the large tensile strain, ferromagnetic spin states with Jahn-Teller orbital order become most stable. The effect from polar interfaces in LaNiO$_3$]$_1$/[SrTiO$_3$]$_1$ is found to be noticeable in our single-layered geometry. Detailed discussion is presented in comparison with previous experimental and theoretical studies.Comment: 9 pages, 8 figure

Chaotic universe in the z=2 Hovava-Lifshitz gravity

The deformed z=2 Horava-Lifshitz gravity with coupling constant w leads to a nonrelativistic "mixmaster" cosmological model. The potential of theory is given by the sum of IR and UV potentials in the ADM Hamiltonian formalism. It turns out that adding the UV-potential cannot suppress chaotic behaviors existing in the IR-potential.Comment: 7 pages, 5 figures, version to appear in PR

Epidemiology and Investigation of Foot‐and‐Mouth Disease (FMD) in the Republic of Korea

This chapter describes about the experience of dealing with FMD outbreaks in the Republic of Korea. We explain what is FMD, the concept of epidemiological investigation on outbreak sites of FMD, including the episode of detecting the index case for seven epidemics occurred since 2000, and information obtained from investigation in Korea. In any case, farmers’ attitude (recognize clinical signs and report suspected cases) played the essential role in determining size and duration of epidemics. A rapid and correct diagnosis including clinical examination and laboratory test for confirmation is also important

Pengaruh Tingkat Inflasi, Tingkat Suku Bunga SBI, Nilai Tukar Rupiah, Indeks Dow Jones, Dan Indeks Klse Terhadap Indeks Harga Saham Gabungan (Ihsg) Studi Pada Bursa Efek Indonesia Periode Januari 2010 – Desember 2013

This research aimed to know the effect of inflation rate, SBI rate, Rupiah exchange rate, Dow Jones index, KLSE index towards Composite Stock Price Index (CSPI). Types of research used in explanatory research with quantitative approach. The sample was based on monthly time series data from January 2010 - December 2013, used full sampling method which consist of 48 samples. This research used multiple linear regression method. The value coefficient of determination (R2) 0,84, means the independent variables inflation rate, SBI rate, Rupiah exchange rate, Dow Jones index, KLSE index, explain the dependent variable Composite Stock Price Index (CSPI) up to 84% and the remaining 16% explained by the other that had not been examined. Simultaneous test result (F test), indicating that inflation rate, SBI rate, Rupiah exchange rate, Dow Jones index, KLSE index has significant effect on the Composite Stock Price Index (CSPI) simultaneously. Partial test result (t test), indicates that inflation rate showed a insignificant influence on CSPI, while SBI rate and Rupiah exchange rate had a negative effect and significant to CSPI, Dow Jones index and KLSE index had a positive and significant to CSPI. The most dominant influential variable in this research is Dow Jones Index

Aberrant phenotypes of transgenic mice expressing dimeric human erythropoietin

<p>Abstract</p> <p>Background</p> <p>Dimeric human erythropoietin (dHuEPO) peptides are reported to exhibit significantly higher biological activity than the monomeric form of recombinant EPO. The objective of this study was to produce transgenic (tg) mice expressing dHuEPO and to investigate the characteristics of these mice.</p> <p>Methods</p> <p>A dHuEPO-expressing vector under the control of the goat beta-casein promoter, which produced a dimer of human EPO molecules linked by a 2-amino acid peptide linker (Asp-Ile), was constructed and injected into 1-cell fertilized embryos by microinjection. Mice were screened using genomic DNA samples obtained from tail biopsies. Blood samples were obtained by heart puncture using heparinized tubes, and hematologic parameters were assessed. Using the microarray analysis tool, we analyzed differences in gene expression in the spleens of tg and control mice.</p> <p>Results</p> <p>A high rate of spontaneous abortion or death of the offspring was observed in the recipients of dHuEPO embryos. We obtained 3 founder lines (#4, #11, and #47) of tg mice expressing the <it>dHuEPO </it>gene. However, only one founder line showed stable germline integration and transmission, subsequently establishing the only transgenic line (#11). We obtained 2 F1 mice and 3 F2 mice from line #11. The dHuEPO protein could not be obtained because of repeated spontaneous abortions in the tg mice. Tg mice exhibited symptoms such as short lifespan and abnormal blood composition. The red blood cell count, white blood cell count, and hematocrit levels in the tg mice were remarkably higher than those in the control mice. The spleens of the tg mice (F1 and F2 females) were 11- and -21-fold larger than those of the control mice. Microarray analysis revealed 2,672 spleen-derived candidate genes; more genes were downregulated than upregulated (849/764). Reverse transcriptase-polymerase chain reaction (RT-PCR) and quantitative real-time PCR (qRT-PCR) were used for validating the results of the microarray analysis of mRNA expression.</p> <p>Conclusions</p> <p>In conclusion, dHuEPO tg mice caused excessive erythrocytosis that led to abnormal blood composition, short lifespan, and abnormal splenomegaly. Further, we identified 2,672 genes associated with splenomegaly by microarray analysis. These results could be useful in the development of dHuEPO-producing tg animals.</p