The mythical countertextual : from Derrida to Badiou

The modern era stages a confrontation between humanity and its finitude. God is dead. The thing in itself, the world as it is in itself, us as we are in ourselves, are all recognised as being ultimately beyond our cognitive grasp. The realisation that the act of thinking cannot be fully taken into consideration in the thought that is produced by that act, forces the yawning of the chasm out of which a veritable plague of dualisms emerge. No matter how hard or deeply we think, a part of who or what we are – perhaps the constitutive part – remains irrevocably in the shadows. Without being able to take account of this in a way that might allow us to subtract it from what already counts as knowledge, to reveal the pure datum unsullied, as it were, by human hands, such knowledge – which might previously have been considered absolute – is revealed as irredeemably relational. To say what something is, is always, on some level, to say what it is for us. What this means is that even that of which we are most sure must, in the last analysis, be considered subjective. It is in this regard that Badiou speaks of ‘disobjectivation’ and of ‘the destitution of the category of object’, characteristics of what he refers to as ‘the age of poets’ [manifesto for philosophy, 72].)peer-reviewe

Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?

Introduction: Many of the DNA sequence variants identified in the breast cancer susceptibility gene BRCA1 remain unclassified in terms of their potential pathogenicity. Both multifactorial likelihood analysis and functional approaches have been proposed as a means to elucidate likely clinical significance of such variants, but analysis of the comparative value of these methods for classifying all sequence variants has been limited. Methods: We have compared the results from multifactorial likelihood analysis with those from several functional analyses for the four BRCA1 sequence variants A1708E, G1738R, R1699Q, and A1708V. Results: Our results show that multifactorial likelihood analysis, which incorporates sequence conservation, co-inheritance, segregation, and tumour immunohistochemical analysis, may improve classification of variants. For A1708E, previously shown to be functionally compromised, analysis of oestrogen receptor, cytokeratin 5/6, and cytokeratin 14 tumour expression data significantly strengthened the prediction of pathogenicity, giving a posterior probability of pathogenicity of 99%. For G1738R, shown to be functionally defective in this study, immunohistochemistry analysis confirmed previous findings of inconsistent 'BRCA1-like' phenotypes for the two tumours studied, and the posterior probability for this variant was 96%. The posterior probabilities of R1699Q and A1708V were 54% and 69%, respectively, only moderately suggestive of increased risk. Interestingly, results from functional analyses suggest that both of these variants have only partial functional activity. R1699Q was defective in foci formation in response to DNA damage and displayed intermediate transcriptional transactivation activity but showed no evidence for centrosome amplification. In contrast, A1708V displayed an intermediate transcriptional transactivation activity and a normal foci formation response in response to DNA damage but induced centrosome amplification. Conclusion: These data highlight the need for a range of functional studies to be performed in order to identify variants with partially compromised function. The results also raise the possibility that A1708V and R1699Q may be associated with a low or moderate risk of cancer. While data pooling strategies may provide more information for multifactorial analysis to improve the interpretation of the clinical significance of these variants, it is likely that the development of current multifactorial likelihood approaches and the consideration of alternative statistical approaches will be needed to determine whether these individually rare variants do confer a low or moderate risk of breast cancer

Structural changes in economics of Bangladesh during the period 1971-2021

In my thesis, I attempted to highlight the economic growth that has taken place in Bangladesh during the time period 1971-2021.BSc/BABsc in Business Administration and Managemen